34 completed, 16 unknown, 6 terminated, 3 withdrawn. 30 Phase 4, 10 Phase 3, 9 Phase 2, 5 Not applicable, 5 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) Finerenone, Semaglutide, Lotensin - Chronic Kidney Disease, Type 2 Diabetes | Phase 4 | Enrolling by invitation | Baylor Research Institute | 64 | 2026-04-08 | 2026-10-13 |
| Evaluation of the Antihypertensive effectIveness, Tolerability, and Adherence With Amlodipine/ Indapamide/ Perindopril Triple Single-pill Combination in Hypertensive Patients Without Concomitant Antihypertensive Therapy (TRIPTYCH) Amlodipine 5 mg + indapamide 1.25 mg + perindopril 5 mg, Amlodipine 5 mg + indapamide 2.5 mg + perindopril 10 mg, Amlodipine 10 mg + indapamide 2.5 mg + perindopril 10 mg - Arterial Hypertension, HTN | Completed | Servier Russia | 396 | 2024-05-01 | 2025-06-11 | |
| Timely Recovery After Subclinical Heart Failure Perindopril - Heart Failure, Diastolic Dysfunction | Phase 4 | Unknown | Academisch Ziekenhuis Maastricht | 130 | 2024-03-26 | 2024-04-02 |
| Bioequivalence Study of Perindopril Tablets in Healthy Volunteers Under Fasting Conditions Perindopril tablet, Prestarium® A tablet - Bioequivalence | Phase 1 | Unknown | Pharmtechnology LLC | 50 | 2024-01-09 | 2024-01-19 |
| Bioequivalence Study of Perindopril /Amlodipine/Indapamide 8 mg (10 mg)/2.5 mg/10 mg Tablets in Healthy Volunteers Under Fasting Conditions Perindopril/Indapamide/Amlodipine 8 mg/2.5 mg/10 mg tablet / Triplixam® 10 mg/2.5 mg/10 mg tablet - Bioequivalence | Phase 1 | Unknown | Pharmtechnology LLC | 50 | 2023-06-24 | 2023-07-11 |
| Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia Atorvastatin/Perindopril, Atorvastatin, Perindopril - Dyslipidemias, Hypertension | Phase 3 | Terminated | Institut de Recherches Internationales Servier | 146 | 2021-09-09 | 2023-10-18 |
| Early Treatment of ARNI on Myocardial Remodeling and Progress sacubitril/valsartan, perindopril, Cardiopulmonary Exercise Test - Myocardial Infarction | Phase 4 | Unknown | RenJi Hospital | 280 | 2020-05-01 | 2020-04-14 |
| Coronavirus (COVID-19) ACEi/ARB Investigation Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor - Hypertension, COVID-19 | Phase 4 | Suspended | National University of Ireland, Galway, Ireland | 2414 | 2020-04-30 | 2020-06-30 |
| Effect of Atorvastatin on Carotid Intima Media Thickness Perindopril/Amlodipine and Perindopril/Amlodipine/Atorvastatin treatment - Essential Hypertension, Hypercholesterolemia | Phase 4 | Unknown | Yerevan State Medical University | 200 | 2020-04-15 | 2020-03-13 |
| ACEI or ARB and COVID-19 Severity and Mortality in US Veterans ACEI/ARB, Non-ACEI/ARB, ACEI - Hypertension, COVID | Completed | University of Utah | 22213 | 2020-01-19 | 2021-04-28 | |
| Precision Treatment With Angiotensin Converting Enzyme Inhibitor genotyping and selection of renin-angiotensin system blocker, Perindopril - Hypertension | Phase 4 | Completed | Yonsei University | 77 | 2019-11-06 | 2023-01-11 |
| One Versus Twice Daily Administration of Multiple Cardiovascular Agents in Patients With Ischemic Heart Disease Aspirin, Atorvastatin, Perindopril - Ischemic Heart Disease | Phase 4 | Unknown | University of Roma La Sapienza | 100 | 2019-11-01 | 2019-11-05 |
| Prevention of Cardiovascular Diseases Caused by Complex Treatment of Patients With Primary Operated Breast Cancer Bisoprolol; Perindopril; - Women With Breast Cancer | Phase 2 | Completed | State Institution "Republican Scientific and Practical Center" Cardiology, Belarus | 100 | 2019-07-01 | 2023-02-08 |
| Moxonidine + Perindopril in Hypertensive Patients With Metabolic Syndrome perindopril + moxonidine - Arterial Hypertension, Metabolic Syndrome | Phase 4 | Unknown | Sergey V. Nedogoda | 120 | 2019-03-11 | 2019-07-23 |
| Safety and Efficacy of Two Year of RAAS Alone or in Combination With Spironolactone Therapy Renin-Angiotensin (RAAS) alone, Renin-Angiotensin (RAAS) blockers in combination with Spironolactone - Renal Insufficiency, Chronic, Diabetic Nephropathy Type 2 | Phase 4 | Unknown | James A. Tumlin, MD | 72 | 2018-10-01 | 2022-10-28 |
| Comparative Effects of Perindopril and Zofenopril on Blood Pressure Control and Oxidative Status Blacks Hypertensive Patients. Perindopril Arginine, Zofenopril, Calcium Salt, (1(R*),2Alpha,4Alpha)-isomer - Hypertension | Phase 4 | Completed | Yaounde Central Hospital | 24 | 2018-10-01 | 2020-02-05 |
| ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension Aerobic exercise, Perindopril, Losartan - Hypertension, Aging | Phase 2 | Completed | University of Alabama at Birmingham | 223 | 2018-05-29 | 2025-07-22 |
| Evaluation of the Clinical Efficacy and Safety of Amlodipine 5mg/ Bisoprolol Fumarate 5mg /Perindopril Arginine 5mg Fixed-dose Combination in Capsule and Free Monotherapy at the Same Dose in Patients With Uncontrolled Essential Hypertension. Amlodipine 5mg + bisoprolol fumarate 5mg + perindopril arginine 5mg, Norvasc 5mg tablet, Concor 5mg tablet - Essential Hypertension | Phase 3 | Completed | Servier | 150 | 2018-05-14 | 2025-06-05 |
| Evaluation of Losartan and Perindopril in Blacks Type 2 Diabetics Patients Perindopril Arginine, Losartan Potassium - Type 2 Diabetes Mellitus | Phase 4 | Completed | Yaounde Central Hospital | 23 | 2017-12-20 | 2020-01-10 |
| Fixed Combination for Lipid and Blood Pressure Control Atorvastatin, Amlodipine, Perindopril - Arterial Hypertension, Dyslipidemias | Phase 4 | Withdrawn | Charles University, Czech Republic | 2017-09-01 | 2019-06-21 |
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Hypertension (26) · Essential Hypertension (7) · Diabetes Mellitus, Type 2 (4) · Heart Failure (4) · Renal Insufficiency, Chronic (4) · Atrial Fibrillation (2) · COVID-19 (2) · Diabetes Mellitus (2) · Dyslipidemias (2) · Marfan Syndrome (2) · Albuminuria (1) · Alzheimer Disease (1) · Breast Neoplasms (1) · Cardiomyopathy, Dilated (1) · Cardiotoxicity (1)
Institut de Recherches Internationales Servier (3) · University of Roma La Sapienza (3) · Yaounde Central Hospital (3) · Baylor College of Medicine (2) · Pharmtechnology LLC (2) · Roxane Laboratories (2) · Sunnybrook Health Sciences Centre (2) · Academisch Ziekenhuis Maastricht (1) · Anna Posadzy-Małaczyńska (1) · Baylor Research Institute (1) · Bayside Health (1) · Boryung Pharmaceutical Co., Ltd (1) · British Columbia Cancer Agency (1) · Cardiff University (1) · Charles University, Czech Republic (1)
United States (12) · Canada (7) · Russia (7) · France (6) · Italy (6) · United Kingdom (6) · China (5) · Netherlands (4) · Spain (4) · Australia (2) · Cameroon (2) · Czechia (2) · Finland (2) · Germany (2) · Ireland (2)
Alexandra Konradi (2) · Carlo Gaudio, MD (2) · Patrick Niaudet, Pr (2) · Adam P Bress, PharmD, MS (1) · Bernard Geny, MD (1) · Bongani Mayosi, DPhil (1) · Bret Goodpaster, PhD (1) · Bronwyn A Kingwell, PhD (1) · Christopher J Bulpitt, MD, FRCP (1) · Colin McArthur, Dr (1) · Danang A Yunaidi, MD (1) · Daniel J Renouf, MD (1) · Derek Angus, Prof (1) · Derek T Connelly, MBChB (1)
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