3 completed, 3 terminated, 2 recruiting, 2 unknown. 9 Not applicable, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Terminated 3, Completed 2, Unknown 2, Recruiting 1, Withdrawn 1 |
| Phase 2 | 1 | Recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Non-Invasive Positive Pressure Ventilation: new trials by email Literature Review of Non-Invasive Positive Pressure Ventilation trials Research Report on Non-Invasive Positive Pressure Ventilation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen - Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS) | Not applicable | Recruiting | Ohio State University | 500 | 2026-08-18 | 2026-10-01 |
| A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS) Non-invasive ventilation - Amyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure | Phase 2 | Recruiting | University of Pennsylvania | 48 | 2026-06-11 | 2026-06-26 |
| HVNI for Successful Weaning in Respiratory Failure High Velocity Nasal Insufflation, Non-invasive positive pressure ventilation - Respiratory Failure, Weaning Failure | Not applicable | Unknown | Alexandria University | 40 | 2023-04-01 | 2023-05-11 |
| NIV-MISA-NRDS Trial: a Multicenter Study in China Nasal continuous positive airway pressure, Non-invasive positive pressure ventilation - Minimal Invasive Surfactant Administration in Two Different Non-invasive Ventilation Modes to NRDS Infants | Not applicable | Terminated | Peking University Third Hospital | 312 | 2021-12-01 | 2025-07-09 |
| RENOVATE Fibrosis:HFNC Versus NIPPV in Acute Respiratory Failure in Patients With Pulmonary Fibrosis High Flow Nasal Catheter, Noninvasive positive pressure ventilation (NIPPV) - Acute Respiratory Failure, Pulmonary Fibrosis | Not applicable | Terminated | Hospital do Coracao | 3 | 2020-12-10 | 2021-08-16 |
| RENOVATE Palliative: HFNC vs. Standard Respiratory Support in Patients With Do-Not-Intubate Order and ARF High Flow Nasal Cannula, Standard respiratory support - Care, Palliative, Respiratory Failure | Not applicable | Terminated | Hospital do Coracao | 3 | 2020-12-01 | 2021-08-16 |
| Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema Non-Invasive Positive Pressure Ventilation, Nifedipine, supplemental oxygen - High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation | Not applicable | Unknown | Massachusetts General Hospital | 16 | 2020-03-01 | 2020-09-03 |
| Mask Leak With Nasal Cannula in Noninvasive Positive Pressure Ventilation Nasal cannula, Non-invasive positive pressure ventilation - Mechanical Ventilation Pressure High | Phase 4 | Completed | Brooke Army Medical Center | 64 | 2016-04-01 | 2016-09-26 |
| Impact of Non-invasive Positive Pressure Ventilation on Cardiac Function and Echocardiographic Parameters Non-invasive positive pressure ventilation - Heart Function Tests, Hemodynamics | Not applicable | Completed | Insel Gruppe AG, University Hospital Bern | 30 | 2015-06-01 | 2018-10-30 |
| High Flow Therapy (HFT) to Treat Respiratory Insufficiency in Chronic Obstructive Pulmonary Disease (COPD) Vapotherm High Flow Therapy, Non-invasive positive pressure ventilation - Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency | Not applicable | Withdrawn | Vapotherm, Inc. | 2009-09-01 | 2020-09-16 | |
| Trial of Non-invasive Ventilation for Stable COPD Bipap (Respironics, Inc) - COPD | Not applicable | Completed | University of Iowa | 40 | 2001-04-01 | 2012-11-07 |
Respiratory Insufficiency (5) · Pulmonary Disease, Chronic Obstructive (3) · Altitude Sickness (1) · Amyotrophic Lateral Sclerosis (1) · Hypoxia (1) · Neuromuscular Diseases (1) · Pulmonary Fibrosis (1) · Respiratory Distress Syndrome (1)
Hospital do Coracao (2) · Alexandria University (1) · Brooke Army Medical Center (1) · Insel Gruppe AG, University Hospital Bern (1) · Massachusetts General Hospital (1) · Ohio State University (1) · Peking University Third Hospital (1) · University of Iowa (1) · University of Pennsylvania (1) · Vapotherm, Inc. (1)
United States (5) · Brazil (2) · China (1) · Egypt (1) · Nepal (1) · Switzerland (1)
Leticia Kawano-Dourado, MD (2) · Alexandre B Cavalcanti, MD (1) · Fernando Zampieri, MD (1) · Henry E Wang, MD, MS (1) · Israel Maia, MD (1) · Israel S Maia, MD (1) · Jarrod Mosier, MD (1) · Jason T Ackrivo, MD, MSCE (1) · Lai Wei, PhD (1) · Lara P Kretzer, MD (1) · Mark Tidswell, MD (1) · Marla R Wolfson, PhD (1) · Michael D April, MD, PhD, MSc (1) · Nina Gentile, MD (1) · Robert Silbergleit, MD (1)
PMID 35381904, PMID 35967549, PMID 42377961
U24HL175258 (1), UG3HL175260 (1)