16 completed, 7 unknown, 5 terminated, 4 recruiting. 28 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 28 | Completed 13, Unknown 5, Recruiting 4, Terminated 4, Not yet recruiting 1, Withdrawn 1 |
| Phase 4 | 1 | Completed 1 |
Follow NIV: new trials by email Literature Review of NIV trials Research Report on NIV
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bedside Spirometry for Acute Lung Injury Hand-held spirometer, NIV - Respiratory Insufficiency | Not applicable | Recruiting | Centre Hospitalier Departemental Vendee | 30 | 2026-10-16 | 2026-10-19 |
| Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation - Acute Exacerbation of Chronic Obstructive Pulmonary Disease | Not applicable | Not yet recruiting | Hospital del Mar Research Institute (IMIM) | 14 | 2026-09-01 | 2026-08-25 |
| Noninvasive Ventilation Versus High-Flow Nasal Cannula After Extubation in High-Risk ICU Patients NIV, HFNC - Extubation Failure | Not applicable | Completed | Benha University | 102 | 2025-07-30 | 2026-06-11 |
| Noninvasive Technique and High Flow Nasal Oxygen in Respiratory Failure HFNC, NIV - Respiratory Failure | Not applicable | Recruiting | Minia University | 75 | 2025-06-01 | 2026-04-09 |
| Extracorporeal CO2 Removal for Acute Decompensation of COPD ECCO2R, NIV - Pulmonary Disease, Chronic Obstructive | Not applicable | Withdrawn | University of Bologna | 2024-08-01 | 2025-04-01 | |
| High Flow Nasal Oxygen for Exacerbation COPD HFNO, NIV - Acute Exacerbation of COPD | Not applicable | Recruiting | Franciscus Gasthuis | 40 | 2024-05-14 | 2025-08-21 |
| HFNC vs. NIV in Acute COPD Exacerbations NIV, HFNC-30, HFNC-50 - COPD Exacerbations, Acute Hypercapnic Respiratory Failure | Not applicable | Completed | Haseki Training and Research Hospital | 137 | 2023-09-01 | 2024-07-10 |
| Comparing High-flow Nasal Cannula Oxygen and Noninvasive Ventilation to Standard Oxygenation in Non-selected ICU Patients Admitted for Hypoxemic ARF Standard oxygen, HFNO, NIV - Acute Respiratory Failure | Not applicable | Terminated | University Hospital, Montpellier | 1470 | 2023-05-23 | 2026-06-23 |
| Effects of High-flow Oxygen Therapy and Non-invasive Ventilation on Lung Volumes and on Upper Airway HFNC, NIV - Respiratory Failure | Not applicable | Unknown | University Hospital, Montpellier | 56 | 2023-01-27 | 2024-05-29 |
| Use of PARniv for Early Diagnosis of LVF in AECOPD non invasive ventilation - Acute Heart Failure, COPD Exacerbation | Completed | University of Monastir | 80 | 2022-01-03 | 2022-05-27 | |
| Interest of Hypnosis When Setting up Non-invasive Ventilation in a Conscious Patient With COPD and/or Obesity With a BMI Greater Than 30, Suffering Fromacute Respiratory Distress in Adult Intensive Care Hypnosis + NIV, NIV - Chronic Obstructive Pulmonary Disease (COPD), Obesity With a BMI Greater Than 30 | Not applicable | Recruiting | Rennes University Hospital | 50 | 2021-11-20 | 2025-06-24 |
| RENOVATE Palliative: HFNC vs. Standard Respiratory Support in Patients With Do-Not-Intubate Order and ARF High Flow Nasal Cannula, Standard respiratory support - Care, Palliative, Respiratory Failure | Not applicable | Terminated | Hospital do Coracao | 3 | 2020-12-01 | 2021-08-16 |
| HFNC and NIV for COVID-19 Complicated by Respiratory Failure HFNC - Respiratory Failure | Completed | Chinese University of Hong Kong | 26 | 2020-06-11 | 2022-07-25 | |
| Non Invasive Ventilation With NAVA vs ASV for AECOPD Non invasive ventilation - Acute Exacerbation of COPD | Not applicable | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 76 | 2019-12-01 | 2021-08-09 |
| Sonographic Evaluation of Diaphragmatic Function Under Nasal High-flow (NHF) and Non-invasive Ventilation (NIV) in Respiratory Insufficiency Nasal high flow, NIV - Respiratory Insufficiency | Not applicable | Completed | Klinikum Emden | 35 | 2019-07-01 | 2025-07-03 |
| Analysis of Non-invasive Ventilatory Support Modes: High Flow Nasal Cannula and Non-invasive Ventilation High Flow Nasal cannula, NIV Noninvasive Ventilation - Asthma Acute | Not applicable | Unknown | University of Nove de Julho | 50 | 2019-01-10 | 2019-07-26 |
| Postoperative Noninvasive Ventilation After Upper Abdominal Surgery in Chronic Obstructive Lung Disease NIV - Acute Respiratory Failure Post Surgical (Diagnosis) | Not applicable | Completed | South Valley University | 100 | 2019-01-01 | 2021-05-07 |
| Oxygenation Methods and Non-invasive Ventilation in Patients With Acute Respiratory Failure and a do Not Intubate Order NIV, NFHC-O2 - Acute Respiratory Failure, Cancer | Unknown | Poitiers University Hospital | 330 | 2018-08-07 | 2018-09-28 | |
| High Flow Nasal Therapy Versus Noninvasive Ventilation in COPD Exacerbation HFNT, NIV - COPD Exacerbation | Not applicable | Completed | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo | 80 | 2018-02-15 | 2020-04-30 |
| Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients Noninvasive positive pressure ventilation, High flow oxygen nasal cannula - Post Extubation Respiratory Failure, Re-intubation | Not applicable | Completed | Mahidol University | 222 | 2017-05-01 | 2021-02-02 |
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Respiratory Insufficiency (12) · Pulmonary Disease, Chronic Obstructive (8) · Acidosis, Respiratory (2) · Heart Failure (2) · Hypercapnia (2) · Hypoxia (2) · Asthma (1) · COVID-19 (1) · Coronary Artery Disease (1) · Cystic Fibrosis (1) · Disease (1) · Dyspnea (1) · Heart Diseases (1) · Hematologic Neoplasms (1) · Motor Activity (1)
Poitiers University Hospital (2) · University Hospital, Montpellier (2) · Università Vita-Salute San Raffaele (2) · Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche (1) · Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo (1) · Benha University (1) · Centre Hospitalier Departemental Vendee (1) · Chinese University of Hong Kong (1) · Federal University of São Paulo (1) · Franciscus Gasthuis (1) · Guy's and St Thomas' NHS Foundation Trust (1) · Haseki Training and Research Hospital (1) · Hospital del Mar Research Institute (IMIM) (1) · Hospital do Coracao (1) · Institut für Pneumologie Hagen Ambrock eV (1)
France (8) · Italy (4) · Brazil (3) · Egypt (3) · Germany (3) · United Kingdom (2) · Belgium (1) · Greece (1) · Hong Kong (1) · India (1) · Kazakhstan (1) · Netherlands (1) · Spain (1) · Thailand (1) · Tunisia (1)
Adem Az, M.D. (1) · Alexandre B Cavalcanti, MD (1) · Bertien Buyse, MD,PhD (1) · Chun Pan, Dr (1) · David S Hui, MD (1) · Dirceu Costa (1) · Dorien Kiers, MD, PhD (1) · Dries Testelmans, MD, PhD (1) · Fernando Zampieri, MD (1) · Fuxi Sun, Dr (1) · Georg Nilius, MD (1)
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