8 unknown, 6 completed, 2 enrolling by invitation, 2 recruiting. 8 Not applicable, 2 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Unknown 3, Completed 2, Recruiting 2, Not yet recruiting 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 4 | 1 | Completed 1 |
Follow Mitral Valve Replacement: new trials by email Literature Review of Mitral Valve Replacement trials Research Report on Mitral Valve Replacement
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US) Mitral Valve Replacement - Mitral Regurgitation, Heart Disease | Not applicable | Recruiting | InnovHeart | 15 | 2026-08-05 | 2026-08-10 |
| The Feasibility Study of Polymer Artificial Heart Valve for the Treatment the Mitral Valve Disease. mitral valve replacement - Severe Mitral Valve Regurgitation, Severe Mitral Valve Stenosis | Not applicable | Recruiting | Shanghai HeartEpoch Medical Technology Co., Ltd | 10 | 2025-11-19 | 2026-07-06 |
| Outcomes of Complete Versus Partial Preservation of the Sub-valvular Apparatus in Cases of Mitral Valve Replacement mitral valve replacement - Mitral Valve Replacement, Mitral Insufficiency | Not applicable | Not yet recruiting | Assiut University | 80 | 2025-02-01 | 2025-02-06 |
| Influence of Original Native Mitral Valve Lesion (Stenosis or Steno-insufficiency vs. Insufficiency) on Post-implant Structural Bioprosthetic Degeneration After Mitral Valve Replacement Mitral valve replacement - Degeneration Mitral Bioprosthesis | Enrolling by invitation | Maastricht University Medical Center | 3500 | 2024-01-01 | 2025-09-03 | |
| Retrospective Clinical Data Collection on Carbomedics OptiForm Mitral Heart Valve Mitral Valve Replacement - Mitral Valve Disease | Unknown | Corcym S.r.l | 400 | 2023-11-23 | 2024-03-07 | |
| Clinical Investigation for the Foldax Tria Mitral Valve- India Mitral Valve Replacement - Mitral Valve Disease, Mitral Regurgitation | Not applicable | Unknown | Foldax, Inc | 70 | 2023-03-01 | 2024-01-05 |
| Bleeding and Blood Transfusion in MVR Mitral valve replacement - Mitral Valve Disease | Unknown | Assiut University | 40 | 2022-12-01 | 2022-10-26 | |
| Left Chamber Function in Mitral Regurgitation and Predicting Outcome After Replacement and Targeting for Early Surgery Mitral valve replacement, Speckle tracking echocardiography - Mitral Regurgitation | Not applicable | Unknown | Assiut University | 100 | 2021-09-20 | 2020-05-26 |
| Minimal Invasive Mitral Valve Replacement Versus Conventional Median Sternotomy Approach mitral valve replacement, conventional mitral valve replacement - Mitral Valve Disease | Unknown | Assiut University | 30 | 2020-04-01 | 2020-06-12 | |
| Long Term Results in Redo Mitral Valve Surgery After Mitral Valve Repair Mitral valve repair (PLM), Mitral valve replacement - Degenerative Mitral Valve Disease | Completed | Michele De Bonis | 108 | 2019-10-05 | 2023-05-03 | |
| Blood Transfusion Management in Patients With Mitral Valve Replacement in China Mitral valve replacement - Mitral Valve Replacement, Transfusion Reaction | Unknown | The Third Xiangya Hospital of Central South University | 2000 | 2019-09-16 | 2019-09-19 | |
| Transcatheter Versus Standard Surgical Mitral Valve Operation for Secondary Mitral Regurgitation Trancatheter Edge to Edge Repair, Mitral Valve Replacement, Restrictive Mitral Annuloplastie - Severe Mitral Valve Regurgitation (Disorder) | Enrolling by invitation | Centre Cardiologique du Nord | 600 | 2017-06-01 | 2026-05-19 | |
| Long Term Follow Up for CTSN Mitral Valve Repair Studies MV Repair, MV Replacement, CABG - Mitral Valve Insufficiency, Coronary Artery Disease | Active not recruiting | Icahn School of Medicine at Mount Sinai | 368 | 2017-05-03 | 2025-07-16 | |
| Mitral Valve Replacement With MValve Dock and Lotus mitral valve replacement - Mitral Valve Regurgitation | Not applicable | Unknown | MValve Technologies Ltd | 30 | 2016-06-01 | 2016-03-25 |
| Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System Mitral valve replacement - Mitral Valve Regurgitation | Not applicable | Completed | Shockwave Medical, Inc. | 27 | 2015-02-05 | 2026-07-24 |
| Surgical Treatment of Hypertrophic Obstructive Cardiomyopathy With Severe Mitral Insufficiency. myoectomy, Mitral valve surgery - Hypertrophic Obstructive Cardiomyopathy | Not applicable | Completed | Meshalkin Research Institute of Pathology of Circulation | 82 | 2013-10-01 | 2015-07-02 |
| Beating Versus Arrested Heart for Mitral Valve Replacement Mitral valve replacement, mitral valve replacement - Mitral Stenosis, Mitral Insufficiency | Phase 4 | Completed | Federal University of Bahia | 34 | 2010-04-01 | 2012-07-18 |
| Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery MVS, Ablation - Atrial Fibrillation, Mitral Valve Insufficiency | Phase 2 | Completed | Annetine Gelijns | 260 | 2010-01-01 | 2017-02-06 |
| Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation Mitral Valve Repair with Annuloplasty, Mitral Valve Replacement - Mitral Valve Insufficiency, Coronary Artery Disease | Phase 2 | Completed | Icahn School of Medicine at Mount Sinai | 251 | 2008-12-01 | 2019-03-15 |
| National Congenital Heart Disease Audit Cardiac Surgery, Therapeutic cardiac catheterisations procedures - Congenital Heart Disease (CHD) | Unknown | University College, London | 120000 | 2000-04-01 | 2016-11-04 |
Mitral Valve Insufficiency (12) · Mitral Valve Stenosis (4) · Coronary Artery Disease (2) · Gastroesophageal Reflux (2) · Atrial Fibrillation (1) · Cardiomyopathy, Hypertrophic (1) · Heart Defects, Congenital (1) · Heart Diseases (1) · Transfusion Reaction (1)
Assiut University (4) · Icahn School of Medicine at Mount Sinai (2) · Annetine Gelijns (1) · Centre Cardiologique du Nord (1) · Corcym S.r.l (1) · Federal University of Bahia (1) · Foldax, Inc (1) · InnovHeart (1) · MValve Technologies Ltd (1) · Maastricht University Medical Center (1) · Meshalkin Research Institute of Pathology of Circulation (1) · Michele De Bonis (1) · Shanghai HeartEpoch Medical Technology Co., Ltd (1) · Shockwave Medical, Inc. (1) · The Third Xiangya Hospital of Central South University (1)
United States (5) · Canada (4) · China (3) · Brazil (2) · Egypt (2) · France (2) · Belgium (1) · Germany (1) · India (1) · Italy (1) · Netherlands (1) · Poland (1) · Russia (1) · United Kingdom (1)
Annetine C. Gelijns, Ph.D. (2) · Patrick O'Gara, MD (2) · Timothy Gardner, MD (2) · Aleksandr V Bogachev-Prokophiev, PhD (1) · Annetine C Gelijns, PhD (1) · Anson Cheung, MD (1) · Francesco Nappi, MD (1) · Hamdy Shamseddin, PhD (1) · Richard Weisel, MD (1) · Rodney Franklin, MD (1) · Rong Gui (1) · Sara Gaggianesi (1)
PMID 24245543, PMID 25500293, PMID 25853744, PMID 26550689, PMID 27777294, PMID 28575282, PMID 30785252, PMID 31097163, PMID 31146872, PMID 33573741, PMID 39768667, PMID 39779262, PMID 40589299
U01HL088942 (3), 595 (1)