12 completed, 2 enrolling by invitation, 2 unknown, 1 not yet recruiting. 10 Phase 4, 3 Phase 1, 3 Phase 3, 2 Not applicable, 2 Phase 2.
Follow Metoprolol tartrate: new trials by email Literature Review of Metoprolol tartrate trials Research Report on Metoprolol tartrate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation) Verapamil Hydrochloride, Metoprolol tartrate - Atrial Fibrillation (AF), Atrial Fibrillation With Rapid Ventricular Response | Phase 4 | Not yet recruiting | Muhammad Ali Javed | 120 | 2027-01-01 | 2026-08-03 |
| Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) Placebo (matching), Beta-blockers - Heart Failure, HFpEF | Phase 4 | Enrolling by invitation | Weill Medical College of Cornell University | 240 | 2026-02-02 | 2026-10-16 |
| Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease atenolol, Metoprolol tartrate, Ivabradine - Coronary Arterial Disease (CAD), Ischemic Heart Disease (IHD) | Phase 2 / Phase 3 | Enrolling by invitation | Gødstrup Hospital | 350 | 2025-12-15 | 2025-12-17 |
| Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA Saline (NaCl), Metoprolol Tartrate - Coronary Arterial Disease (CAD), Angina (Stable) | Phase 4 | Recruiting | VZW Cardiovascular Research Center Aalst | 46 | 2025-07-03 | 2025-07-14 |
| Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis Caffeine, Metoprolol, Midazolam - Atopic Dermatitis | Early Phase 1 | Completed | Amgen | 21 | 2023-06-03 | 2025-12-23 |
| Impact of Beta-blockers on Physical Function in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2023-09-08 |
| Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2024-04-09 |
| Heart Rate Controller in Computed Tomography Coronary Angiography Metoprolol tartrate, Ivabradine, Diltiazem - Heart Rate, Coronary Computed Tomography Angiography | Phase 4 | Unknown | Mahidol University | 246 | 2021-01-30 | 2022-05-17 |
| Study in Healthy Subjects to Determine the Effect of Relacorilant on Exposure to Probe Substrates for Cytochrome P450s Midazolam hydrochloride, Metoprolol tartrate, Pioglitazone hydrochloride - Healthy | Phase 1 | Completed | Corcept Therapeutics | 27 | 2018-03-06 | 2018-05-17 |
| Evaluation of Bromocriptine, Metoprolol and Tamsulosin in Eyes With Non-Central DME Bromocriptine 2.5 MG, Metoprolol 25 MG, Tamsulosin 0.4 MG - Diabetic Macular Edema | Phase 1 / Phase 2 | Withdrawn | Andrew Moshfeghi, MD, MBA | 2018-03-01 | 2019-04-01 | |
| Metoprolol to Reduce Perioperative Myocardial Injury Metoprolol Tartrate, Placebo - Heart Diseases | Phase 3 | Completed | University of Chicago | 72 | 2016-12-01 | 2026-01-28 |
| Rate Control in Atrial Fibrillation Carvedilol, Metoprolol tartrate - Atrial Fibrillation | Phase 4 | Unknown | Creighton University | 20 | 2016-12-01 | 2016-06-16 |
| Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol. metoprolol, intravenous lipid emulsion, Sodium chloride 0.9% solution - lipid emulsion dummy - Drug Overdose, Overdose of Beta-adrenergic Blocking Drug | Phase 4 | Completed | Mikkel Bring Christensen | 10 | 2016-09-01 | 2017-04-12 |
| Efficacy and Safety of Metoprolol Tartrate Tablets Combined With Chinese Traditional Medicine on Premature Ventricular Complex. Tongmai Yangxin Pill (TMYXP), metoprolol tartrate, placebo - Premature Ventricular Contraction | Phase 4 | Completed | Xuanwu Hospital, Beijing | 584 | 2014-01-01 | 2021-08-17 |
| Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) Low-dose rtPA, Standard-dose rtPA, Intensive blood pressure (BP) lowering - Ischemic Stroke, High Blood Pressure | Phase 3 | Completed | The George Institute | 4587 | 2012-03-01 | 2021-10-13 |
| The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial Blood pressure management policies - Intracerebral Hemorrhage, Stroke | Not applicable | Completed | The George Institute | 2839 | 2008-09-01 | 2013-12-13 |
| Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Labetalol Hydrochloride, Metoprolol tartrate, Hydralazine Hydrochloride - CVA (Cerebrovascular Accident), Cerebral Hemorrhage | Not applicable | Completed | The George Institute | 404 | 2005-11-01 | 2008-06-26 |
| Black Education and Treatment of Hypertension (BEAT HTN) Hydrochlorothiazide, Lisinopril, Lisinopril and Hydrochlorothiazide - Hypertension | Phase 4 | Completed | Creighton University | 99 | 2005-08-01 | 2012-12-04 |
| Treatment of Supine Hypertension in Autonomic Failure Clonidine, Nitroglycerin transdermal, Dipyridamole/ Aspirin (Aggrenox) - Hypertension | Phase 1 | Completed | Vanderbilt University | 152 | 2001-01-01 | 2017-10-13 |
Hypertension (4) · Heart Diseases (3) · Heart Failure (3) · Atrial Fibrillation (2) · Cerebral Hemorrhage (2) · Coronary Artery Disease (2) · Heart Failure, Diastolic (2) · Stroke (2) · Angina Pectoris (1) · Angina, Stable (1) · Dermatitis, Atopic (1) · Drug Overdose (1) · Intracranial Hemorrhages (1) · Ischemic Stroke (1) · Multiple System Atrophy (1)
The George Institute (3) · Weill Medical College of Cornell University (3) · Creighton University (2) · Amgen (1) · Andrew Moshfeghi, MD, MBA (1) · Corcept Therapeutics (1) · Gødstrup Hospital (1) · Mahidol University (1) · Mikkel Bring Christensen (1) · Muhammad Ali Javed (1) · University of Chicago (1) · VZW Cardiovascular Research Center Aalst (1) · Vanderbilt University (1) · Xuanwu Hospital, Beijing (1)
United States (10) · Australia (3) · Belgium (2) · China (2) · Denmark (2) · Argentina (1) · Austria (1) · Brazil (1) · Chile (1) · Finland (1) · France (1) · Germany (1) · Hong Kong (1) · India (1) · Italy (1)
Craig Anderson, PhD (2) · Parag Goyal, MD (2) · Andrew A. Moshfeghi, MD, MBA (1) · Andrew Ambrosy, MD, MPH (1) · Bruce Neal, PhD (1) · Craig S Anderson, MD (1) · Italo Biaggioni, MD (1) · Kirsteen Donaldson, FFPM,DM,FRCP (1) · Mikkel B Christensen, MD, PhD (1) · Pallavi Bellamkonda, MBBS (1) · Parag Goyal, MD, MSc (1) · Peter Nagele, MD (1) · Prichapol Thantassanee, M.D. (1)
PMID 32640944, PMID 25503550, PMID 25589782, PMID 25657175, PMID 25712944, PMID 25823544, PMID 26746184, PMID 27165954, PMID 27178897, PMID 27919055, PMID 30890109, PMID 31085948, PMID 33598552, PMID 38018833, PMID 40541207, PMID 41855454, PMID 42848972, PMID 10851208, PMID 11927799, PMID 12119802, PMID 12923400, PMID 15738343, PMID 16391172, PMID 16533484, PMID 18396107, PMID 18426998, PMID 19047577, PMID 19738158, PMID 20823381, PMID 22129475, PMID 22678090, PMID 22744655, PMID 22801444, PMID 23266540, PMID 23713578, PMID 24149007, PMID 24530176, PMID 25497513, PMID 25677598, PMID 25801872, PMID 26044442, PMID 26202097, PMID 26265125, PMID 26810526, PMID 26814235, PMID 26846860, PMID 26859491, PMID 27009893, PMID 27073236, PMID 27143274
2025 (1), K76AG064428 (1), R01AG091005 (1), R01HL126892 (1)