14 completed. 14 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 14 | Completed 14 |
Follow methylnaltrexone: new trials by email Literature Review of methylnaltrexone trials Research Report on methylnaltrexone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methylnaltrexone Pharmacokinetics in Neurointensive Care Patients Methylnaltrexone - Opioid Use, Unspecified With Other Opioid-induced Disorder | Phase 1 | Completed | University of Zurich | 9 | 2014-02-01 | 2016-10-26 |
| Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time. Loperamide placebo, Loperamide, Colon Transit - Intestinal Obstruction | Phase 1 | Completed | University Medicine Greifswald | 16 | 2011-05-01 | 2012-05-11 |
| Evaluate the Pharmacokinetics (PK) of Methylnaltrexone (MNTX) in Healthy Adult Subjects Methylnaltrexone bromide - Healthy Adult Subjects | Phase 1 | Completed | Bausch Health Americas, Inc. | 20 | 2010-07-01 | 2019-11-29 |
| Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects Loperamide, Loperamide placebo, Methylnaltrexone placebo - Intestinal Obstruction | Phase 1 | Completed | University Medicine Greifswald | 15 | 2010-01-01 | 2016-10-26 |
| Effect of Cimetidine on the Single-Dose PK of IV- Administered MNTX methylnaltrexone - Healthy Adult Subjects | Phase 1 | Completed | Bausch Health Americas, Inc. | 18 | 2007-01-01 | 2019-11-27 |
| Study of Pharmacokinetics, Safety and Tolerability of Intravenous Methylnaltrexone Bromide methylnaltrexone, placebo - Healthy Adults | Phase 1 | Completed | Bausch Health Americas, Inc. | 28 | 2006-10-01 | 2019-11-27 |
| Effects of MNTX on CYP450 2D6 in Metabolizers of Dextromethorphan SC Methylnaltrexone (MNTX), IV Methylnaltrexone (MNTX), Oral Paroxetine - Healthy Adults | Phase 1 | Completed | Bausch Health Americas, Inc. | 54 | 2006-03-01 | 2019-11-27 |
| Study of the Pharmacokinetics of Intravenous Administered 14C-MNTX IV methylnaltrexone (MNTX) - Healthy Male Volunteers | Phase 1 | Completed | Bausch Health Americas, Inc. | 6 | 2005-06-01 | 2019-11-27 |
| Effect of Methylnaltrexone (MNTX) on Electrocardiogram (ECG) Parameters and Cardiac Repolarization Methylnaltrexone (MNTX), Placebo, Moxifloxacin - Healthy Volunteers | Phase 1 | Completed | Bausch Health Americas, Inc. | 546 | 2004-11-01 | 2019-11-29 |
| Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone (MNTX) in Subjects With Impaired Renal Function Methylnaltrexone (MNTX) - Renal Impairment | Phase 1 | Completed | Bausch Health Americas, Inc. | 32 | 2004-03-01 | 2019-11-27 |
| Pharmacokinetics and Bioavailability Comparison of Two Different Formulations of MNTX Tablets MNTX tablet (Formulation 1), MNTX tablet (Formulation 2) - Normal Volunteers | Phase 1 | Completed | Bausch Health Americas, Inc. | 24 | 2004-02-01 | 2019-11-27 |
| Tolerance and Pharmacokinetics Study of MNTX Tablets Oral methylnaltrexone, Oral placebo - Normal Healthy Volunteers | Phase 1 | Completed | Bausch Health Americas, Inc. | 37 | 2003-10-01 | 2019-11-27 |
| Naloxone and Intravenous Methylnaltrexone Effects on Bladder Function Naloxone, IV Methylnaltrexone (MNTX), Placebo - Healthy Males | Phase 1 | Completed | Bausch Health Americas, Inc. | 15 | 2002-10-01 | 2023-04-12 |
| Pharmacokinetics and Bioavailability of Single Subcutaneous Doses of Methylnaltrexone Versus Intravenous Dose SC Methylnaltrexone (MNTX), IV Methylnaltrexone (MNTX) - Healthy Subjects | Phase 1 | Completed | Bausch Health Americas, Inc. | 6 | 2002-06-01 | 2019-11-27 |
Intestinal Obstruction (2) · Renal Insufficiency (1)
Bausch Health Americas, Inc. (11) · University Medicine Greifswald (2) · University of Zurich (1)
United States (11) · Germany (2) · Switzerland (1)
Tage Ramakrishna, MD (11) · Natascia Corti, MD (1)