6 completed, 6 unknown, 1 not yet recruiting, 1 withdrawn. 4 Early Phase 1, 4 Not applicable, 4 Phase 3, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 4 | Completed 2, Not yet recruiting 1, Withdrawn 1 |
| Not applicable | 4 | Completed 2, Unknown 2 |
| Phase 3 | 4 | Unknown 4 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Unknown 1 |
| Phase 4 | 1 | Completed 1 |
Follow Melatonin 5 MG: new trials by email Literature Review of Melatonin 5 MG trials Research Report on Melatonin 5 MG
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison Between the Effect of Two Different Doses of Oral Melatonin on Sleep Quality After Total Hip Arthroplasty Melatonin 5 MG, Melatonin 10 MG, Placebo - Sleep Disturbance | Early Phase 1 | Not yet recruiting | Benha University | 150 | 2026-08-04 | 2026-07-29 |
| Melatonin on Post Operative Pain After CS Melatonin 5 mg, Melatonin 10 mg, Placebo - Pain Management, Pain After Surgery | Not applicable | Completed | Benha University | 60 | 2025-10-10 | 2026-07-14 |
| Improving Sleep Quality After Total Joint Arthroplasty ( TJA) Melatonin 5 mg, Placebo Oral Tablet, Magnesium 500Mg Oral Tablet - Pain After TJA | Early Phase 1 | Withdrawn | Stanford University | 2025-06-01 | 2025-04-11 | |
| Melatonin on Anxiety and Sleep Quality in Adults Undergoing Coronary Artery Bypass Graft Surgery Placebo, Melatonin 5 MG - Melatonin, Anxiety | Not applicable | Unknown | Ain Shams University | 30 | 2024-02-01 | 2024-02-02 |
| TKA Melatonin and Sleep Quality Melatonin 5 mg, Placebo (Vitamin C) - Arthroplasty, Replacement | Not applicable | Completed | Hospital for Special Surgery, New York | 176 | 2022-01-10 | 2023-09-14 |
| The Role of Preoperative Melatonin in Reducing the Inhaled Isoflurane Requirements in Open Nephrectomy Melatonin 5 mg, Sugar Coated Tablets - Postoperative Pain | Early Phase 1 | Completed | Cairo University | 30 | 2021-07-15 | 2022-07-20 |
| Melatonin Use After Primary Total Joint Arthroplasty Melatonin 5 mg, Placebo - Osteo Arthritis Knee | Phase 1 | Completed | NYU Langone Health | 294 | 2021-07-12 | 2025-05-04 |
| The Impact of Air Travel on Passenger Cognitive Functions Citicoline, Cytochrome C6, Sodium Chloride Oral Product - Air Travel | Phase 2 / Phase 3 | Unknown | Dinara Zhumanbayeva | 50 | 2021-06-01 | 2021-03-17 |
| Melatonin and Osteogenic Loading on Osteopenia Melatonin 5 mg, Osteogenic loading, Mock for Osteogenic Loading - Osteopenia | Early Phase 1 | Completed | Duquesne University | 27 | 2020-07-02 | 2026-10-22 |
| Efficacy of the Administration of Melatonin 5mg in the Prevention of Delirium in Older Adults Hospitalized in the Emergency Department Melatonin 5 mg - Delirium in Old Age | Not applicable | Unknown | Universidad Autonoma de San Luis Potosà | 145 | 2019-10-10 | 2019-12-05 |
| Exogenous Melatonin in Intensive Care Unit Chronodisruption Melatonin 5 mg, Placebo Oral Tablet - Sleep Deprivation, Intensive Care Psychosis | Phase 3 | Unknown | Saint-Joseph University | 98 | 2018-11-15 | 2024-02-14 |
| Clinical Trial of Antioxidant Therapy in Patients With Septic Shock Melatonin 5 mg, Vitamin C 1 GM Oral Tablet, Vitamin E 400 UNT - Oxidative Stress, Septic Shock | Phase 3 | Unknown | American British Cowdray Medical Center | 131 | 2018-07-23 | 2021-08-10 |
| Melatonin as Adjuvant Treatment for ADHD in Adults Melatonin 5 mg - Attention Deficit Hyperactivity Disorder | Phase 3 | Unknown | Hospital Israelita Albert Einstein | 120 | 2017-09-01 | 2018-08-15 |
| Effect of Melatonin on Sleep Quality in Patients Dementia Melatonin 5 mg, Placebo - Sleep Disorders, Dementia | Phase 4 | Completed | Hospital Universitario Dr. Jose E. Gonzalez | 40 | 2016-01-15 | 2017-02-28 |
Sleep Initiation and Maintenance Disorders (2) · Agnosia (1) · Anxiety Disorders (1) · Attention Deficit Disorder with Hyperactivity (1) · Bone Diseases, Metabolic (1) · Dementia (1) · Pain, Postoperative (1) · Parasomnias (1) · Sepsis (1) · Shock, Septic (1) · Sleep Deprivation (1) · Sleep Wake Disorders (1)
Benha University (2) · Ain Shams University (1) · American British Cowdray Medical Center (1) · Cairo University (1) · Dinara Zhumanbayeva (1) · Duquesne University (1) · Hospital Israelita Albert Einstein (1) · Hospital Universitario Dr. Jose E. Gonzalez (1) · Hospital for Special Surgery, New York (1) · NYU Langone Health (1) · Saint-Joseph University (1) · Stanford University (1) · Universidad Autonoma de San Luis Potosà (1)
Egypt (4) · United States (4) · Mexico (2) · Brazil (1) · Lebanon (1)
Alejandro G Della Valle, MD (1) · Alfredo Aisa Alvarez, MD (1) · Antonio Gordillo, PhD (1) · Derek Amanatullah, M.D. PhD (1) · Guillermo Guajardo, MD (1) · Joshua C Rozell, MD (1) · Paula Witt-Enderby, PhD (1)
PMID 33189083, PMID 34674490, PMID 37174730, PMID 38401621, PMID 41059603