12 completed, 1 not yet recruiting, 1 recruiting, 1 unknown. 15 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 15 | Completed 12, Not yet recruiting 1, Recruiting 1, Unknown 1 |
Follow LPS: new trials by email Literature Review of LPS trials Research Report on LPS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Spleen Preservation Versus Splenectomy in Left Pancreatectomy for Pancreatic Ductal Adenocarcinoma (SPLENDID) SPLP, LPS - Pancreatic Cancer, Pancreatectomy | Not applicable | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 360 | 2026-11-01 | 2026-09-02 |
| Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function Short-Chain Fatty Acid Colon-Delivery Capsules, Placebo capsules, Lipopolysaccharide (LPS) - Endotoxemia, Inflammation | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 56 | 2025-10-24 | 2026-07-20 |
| Determining the Fingerprint of Endotoxin Tolerance Endotoxin (E. coli O:113, Reference Endotoxin) - Endotoxemia, Sepsis | Not applicable | Completed | Radboud University Medical Center | 110 | 2019-05-27 | 2025-02-07 |
| Intradermal LPS and Antibiotics Erythromycin 4% topical gel formulation:, Clindamycin 1% lotion formulation:, Prednisolone tablet (0.5mg/kg; parallel comparison): - Inflammation; Skin | Not applicable | Completed | Centre for Human Drug Research, Netherlands | 32 | 2018-10-12 | 2021-08-03 |
| The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells LPS, Placebo - Sepsis, Endotoxemia, Immunosuppression | Not applicable | Completed | Radboud University Medical Center | 12 | 2018-01-05 | 2022-10-06 |
| The Effects of Preceding LPS Administration on the Fluenz-induced Immune Response Fluenz, placebo, LPS - Innate Immune Response, Immune Tolerance | Not applicable | Completed | Radboud University Medical Center | 30 | 2015-12-01 | 2019-05-14 |
| Endotoxin-induced Inflammatory and Behavioral Responses and Predictors of Individual Differences Endotoxin, Placebo - Sickness Behavior | Not applicable | Completed | Karolinska Institutet | 22 | 2015-02-01 | 2015-08-20 |
| A Study of Intracellular Signaling in Muscle and Fat Cells During Ketosis LPS - Ketoacidosis, Diabetes Mellitus Type 1 | Not applicable | Completed | University of Aarhus | 9 | 2014-06-01 | 2015-12-02 |
| The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia Endotoxin, Vancomycin, Metronidazole, Ciprofloxacin - Endotoxemia | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 16 | 2014-06-01 | 2015-12-30 |
| Whey Protein Study - Identification of Sustainable Satiety Control, HPL, LPL - Satiety | Not applicable | Completed | University of Aberdeen | 13 | 2013-08-01 | 2016-03-24 |
| Inflammation and Brain Function - Main Study Endotoxin, Placebo - Sickness Behavior | Not applicable | Completed | Karolinska Institutet | 52 | 2010-10-01 | 2018-06-11 |
| Effects of Iron Loading and Iron Chelation Therapy on Innate Immunity During Human Endotoxemia iron sucrose, Deferasirox, endotoxin - Systemic Inflammatory Process, Anemia | Not applicable | Completed | Radboud University Medical Center | 30 | 2010-02-01 | 2015-11-17 |
| Inflammatory Markers in Sputum After LPS Inhalation LPS - Inflammation | Not applicable | Unknown | Centre Hospitalier Universitaire Brugmann | 12 | 2010-01-01 | 2010-03-05 |
| Inflammation and Brain Function - Pilot Study Lipopolysaccharide, Placebo - Sickness Behavior | Not applicable | Completed | Karolinska Institutet | 8 | 2009-10-01 | 2018-06-11 |
| Inflammation and the Metabolic Syndrome in Humans Endotoxin (LPS) - Metabolic Syndrome X | Not applicable | Completed | University of Pennsylvania | 50 | 2003-08-01 | 2017-03-30 |
Endotoxemia (5) · Illness Behavior (3) · Inflammation (3) · Sepsis (2) · Anemia (1) · Dermatitis (1) · Diabetes Mellitus, Type 1 (1) · Inhibition, Psychological (1) · Ketosis (1) · Metabolic Syndrome (1) · Pancreatic Neoplasms (1) · Van der Woude syndrome (1)
Radboud University Medical Center (4) · Karolinska Institutet (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Centre Hospitalier Universitaire Brugmann (1) · Centre for Human Drug Research, Netherlands (1) · Universitaire Ziekenhuizen KU Leuven (1) · University of Aarhus (1) · University of Aberdeen (1) · University of Pennsylvania (1)
Netherlands (5) · Belgium (2) · Denmark (1) · United Kingdom (1) · United States (1)
Alexandra Johnstone, Dr (1) · Boushra Dalile, PhD (1) · Jony van Hilst, MD, PhD (1) · Kristin Verbeke, PhD (1) · Lukas Van Oudenhove, MD, PhD (1) · Mads Svart, MD (1) · Marc G. Besselink, MD, PhD (1) · Matthijs Moerland, PhD (1) · Mohammad Abu Hilal, MD, PhD (1) · Muredach P. Reilly, MB, MSCE (1) · Peter Pickkers, MD, PhD (1) · Peter Pickkers, Prof. Dr. (1) · W. J. Wiersinga, MD, PhD (1)
PMID 27307305, PMID 27331367, PMID 28389705, PMID 29298938, PMID 30217536, PMID 30418539, PMID 33074729
R01HL073278 (1)