26 completed, 3 terminated, 2 not yet recruiting, 2 recruiting. 15 Not applicable, 13 Phase 1, 3 Early Phase 1, 3 Phase 4, 2 Phase 2.
Follow LPS: new trials by email Literature Review of LPS trials Research Report on LPS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Spleen Preservation Versus Splenectomy in Left Pancreatectomy for Pancreatic Ductal Adenocarcinoma (SPLENDID) SPLP, LPS - Pancreatic Cancer, Pancreatectomy | Not applicable | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 360 | 2026-11-01 | 2026-09-02 |
| Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function Short-Chain Fatty Acid Colon-Delivery Capsules, Placebo capsules, Lipopolysaccharide (LPS) - Endotoxemia, Inflammation | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 56 | 2025-10-24 | 2026-07-20 |
| Brain Biomarker on Inflammation Response LPS, Placebo - Schizophrenia | Phase 1 | Withdrawn | University of Maryland, Baltimore | 2025-01-01 | 2023-12-05 | |
| Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia Dexamethasone, Tocilizumab, Anakinra - Sepsis, Neuroinflammatory Response | Phase 4 | Unknown | Radboud University Medical Center | 52 | 2024-10-24 | 2025-04-04 |
| Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma Lipopolysaccharides - Asthma; Eosinophilic, Asthma | Phase 1 | Not yet recruiting | National Jewish Health | 60 | 2024-04-01 | 2024-02-21 |
| Neural Response to Inflammatory Challenge in Major Depressive Disorder LPS, Saline - Major Depressive Disorder | Phase 1 / Phase 2 | Recruiting | Laureate Institute for Brain Research, Inc. | 180 | 2021-05-15 | 2026-04-21 |
| CBD-Microglia PET Study [11C]PBR28, Low-dose lipopolysaccharide, Intradermal Capsaicin - CBD, Healthy | Early Phase 1 | Completed | Yale University | 28 | 2021-05-07 | 2026-04-29 |
| Determining the Fingerprint of Endotoxin Tolerance Endotoxin (E. coli O:113, Reference Endotoxin) - Endotoxemia, Sepsis | Not applicable | Completed | Radboud University Medical Center | 110 | 2019-05-27 | 2025-02-07 |
| A Study Exploring the Use of Vaccine and Antigen Challenges for Immune Monitoring in Healthy Participants Imvanex, Shingrix, LPS - Healthy | Early Phase 1 | Completed | Janssen Research & Development, LLC | 48 | 2019-04-08 | 2025-02-03 |
| Intradermal LPS and Antibiotics Erythromycin 4% topical gel formulation:, Clindamycin 1% lotion formulation:, Prednisolone tablet (0.5mg/kg; parallel comparison): - Inflammation; Skin | Not applicable | Completed | Centre for Human Drug Research, Netherlands | 32 | 2018-10-12 | 2021-08-03 |
| Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease LPS - Alzheimer Disease | Early Phase 1 | Completed | Yale University | 18 | 2018-04-15 | 2024-02-05 |
| First-time-in-Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single (in Both Fed and Fasted States) or Repeat Doses of GSK3358699 Placebo, GSK3358699, GM-CSF - Arthritis, Rheumatoid | Phase 1 | Terminated | GlaxoSmithKline | 48 | 2018-03-13 | 2020-12-02 |
| The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells LPS, Placebo - Sepsis, Endotoxemia, Immunosuppression | Not applicable | Completed | Radboud University Medical Center | 12 | 2018-01-05 | 2022-10-06 |
| Imaging the Neuroimmune System in PTSD Lipopolysaccharide - Post Traumatic Stress Disorder | Phase 1 | Completed | Yale University | 34 | 2017-03-28 | 2024-12-09 |
| Adrecizumab-LPS Study Endotoxin, Placebo, Adrecizumab - Healthy Volunteers | Phase 1 | Completed | Adrenomed AG | 24 | 2017-01-04 | 2021-02-01 |
| Dose-Related Inflammatory Effects of Intravenous Endotoxin in Humans Endotoxin, Placebo - Healthy | Phase 1 | Completed | Robert J Noveck, M.D. | 23 | 2016-08-01 | 2017-04-11 |
| Vorapaxar in the Human Endotoxemia Model Vorapaxar, Placebo, LPS - Healthy Volunteers | Phase 4 | Completed | Medical University of Vienna | 16 | 2016-06-01 | 2020-01-10 |
| The Effects of Preceding LPS Administration on the Fluenz-induced Immune Response Fluenz, placebo, LPS - Innate Immune Response, Immune Tolerance | Not applicable | Completed | Radboud University Medical Center | 30 | 2015-12-01 | 2019-05-14 |
| Endotoxin-induced Inflammatory and Behavioral Responses and Predictors of Individual Differences Endotoxin, Placebo - Sickness Behavior | Not applicable | Completed | Karolinska Institutet | 22 | 2015-02-01 | 2015-08-20 |
| A Study of Intracellular Signaling in Muscle and Fat Cells During Ketosis LPS - Ketoacidosis, Diabetes Mellitus Type 1 | Not applicable | Completed | University of Aarhus | 9 | 2014-06-01 | 2015-12-02 |
Showing 20 of 36. Sign in to see all of them.
Endotoxemia (9) · Inflammation (4) · Sepsis (4) · Illness Behavior (3) · Asthma (2) · Alzheimer Disease (1) · Anemia (1) · Arthritis, Rheumatoid (1) · Depressive Disorder, Major (1) · Dermatitis (1) · Diabetes Mellitus, Type 1 (1) · Hypersensitivity (1) · Infections (1) · Inhibition, Psychological (1) · Ketosis (1)
Radboud University Medical Center (8) · Yale University (4) · Karolinska Institutet (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · GlaxoSmithKline (2) · Medical University of Vienna (2) · University of North Carolina, Chapel Hill (2) · Adrenomed AG (1) · Centre Hospitalier Universitaire Brugmann (1) · Centre for Human Drug Research, Netherlands (1) · Janssen Research & Development, LLC (1) · Laureate Institute for Brain Research, Inc. (1) · National Jewish Health (1) · Pfizer (1) · Robert J Noveck, M.D. (1)
United States (11) · Netherlands (10) · Belgium (3) · United Kingdom (3) · Austria (2) · Denmark (1)
Peter Pickkers, MD, PhD (3) · Kelly Cosgrove, PhD (2) · Adam Mecca, M.D., Ph.D. (1) · Alexandra Johnstone, Dr (1) · Bart P Ramakers, MD (1) · Bernd Jilma, MD (1) · Boushra Dalile, PhD (1) · Christa Firbas, MD (1) · David B Peden, MD, MS (1) · David Peden, MD (1) · Jony van Hilst, MD, PhD (1) · Kristin Verbeke, PhD (1) · L E Hong, M.D. (1)
PMID 22129171, PMID 25883989, PMID 27307305, PMID 27331367, PMID 28389705, PMID 29298938, PMID 29382797, PMID 30217536, PMID 30418539, PMID 33074729, PMID 34773923
1RC1ES018417 (1), 2017 (1), 2023 (1), K23AG057794 (1), R01HL073278 (1), R01MH110674 (1)