40 completed, 9 unknown, 2 withdrawn, 1 active not recruiting. 27 Not applicable, 15 Phase 4, 5 Phase 3, 3 Phase 1, 2 Phase 2.
Follow Local anesthetic: new trials by email Literature Review of Local anesthetic trials Research Report on Local anesthetic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stem Cells vs. Steroids for Discogenic Back Pain Autologous stem cells, Corticosteroid, Local anesthetic - Chronic Low Back Pain, Degenerative Disc Disease | Not applicable | Withdrawn | Johns Hopkins University | 2025-09-30 | 2025-10-07 | |
| Rectus Sheath Catheters Following Midline Laparotomy Ropivacaine 0.2%, Saline 0.9% - Acute Abdomen, Ileus | Not applicable | Not yet recruiting | Asklepios Kliniken Hamburg GmbH | 40 | 2025-07-01 | 2025-08-01 |
| Effects of Local Ketamine in Orthognathic Procedures Ketamine, Articaine Hydrochloride + Epinephrine - Dentofacial Deformities, Analgesia | Not applicable | Active not recruiting | Bezmialem Vakif University | 40 | 2025-06-21 | 2026-03-27 |
| Comparison of Intraperitoneal Bupivacaine Alone or With Dexmedetomidine Bupivacaine injection, Dexmedetomidine injection - LAPAROSCOPIC CHOLECYSTECTOMY | Not applicable | Completed | RESnTEC, Institute of Research | 68 | 2024-01-01 | 2024-08-21 |
| Predictive Factors for the Effectiveness of the Ilioinguinal Iliohypogastric Nerve Block for Hernia Surgery Ilioinguinal-Iliohypogastric nerve block, Local anesthetic - Hernia Inguinal, Pain Postoperative | Completed | University of Padova | 343 | 2023-10-13 | 2025-05-07 | |
| Serratus Intercostal Block Versus Epidural/Port Infiltration Analgesia in Eventration: Prospective Non Inferiority Study undergo, ultrasound, Local anesthetic - Eventration, Regional Anesthesia | Phase 4 | Completed | Hospital del Rio Hortega | 160 | 2023-10-01 | 2026-06-08 |
| QUALHYBOM Hypnosis Versus Equimolar Mixture of Oxygen and Nitrous Oxide (MEOPA) During a Bone Marrow Biopsy: a Clinical, Controlled, Randomized, Multicenter Study Hypnosis, Local anesthetic - Bone Marrow Biopsy | Not applicable | Completed | Rennes University Hospital | 180 | 2023-06-19 | 2025-06-26 |
| Photobiomodulation for Controlling Pre-Local Anesthetic Injection Pain Photobiomodulation, Mepivacaine hydrochloride in combination with epinephrine, Photobiomodulation simulation - Fear Needles | Not applicable | Completed | University of Nove de Julho | 50 | 2023-02-15 | 2024-07-18 |
| Dexmedetomedine and Ketamine in Erector Spinae Block for Postoperative Analgesia Following Mastectomy. Bupivacaine Hydrochloride, Bupivacaine Hydrochloride and dexmedetomedine, Bupivacaine Hydrochloride and ketamine - Breast Cancer | Phase 2 / Phase 3 | Completed | National Cancer Institute, Egypt | 75 | 2023-01-01 | 2023-06-08 |
| Comparing Autologous Blood, Corticosteroid, and Their Combined Injection for Treating Lateral Epicondylitis Corticosteroid, Autologous Blood, Local Anesthetic - Lateral Epicondylitis, Comparing Autologous Blood Corticosteroid and Their Combined Injection for Treating Lateral Epicondylitis | Not applicable | Completed | Istanbul Training and Research Hospital | 119 | 2023-01-01 | 2024-02-01 |
| Erector Spinae Plane Block and Ankle and Foot Surgery Ultrasound, Bupivacaine Hydrochloride, saline solution - Pain, Ankle Injuries | Not applicable | Completed | Fayoum University Hospital | 68 | 2023-01-01 | 2023-10-04 |
| Cryoneurolysis for TKA - a Pilot Study Iovera - Cryoneurolysis, Local anesthetic - Knee Pain Chronic, Osteoarthritis | Not applicable | Unknown | Unity Health Toronto | 20 | 2022-12-01 | 2023-05-12 |
| Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block Fentanyl, Propofol, Rocuronium - Pain, Postoperative, Hip Dysplasia | Not applicable | Unknown | Tanta University | 85 | 2022-09-29 | 2022-09-30 |
| Regional Anesthesia in Total Hip and Knee Arthroplasty Bupivacaine, Ropivacaine, Mepivacaine - Knee Osteoarthritis, Hip Osteoarthritis | Phase 4 | Unknown | Ottawa Hospital Research Institute | 135 | 2022-09-01 | 2022-08-08 |
| Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment NITESGON, Lidocaine / Prilocaine Topical Cream, C5/C6 stimulation - Mild Cognitive Impairment, Memory Impairment | Phase 1 / Phase 2 | Completed | University of Dublin, Trinity College | 80 | 2022-09-01 | 2026-01-26 |
| Articaine vs Lidocaine for Pediatric Dental Procedures lidocaine, articaine - Anesthesia, Dental, Pain, Postoperative | Phase 4 | Withdrawn | Boston University | 2022-09-01 | 2022-11-03 | |
| Comparison of the Efficacy of Prolotherapy Injection Therapy & Local Anesthetic Injection Therapy. Dextrose solution, Lidocain - Myofascial Pain Syndrome of Neck | Not applicable | Completed | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | 28 | 2022-08-01 | 2023-12-13 |
| Blind Fascia Iliaca Compartment Block Compared to Ultrasound-guided Femoral Nerve Block in Patients With Hip Fractures Fascia Iliaca Compartment Block, Femoral Nerve Block, Ropivacaine - Hip Fractures | Unknown | University Hospital, Linkoeping | 100 | 2022-05-01 | 2022-05-09 | |
| Development of Effective, Opioid Sparing Techniques for Peri-operative Pain Management of Transgender Patients Undergoing Gender Affirming Surgeries Ultrasound guided Continuous Infraclavicular Brachial Plexus Block, Ultrasound guided Continuous Femoral Nerve Block, Ultrasound guided Pudendal Nerve Block - Gender Dysphoria | Phase 3 | Recruiting | Cedars-Sinai Medical Center | 640 | 2021-11-11 | 2025-09-17 |
| Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment Local anesthetic - Endodontic Disease, Post Operative Pain | Phase 4 | Completed | University of Washington | 35 | 2021-09-29 | 2025-05-29 |
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Pain, Postoperative (13) · Agnosia (9) · Pain (4) · Breast Neoplasms (3) · Acute Pain (2) · Chronic Pain (2) · Postoperative Nausea and Vomiting (2) · Abdomen, Acute (1) · Ankle Injuries (1) · Ankylosis (1) · Atrophy (1) · Bursitis (1) · Cognitive Dysfunction (1) · Colorectal Neoplasms (1) · Coronary Artery Disease (1)
University of Parma (6) · Assiut University (3) · Ottawa Hospital Research Institute (2) · Rennes University Hospital (2) · Ain Shams University (1) · Albert Einstein College of Medicine (1) · Aretaieion University Hospital (1) · Asklepios Kliniken Hamburg GmbH (1) · Bezmialem Vakif University (1) · Bispebjerg Hospital (1) · Boston University (1) · CES University (1) · Cedars-Sinai Medical Center (1) · Dr Madeleine Wilwerth (1) · Fayoum University Hospital (1)
Italy (9) · United States (8) · Egypt (7) · Brazil (5) · Turkey (Türkiye) (5) · Canada (3) · Spain (3) · France (2) · Greece (2) · Sweden (2) · Belgium (1) · China (1) · Colombia (1) · Denmark (1) · Germany (1)
Guido Fanelli, MD (3) · Andrea Cornini, MD (2) · Giorgio Danelli, MD (2) · Marco Baciarello, MD (2) · Anna Carolina Horliana, PhD (1) · Avina Paranjpe (1) · Benoit Godey, PH-PD (1) · Bryant Tran, MD (1) · Daniel Wilhelms, PhD, MD (1) · Dheeraj Rajan, MD, FRCPC (1) · Dimitris Tousoulis, MD PhD (1) · Ehab H Shaker, MD (1) · Emad Kamel Said, MD (1)
PMID 24165901, PMID 24289799, PMID 25977992, PMID 30204683, PMID 30609276, PMID 31014382, PMID 31021882, PMID 33585141, PMID 34002866, PMID 34590307, PMID 35086112, PMID 36117569, PMID 38550709, PMID 38963583, PMID 39400883, PMID 42484702