9 completed, 1 recruiting, 1 terminated, 1 unknown. 6 Not applicable, 6 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 6 |
| Phase 2 | 6 | Completed 3, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow L-leucine: new trials by email Literature Review of L-leucine trials Research Report on L-leucine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Leucine in Midlife Depression L-leucine, L-lysine - Major Depression | Phase 2 | Recruiting | Emory University | 75 | 2025-02-01 | 2026-09-11 |
| Effects of Intragastric Quinine, Alone or Combined With L-leucine, on Postprandial Glycaemic Control Quinine, L-leucine, Combination of quinine and L-leucine - Healthy | Not applicable | Completed | University of Adelaide | 15 | 2023-02-02 | 2024-12-10 |
| Plasma Trimethylamine N-oxide Elevation Induced by L-carnitine Supplementation and Insulin Resistance L-carnitine, L-leucine, Change of the circadian cycle - Insulin Resistance | Not applicable | Completed | Poznan University of Physical Education | 40 | 2022-02-07 | 2026-08-17 |
| Carnitine Supplementation and Bone Mineral Density L-carnitine, L-leucine - Osteoporosis | Not applicable | Completed | Poznan University of Physical Education | 36 | 2017-09-01 | 2022-08-16 |
| Rapid Antidepressant Effects of Leucine L-Leucine, Maltodextrin - Major Depressive Disorder | Phase 2 | Terminated | University of Texas Southwestern Medical Center | 16 | 2017-03-09 | 2023-01-26 |
| The Effect of Leucine on Carnitine Transport to Skeletal Muscle L-carnitine, L-leucine - Muscle Loss | Not applicable | Completed | Gdansk University of Physical Education and Sport | 16 | 2016-10-01 | 2021-08-17 |
| Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults Essential Amino Acids (EAA), Placebo (Alanine) - Muscle Atrophy, Quality of Life | Phase 2 | Completed | University of Oregon | 80 | 2014-12-01 | 2024-07-23 |
| L-leucine in Diamond Blackfan Anemia Patients L-leucine - Diamond Blackfan Anemia | Phase 2 | Unknown | Federal Scientific Clinical Centre of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogache | 30 | 2014-09-01 | 2015-03-11 |
| Dose Comparisons of Leucine-Metformin Combinations on Blood Glucose Levels In Type 2 Diabetic Patients Low Metformin, Metformin, Mid Metformin - Type 2 Diabetes Mellitus | Phase 2 | Completed | NuSirt Biopharma | 96 | 2014-07-01 | 2018-02-27 |
| Dietary Intake and Circulating Levels of Branched Chain Amino Acids Diet high in amino acid levels, Diet low in amino acid levels - Dietary Intake of Branched Chain Amino Acids | Not applicable | Completed | Massachusetts General Hospital | 5 | 2014-04-01 | 2016-10-07 |
| Pilot Phase I/II Study of Amino Acid Leucine in Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia leucine - Diamond Blackfan Anemia, Blackfan Diamond Syndrome | Phase 1 / Phase 2 | Completed | Northwell Health | 55 | 2013-06-01 | 2022-12-02 |
| Estrogen and Serotonin on Changing Brain Chemistry estrogen patch, Amino acids, Placebo Patch - Menopause | Not applicable | Completed | University of Colorado, Denver | 47 | 2010-03-04 | 2021-04-02 |
Anemia, Diamond-Blackfan (2) · Depressive Disorder, Major (2) · Inflammation (2) · Muscular Atrophy (2) · Anemia, Hypoplastic, Congenital (1) · Depression (1) · Depressive Disorder, Treatment-Resistant (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Insulin Resistance (1) · Memory Disorders (1) · Osteoporosis (1) · Red-Cell Aplasia, Pure (1)
Poznan University of Physical Education (2) · Emory University (1) · Federal Scientific Clinical Centre of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogache (1) · Gdansk University of Physical Education and Sport (1) · Massachusetts General Hospital (1) · Northwell Health (1) · NuSirt Biopharma (1) · University of Adelaide (1) · University of Colorado, Denver (1) · University of Oregon (1) · University of Texas Southwestern Medical Center (1)
United States (7) · Poland (2) · Australia (1) · Russia (1)
Robert Olek, PhD (2) · Adrianna Vlachos, MD (1) · Christine Feinle-Bisset, PhD (1) · Cynthia Neill Epperson, M.D. (1) · Ebrahim Haroon, MD (1) · Geoffrey Walford, M.D. (1) · Madhukar H Trivedi, M.D. (1) · Orville G Kolterman, MD (1)
PMID 26733251, PMID 26781817, PMID 26829246, PMID 30280129, PMID 31343947, PMID 33025707, PMID 37533033, PMID 41365468
P50MH099910 (1), R01AG046401 (1), R01MH132059 (1)