9 completed, 2 not yet recruiting, 1 active not recruiting. 12 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 9, Not yet recruiting 2, Active not recruiting 1 |
| Phase 1 | 3 | Not yet recruiting 2, Active not recruiting 1 |
| Phase 3 | 1 | Completed 1 |
Follow istradefylline: new trials by email Literature Review of istradefylline trials Research Report on istradefylline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury Istradefylline, low oxygen therapy - Spinal Cord Injuries, Myelopathy | Phase 1 / Phase 2 | Not yet recruiting | Randy Trumbower, PT, PhD | 40 | 2027-09-01 | 2026-03-20 |
| Enhancing Rehabilitation in Aging Study (ERAS) Istradefylline 20 mg, Placebo, Acute Intermittent Hypoxia (AIH) - Adults | Phase 1 / Phase 2 | Not yet recruiting | University of Florida | 38 | 2026-10-01 | 2026-07-15 |
| Adenosine 2A Receptor Antagonism and AIH in ALS Consume 20mg of istradefylline, Low Oxygen therapy, Placebo counterpart to the istradefylline drug - ALS | Phase 1 / Phase 2 | Active not recruiting | University of Florida | 40 | 2022-06-21 | 2026-03-27 |
| A Phase 2b Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa Istradefylline, Placebo - Parkinson's Disease | Phase 2 | Completed | Kyowa Kirin Co., Ltd. | 363 | 2007-03-01 | 2012-08-29 |
| A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease Istradefylline (KW-6002) - Parkinson's Disease | Phase 2 | Completed | Kyowa Kirin Co., Ltd. | 64 | 2005-11-01 | 2012-08-29 |
| Study of Istradefylline (KW-6002) for the Treatment of Restless Legs Syndrome Istradefylline (KW-6002) - Sleep Disorder, Restless Legs Syndrome | Phase 2 | Completed | Kyowa Kirin, Inc. | 160 | 2005-07-01 | 2024-04-25 |
| A Study of Istradefylline (KW-6002) as Monotherapy in Parkinson's Disease (PD) Patients Istradefylline (KW-6002) - Parkinson's Disease, Movement Disorder Syndrome | Phase 2 | Completed | Kyowa Kirin, Inc. | 160 | 2005-05-01 | 2024-04-25 |
| A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa Istradefylline (KW-6002) - Parkinson's Disease | Phase 2 | Completed | Kyowa Kirin Co., Ltd. | 75 | 2005-04-01 | 2014-05-23 |
| A Long-Term, Safety Study With a Flexible Dose Range of KW-6002 in Patients With Motor Response Complications on Levodopa/Carbidopa Therapy istradefylline - Parkinson's Disease | Phase 2 / Phase 3 | Completed | Kyowa Kirin, Inc. | 2002-08-01 | 2024-04-25 | |
| 12-Week, Double-Blind, Placebo-Controlled, Randomized Study of the Efficacy of 40 mg/Day KW-6002 in Parkinson's Disease Patients on Levodopa/Carbidopa KW-6002 (istradefylline) - Parkinson's Disease | Phase 2 | Completed | Kyowa Kirin, Inc. | 180 | 2002-04-01 | 2024-04-25 |
| 12-Week, Double-Blind, Placebo-Controlled Study of 20 and 60 mg/Day Istradefylline in Parkinson's Disease Patients on Levodopa/Carbodopa Istradefylline (KW-6002) - Parkinson's Disease | Phase 2 | Completed | Kyowa Kirin, Inc. | 325 | 2002-03-01 | 2024-04-25 |
| KW-6002 to Treat Parkinson's Disease KW-6002, IV Levodopa - Parkinson's Disease | Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 16 | 2000-10-01 | 2008-03-04 |
Parkinson Disease (8) · Dyskinesias (1) · Hypoxia (1) · Movement Disorders (1) · Respiratory Aspiration (1) · Restless Legs Syndrome (1) · Sleep Wake Disorders (1) · Spinal Cord Diseases (1) · Spinal Cord Injuries (1)
Kyowa Kirin, Inc. (5) · Kyowa Kirin Co., Ltd. (3) · University of Florida (2) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Randy Trumbower, PT, PhD (1)
United States (8) · Japan (3)
Neil Sussman, MD (3) · Barbara Smith (1) · James Williams, MD (1) · Randy D Trumbower, PT, PhD (1)