40 completed, 11 unknown, 6 terminated, 6 withdrawn. 28 Not applicable, 16 Phase 2, 9 Phase 3, 9 Phase 4, 7 Phase 1.
Follow Hypertonic Saline: new trials by email Literature Review of Hypertonic Saline trials Research Report on Hypertonic Saline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Rhinovirus Hospitalization and Investigation of Nasal-airway Omics (RHINO) Study Nasal Swab Healthy Surveillance, Nasal Swab Sick Samples, Nasal Swab Hospitalized Cohort - Rhinovirus | Recruiting | University of Wisconsin, Madison | 670 | 2026-08-04 | 2026-08-10 | |
| Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome Mannitol, Hypertonic Saline - Arginine Vasopressin Deficiency, Primary Polydipsia | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 144 | 2026-06-16 | 2026-06-18 |
| The Effects of Performing a Motor Imagery Task on Cortical Excitability During Acute Experimental Muscle Pain and Acute Itch Hypertonic Saline, Histamine, Cowhage - Itch, Pain | Not applicable | Recruiting | Aalborg University | 30 | 2024-10-01 | 2024-11-22 |
| Investigation of Corticospinal Excitability Aspects of Itch and Pain Hypertonic Saline, Histamine, Cowhage - Itch, Pain | Not applicable | Completed | Aalborg University | 30 | 2024-07-01 | 2024-11-22 |
| Benefits of Inhalation of Hypertonic Saline Solution Prior to Physiotherapy ELTGOL Technique in Bronchiectasis Hypertonic saline, Isotonic saline, ELTGOL - Bronchiectasis Adult | Phase 3 | Recruiting | Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta | 57 | 2024-06-01 | 2024-07-03 |
| Sodium Lactate Versus Hypertonic Saline Solution in the Treatment of Intracranial Hypertensive Episodes in Severe Brain Injured Patients Lactate, Sodium, Hypertonic saline - Intra Cerebral Hypertension, Lactate Sodium Solution | Phase 3 | Unknown | University Hospital, Geneva | 52 | 2024-01-01 | 2023-10-31 |
| Nebulised 3% Hypertonic Saline Versus 0.9% Saline for Treating Patients Hospitalized With Acute Bronchiolitis Hypertonic saline, Normal saline - Bronchiolitis | Not applicable | Completed | Szpital im. Św. Jadwigi Śląskiej | 180 | 2023-11-01 | 2025-05-18 |
| Influence of Osmotic Stimulation of Vasopressin on Autonomic Function Hypertonic Saline, Normal Saline - Water Stress, Body Water Dehydration | Not applicable | Withdrawn | University of North Carolina, Greensboro | 2023-11-01 | 2023-11-13 | |
| Investigating Composite Biomarkers for Pain Catastrophizing hypertonic saline, isotonic saline - Pain, Acute | Not applicable | Unknown | Aalborg University | 44 | 2022-10-15 | 2024-02-02 |
| Hypertonic Saline for MAC Hypertonic saline, Azithromycin, Ethambutol - Nontuberculous Mycobacterial Lung Disease, Nontuberculous Mycobacterium Infection | Phase 4 | Recruiting | Oregon Health and Science University | 50 | 2021-05-18 | 2026-10-20 |
| Comparison of Cow Milk and 15% Hypertonic Saline in the Treatment of Rectal Prolapse in Children Hypertonic saline, Cow Milk - Rectal Prolapse | Early Phase 1 | Completed | Shaheed Zulfiqar Ali Bhutto Medical University | 80 | 2021-02-01 | 2023-12-18 |
| The Aim of This Study is to Compare the Efficacy of Perioperative Hypertonic Saline 3% Versus Normal Saline (0.9%) in Decreasing Recurrence Risk in Non-muscle Invasive Bladder Cancer Hypertonic Saline - TCC | Phase 2 | Unknown | Kaplan Medical Center | 150 | 2021-01-20 | 2021-02-18 |
| Activation of miRNA and Proteins After Acute Experimental Pain. (miRNA: Micro RNA) hypertonic saline, Saline injection, Blood sampling - Hypertonic Saline, Isotonic Saline | Not applicable | Completed | Aalborg University | 20 | 2020-11-01 | 2023-10-03 |
| Hypertonic Saline Inhalation in Acute Bronchiolitis normal saline and salbutamol, hypertonic saline and salbutamol, Hypertonic saline - Acute Bronchiolitis | Phase 4 | Unknown | Assiut University | 75 | 2020-07-20 | 2020-02-11 |
| Effect of Short-term Motor Training on Accuracy and Precision of Knee Movement in Human With and Without Knee Pain Hypertonic saline, isotonic saline, Motor training - Isotonic Saline, Hypertonic Saline | Not applicable | Completed | Aalborg University | 60 | 2019-10-30 | 2021-01-13 |
| Randomized, Controlled Trial of Hyperosmotlar Saline for Rotator Cuff Repair Irrigation Solution Hypertonic saline - Arthroscopic Shoulder Surgery, Rotator Cuff Tear | Phase 4 | Unknown | Rothman Institute Orthopaedics | 100 | 2019-01-01 | 2018-11-13 |
| Furosemide Alone or Unexpectedly With Solution of Hypertonic Saline in Nephrotic Syndrome Hypertonic saline, Furosemide Injection - Nephrotic Syndrome | Not applicable | Unknown | Medical University of Bialystok | 30 | 2018-12-15 | 2022-11-23 |
| Comparison Between Two Concentration of Hypertonic Saline in Intestinal Obstruction Surgery Hypertonic saline - Intestinal Obstruction Fluid Management With Hypertonic Saline | Not applicable | Unknown | Cairo University | 50 | 2018-11-01 | 2018-11-14 |
| Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure Hypertonic Saline Solution, Placebo - Acute Decompensated Heart Failure | Not applicable | Unknown | University of Monastir | 600 | 2018-07-01 | 2023-05-16 |
| Randomised Open Label Trial of Hypertonic Saline and Carbocisteine in Bronchiectasis (CLEAR) Hypertonic saline, Carbocysteine 750 MG - Bronchiectasis | Phase 3 | Completed | Belfast Health and Social Care Trust | 288 | 2018-06-27 | 2025-05-02 |
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Cystic Fibrosis (13) · Bronchiolitis (8) · Brain Injuries, Traumatic (5) · Pain (4) · Brain Edema (3) · Intracranial Hypertension (3) · Kidney Diseases (3) · Bronchiectasis (2) · Diabetes Insipidus (2) · Pruritus (2) · Pulmonary Disease, Chronic Obstructive (2) · Respiratory Sounds (2) · Stroke (2) · Acute Pain (1) · Agnosia (1)
Aalborg University (5) · Parion Sciences (3) · Regional Hospital Holstebro (3) · The Hospital for Sick Children (3) · Assiut University (2) · Belfast Health and Social Care Trust (2) · Joseph Zabner (2) · University of North Carolina, Chapel Hill (2) · Adelaida Lamas Ferreiro (1) · Ahmed Mohamed ELbadawy (1) · Beth Israel Deaconess Medical Center (1) · Cairo University (1) · Children's Hospital Los Angeles (1) · Direction Centrale du Service de Santé des Armées (1) · Dr. Michael Flavin (1)
United States (24) · Denmark (9) · Canada (6) · Egypt (5) · United Kingdom (4) · Poland (3) · France (2) · Spain (2) · Switzerland (2) · Argentina (1) · Brazil (1) · Germany (1) · India (1) · Ireland (1) · Israel (1)
Karl Donn (2) · Achikam Oren-Grinberg, MD (1) · Adelaida Lamas, MD (1) · Ahmed ELbadawy, MD (1) · Alicja Rydzewska-Rosolowska, MD (1) · Alison Church, MD (1) · Alyssa H Silver, MD (1) · Angela K Lumba, MD (1) · Beth L Laube, PhD (1) · Daniel Davis, MD (1) · Ehab H Shaker, MD (1) · Eileen M Bulger, MD (1) · Ellen R Wald, MD (1) · Erling B Pedersen, DMSc (1) · Erling B Pedersen, MD, DMSc (1)
PMID 15654403, PMID 16421364, PMID 16860701, PMID 19245725, PMID 20100768, PMID 20630539, PMID 21841534, PMID 21896198, PMID 22413805, PMID 22579125, PMID 22777113, PMID 24067081, PMID 24088993, PMID 24093893, PMID 24862623, PMID 24970686, PMID 25784523, PMID 26553190, PMID 31200756, PMID 31327670, PMID 32669217, PMID 32671834, PMID 34020114, PMID 34674574, PMID 36453122, PMID 37014057, PMID 37319354, PMID 37660715, PMID 38011984, PMID 40255927
2015 (2), P50HL084934 (1), R01AI182200 (1), R01AT001415 (1), R01CA120228 (1), U01AI126610 (1), U01HL131046 (1)