45 completed, 25 unknown, 19 recruiting, 11 terminated. 62 Not applicable, 17 Phase 2, 10 Phase 1, 9 Phase 3, 4 Phase 4.
Follow Hyperbaric Oxygen Therapy: new trials by email Literature Review of Hyperbaric Oxygen Therapy trials Research Report on Hyperbaric Oxygen Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of HBOT on Femoral Head Avascular Necrosis (AVN) Hyperbaric Oxygen Therapy - Osteonecrosis, Avascular Necrosis | Not applicable | Not yet recruiting | Yale University | 400 | 2026-12-01 | 2026-07-01 |
| Hyperbaric Oxygen Therapy as Adjunctive Treatment for Fracture-Related Infection Hyperbaric Oxygen Therapy - Fracture Related Infection, Hyperbaric Oxygenation | Phase 2 | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 50 | 2026-08-01 | 2026-04-16 |
| Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy Hyperbaric Oxygen Therapy, Conventional therapy group - Acute Ischemic Stroke | Not applicable | Recruiting | Beijing Chao Yang Hospital | 424 | 2026-07-22 | 2026-07-24 |
| Hyperbaric Oxygen Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Hyperbaric oxygen therapy, SHAM treatment - Chronic Fatigue Syndrome, ME/CFS | Not applicable | Recruiting | Assaf-Harofeh Medical Center | 74 | 2026-07-19 | 2026-08-21 |
| Hyperbaric Oxygen Therapy to Improve Autologous Fat Graft Intake in Irradiated Breast Hyperbaric Oxygen Therapy, Control - Breast Reconstruction, Lipofilling | Not applicable | Recruiting | University Hospital, Geneva | 16 | 2026-03-01 | 2026-05-14 |
| the Efficacy of Hyperbaric Oxygen on Acute Ankle Sprain hyperbaric oxygen therapy, non Hyperbaric Oxygen Therapy - Ankle Sprain | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 208 | 2026-03-01 | 2026-02-12 |
| Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder - a Pragmatic, Double Blinded Randomized Trial Hyperbaric Oxygen Therapy - PTSD - Post Traumatic Stress Disorder | Not applicable | Recruiting | Medical Corps, Israel Defense Force | 72 | 2026-03-01 | 2026-03-16 |
| Evaluating Whether Hyperbaric Oxygen Therapy Can Improve VO₂-Max and Reduce Inflammation Markers in Healthy Adults Ages 30-60. Hyperbaric Oxygen Therapy - Cardiovascular Fitness, Inflammation | Not applicable | Recruiting | University of Texas at Austin | 30 | 2026-01-01 | 2026-01-23 |
| Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy for the Treatment of Post COVID Condition Hyperbaric Oxygen therapy - Long COVID, Post Acute Sequelae of COVID-19 | Not applicable | Recruiting | University Health Network, Toronto | 120 | 2026-01-01 | 2026-02-23 |
| A Prospective, Single-center, Randomized Controlled Clinical Study Evaluating the Efficacy and Safety of Hyperbaric Oxygen Therapy as an Adjunctive Treatment for Chronic Heart Failure hyperbaric oxygen therapy - Chronic Heart Failure With Reduced Ejection Fraction | Not applicable | Not yet recruiting | Fujian Medical University | 150 | 2025-12-15 | 2025-12-30 |
| Concept-verification Clinical Trial on the Inhibition of Breast Cancer Lung Metastasis Progression by Hyperbaric Oxygen Hyperbaric Oxygen Therapy - Breast Cancer, Lung Metastasis | Not applicable | Enrolling by invitation | Jinan Central Hospital | 10 | 2025-11-24 | 2026-04-07 |
| Hyperbaric Oxygen Treatment for Necrotizing Fasciitis and Necrotizing Soft Tissue Infections Hyperbaric Oxygen Therapy - Necrotizing Fascitis | Not applicable | Not yet recruiting | Corewell Health West | 160 | 2025-11-14 | 2025-09-12 |
| Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy Hyperbaric Oxygen Therapy - TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2025-10-01 | 2025-10-09 |
| The Effect of Hyperbaric Oxygen Therapy on Circulating Hematopoietic Stem Cell Population Hyperbaric Oxygen Therapy - Circulating Hematopoietic Stem Cells | Not applicable | Recruiting | Assaf-Harofeh Medical Center | 60 | 2025-03-05 | 2026-04-21 |
| Hyperbaric Oxygen Therapy on Insulin Resistance in Postmenopause Hyperbaric oxygen therapy, Hypoglycemic Drug - Insulin Resistance Syndrome | Phase 1 / Phase 2 | Recruiting | Cairo University | 40 | 2025-01-28 | 2025-02-04 |
| Optimal Number of Hyperbaric Oxygen Treatments for Carbon Monoxide Poisoning Hyperbaric Oxygen Therapy - Hyperbaric Oxygen Therapy, Carbon Monoxide Poisoning | Not applicable | Terminated | University of Alberta | 2 | 2025-01-24 | 2026-03-13 |
| Treatment of Post-COVID-19 With Hyperbaric Oxygen Therapy: a Randomized, Controlled Trial Hyperbaric oxygen - Post-COVID-19 Syndrome, Post-COVID Syndrome | Phase 3 | Unknown | Erasmus Medical Center | 120 | 2024-10-01 | 2024-02-28 |
| The Efficacy of Hyperbaric Oxygen-assisted Treatment for ASUC and Refractory IBD Administration of methylprednisolone sodium succinate, Hyperbaric Oxygen Therapy - Ulcerative Colitis | Not applicable | Enrolling by invitation | Xijing Hospital of Digestive Diseases | 44 | 2024-09-30 | 2025-12-02 |
| The Effect of Hyperbaric Oxygen Therapy for Acceleration Recovery After Anterior Cruciate Ligament Reconstruction(ACLR) hyperbaric oxygen therapy - Anterior Cruciate Ligament Reconstruction | Not applicable | Recruiting | Assaf-Harofeh Medical Center | 40 | 2024-09-15 | 2026-04-22 |
| Hyperbaric Oxygen Therapy Used on Severely Injured Healthy Individuals With Fungal Infections Hyperbaric Oxygen Therapy - Invasive Fungal Infections, Hyperbaric Oxygen Therapy | Active not recruiting | Assaf-Harofeh Medical Center | 7 | 2024-08-04 | 2025-08-13 |
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Brain Injuries, Traumatic (8) · Carbon Monoxide Poisoning (6) · Diabetes Mellitus (6) · Post-Concussion Syndrome (6) · Brain Concussion (5) · COVID-19 (5) · Cognitive Dysfunction (5) · Autistic Disorder (4) · Brain Injuries (4) · Breast Neoplasms (4) · Diabetic Foot (4) · Inflammation (4) · Post-Acute COVID-19 Syndrome (4) · Colitis, Ulcerative (3) · Hyperoxia (3)
Assaf-Harofeh Medical Center (17) · Cairo University (3) · Paul G. Harch, M.D. (3) · Wonju Severance Christian Hospital (3) · Jinling Hospital, China (2) · Kafrelsheikh University (2) · National Baromedical Services (2) · RWTH Aachen University (2) · Shandong Provincial Hospital (2) · University Hospital, Geneva (2) · University of Maryland, Baltimore (2) · University of Versailles (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Aswan University Hospital (1) · Azienda Policlinico Umberto I (1)
United States (41) · Israel (19) · China (11) · Egypt (6) · Canada (5) · France (5) · Netherlands (4) · Australia (3) · Italy (3) · South Korea (3) · Germany (2) · Mexico (2) · Poland (2) · Switzerland (2) · Austria (1)
Paul G Harch, M.D. (3) · Amir Hadanny, MD (2) · Dick Clarke, CHT (2) · Matthias Knobe, MD (2) · Ahmed Khocht, DDS (1) · Andrew Wakefield, MD (1) · Angela M Cheung, MD, PhD (1) · Bing Xiong (1) · Brett Hart, MD (1) · Brian Rowe, MD, MSc, CCFP (EM), FCCP (1) · Chen-Yu Chen, Master (1) · Daniel A Rossignol, MD (1) · Daniel F Kalbermatten, MD, PhD (1) · Daria O'Reilly, PhD (1)
PMID 15183555, PMID 16554123, PMID 17439697, PMID 18005455, PMID 19298750, PMID 19949909, PMID 20456243, PMID 20497028, PMID 20680427, PMID 26740639, PMID 27524654, PMID 28029181, PMID 28545109, PMID 28982834, PMID 29453383, PMID 30831142, PMID 31002414, PMID 31409407, PMID 32189664, PMID 32574226, PMID 33246494, PMID 33518452, PMID 34074856, PMID 34357432, PMID 35133516, PMID 36525683, PMID 37256885, PMID 38329746, PMID 38834296, PMID 38961397, PMID 39289760, PMID 39298511, PMID 39425927, PMID 39566051, PMID 40083556, PMID 40545548, PMID 40847457
2019 (1), U01DK134321 (1)