10 completed, 6 terminated, 6 unknown, 1 active not recruiting. 25 Phase 2, 5 Phase 1, 5 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 25 | Completed 10, Terminated 6, Unknown 6, Active not recruiting 1, Recruiting 1, Withdrawn 1 |
| Phase 1 | 5 | Completed 2, Unknown 2, Terminated 1 |
| Phase 3 | 5 | Terminated 3, Completed 2 |
Follow Hyperbaric oxygen: new trials by email Literature Review of Hyperbaric oxygen trials Research Report on Hyperbaric oxygen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Long-Term Outcomes Following HBOT Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, Post-Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 35 | 2026-06-18 | 2026-07-28 |
| Safety and Efficacy of Hyperbaric Oxygen Therapy for Long COVID Syndrome Hyperbaric oxygen, Sham treatment - COVID-19, Post COVID-19 Condition | Phase 2 | Completed | Karolinska University Hospital | 80 | 2021-09-15 | 2024-08-22 |
| Hyperbaric Oxygen and Outcome After Below Knee Amputations Hyperbaric Oxygen - Amputation; Postoperative, Sequelae | Phase 1 / Phase 2 | Terminated | Duke University | 4 | 2021-01-01 | 2025-08-11 |
| Hyperbaric Oxygen as an Adjuvant Treatment for Patients With Covid-19 Severe Hypoxemia Hyperbaric Oxygen - Covid19 | Phase 2 | Terminated | Asociación Argentina de Medicina Hiperbárica e Investigación | 40 | 2020-07-06 | 2021-01-15 |
| Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19 Hyperbaric oxygen - SARS (Severe Acute Respiratory Syndrome), Cytokine Storm | Phase 2 / Phase 3 | Terminated | Karolinska Institutet | 34 | 2020-06-03 | 2023-01-09 |
| Hyperbaric Oxygen Therapy After Stroke - PILOT Hyperbaric oxygen - Cerebral Stroke | Phase 2 | Withdrawn | Norwegian Underwater Intervention (NUI) | 2020-04-20 | 2020-04-27 | |
| Hyperbaric Oxygen Treatment in Humans With Gram Positive Cocci Endocarditis Hyperbaric oxygen - Infectious Endocarditis | Phase 2 | Unknown | Ole Hyldegaard | 10 | 2019-12-01 | 2020-12-31 |
| Hyperbaric Radiation Sensitization of Head and Neck Cancers Hyperbaric oxygen, Hyperbaric chamber - Squamous Cell Carcinoma of the Head and Neck | Phase 2 | Unknown | National Baromedical Services | 400 | 2019-07-01 | 2019-02-18 |
| A Randomized Phase II Study of Hyperbaric Oxygen in Improving Engraftment in Umbilical Cord Blood Stem Cell Transplant Hyperbaric oxygen - AML, NHL | Phase 2 | Active not recruiting | University of Rochester | 64 | 2019-02-28 | 2026-07-20 |
| Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury Hyperbaric Oxygen, Minimal pressure air - Brain Injury, Chronic | Phase 2 | Completed | Lindell Weaver | 49 | 2017-09-06 | 2022-08-04 |
| Treatment of Human Cord Blood Mononuclear Cell for Delayed Encephalopathy After Carbon Monoxide Poisoning Human cord blood mononuclear cell, hyperbaric oxygen - Delayed Encephalopathy After Carbon Monoxide Poisoning | Phase 1 / Phase 2 | Unknown | Liaocheng People's Hospital | 60 | 2016-10-01 | 2017-04-18 |
| Hyperbaric Oxygen Therapy for Lung Transplantation Hyperbaric Oxygen Therapy, Endobronchial Biopsy of Airway Epithelium - Disorder Related to Lung Transplantation, Central Airway Stenosis | Phase 2 | Completed | Duke University | 20 | 2015-02-01 | 2023-11-18 |
| The Effect of Hyperbaric Oxygen Therapy on Inflammatory Parameters Induced by a Heat Injury Model Hyperbaric oxygen - Secondary Hyperalgesia, Inflammation | Phase 2 | Completed | Copenhagen University Hospital, Rigshospitalet | 26 | 2015-02-01 | 2019-06-21 |
| Hyperbaric Oxygen for Ulcerative Colitis Hyperbaric oxygen, Sham Hyperbaric Air - Ulcerative Colitis | Phase 2 / Phase 3 | Terminated | Dartmouth-Hitchcock Medical Center | 18 | 2013-08-01 | 2018-04-06 |
| Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial Hyperbaric Oxygen - Cystitis, Radio Induced | Phase 2 / Phase 3 | Completed | Göteborg University | 75 | 2012-08-01 | 2019-06-26 |
| Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI) hyperbaric oxygen, sham hyperbaric air - Post-concussive Symptoms, Traumatic Brain Injury | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 79 | 2011-02-01 | 2014-09-05 |
| Efficacy of Hyperbaric Oxygen Therapy in the Treatment of Osteoradionecrosis hyperbaric oxygen - Osteoradionecrosis | Phase 2 / Phase 3 | Terminated | Radboud University Medical Center | 20 | 2009-10-01 | 2025-09-15 |
| Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy Hyperbaric oxygen @ 2.4 ATA, Sham treatment - Brain Injury, Chronic | Phase 1 / Phase 2 | Completed | San Antonio Military Medical Center | 50 | 2009-02-01 | 2018-08-13 |
| Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A Randomized Clinical Study Hyperbaric oxygen - Osteoradionecrosis | Phase 2 | Unknown | Lone Forner | 114 | 2008-06-01 | 2012-05-25 |
| Hyperbaric Oxygen for the Treatment of a Dry Mouth Which Occurred After Radiotherapy Hyperbaric oxygen - Radiation-induced Xerostomia | Phase 2 | Terminated | Thomas Kuhnt | 13 | 2008-05-01 | 2016-10-27 |
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Brain Injuries, Traumatic (3) · COVID-19 (3) · Post-Concussion Syndrome (3) · Brain Injury, Chronic (2) · Osteoradionecrosis (2) · Stress Disorders, Post-Traumatic (2) · Brain Concussion (1) · Breast Neoplasms (1) · Carbon Monoxide Poisoning (1) · Central Nervous System Neoplasms (1) · Colitis, Ulcerative (1) · Crush Injuries (1) · Cystitis (1) · Cytokine Release Syndrome (1) · Endocarditis, Subacute Bacterial (1)
Duke University (2) · Asociación Argentina de Medicina Hiperbárica e Investigación (1) · Barrett Cancer Center (1) · Bayside Health (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dartmouth-Hitchcock Medical Center (1) · Göteborg University (1) · Hull University Teaching Hospitals NHS Trust (1) · Institute of Cancer Research, United Kingdom (1) · Karolinska Institutet (1) · Karolinska University Hospital (1) · Liaocheng People's Hospital (1) · Lindell Weaver (1) · Lone Forner (1) · National Baromedical Services (1)
United States (11) · Sweden (5) · Denmark (4) · United Kingdom (3) · Germany (2) · Norway (2) · Argentina (1) · Australia (1) · Austria (1) · Canada (1) · Chile (1) · China (1) · Czechia (1) · Finland (1) · India (1)
Peter Lindholm, MD, PhD (2) · Anders Kjellberg, MD (1) · Anders Kjellberg, MD, PhD (1) · Ara A. Chalian, MD (1) · Corey A Siegel, MD, MS (1) · E. George Wolf, M.D. (1) · Fabrizio Verdini, MD (1) · Francois Dieleman, MD DMD (1) · Hans Kaanders, MD PhD (1) · Ian L Millar, MBBS (1) · James R Hussey, PhD (1) · James Wells, MD (1) · Jeysen Z Yogaratnam, MB.BCh, BAO, MRCS (1) · John R. Yarnold, MD, FRCR (1) · Judith Bruchfeld, MD, PhD (1)
PMID 16457083, PMID 16510383, PMID 19949909, PMID 20129356, PMID 20954243, PMID 23335971, PMID 24471697, PMID 25401463, PMID 28357821, PMID 30402285, PMID 31394602, PMID 31394603, PMID 31537473, PMID 33518452, PMID 34226219, PMID 36670365, PMID 37510965, PMID 39393522, PMID 40228859, PMID 40291346
2019 (1)