22 completed, 3 not yet recruiting, 3 unknown, 1 active not recruiting. 9 Phase 4, 7 Not applicable, 5 Early Phase 1, 5 Phase 1, 4 Phase 2.
Follow Human Insulin: new trials by email Literature Review of Human Insulin trials Research Report on Human Insulin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dose Response Study of Transdermal Human Insulin in Patients Human Insulin, Finger-actuated, Metered Pump Sprayer - Glucose, High Blood | Phase 2 / Phase 3 | Not yet recruiting | Transdermal Delivery Solutions Corp | 30 | 2027-09-02 | 2026-05-26 |
| Peripheral Vascular Effects of Insulin in Obesity human insulin - Obesity (BMI>30), Insulin Resistance | Early Phase 1 | Not yet recruiting | University of Missouri-Columbia | 64 | 2026-12-01 | 2026-10-15 |
| Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity human insulin - Obesity (BMI>30), Insulin Resistance | Early Phase 1 | Not yet recruiting | University of Missouri-Columbia | 64 | 2026-12-01 | 2026-10-15 |
| Effect of Topical Insulin on Healing Rate of Pemphigus Lesions insulin glargine, human insulin, 0.9% Normal Saline - Pemphigus Vulgaris, Skin Erosion | Phase 2 | Completed | Alexandria University | 20 | 2024-06-22 | 2026-03-10 |
| Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation Carbon dioxide breathing, Neurovascular Coupling, Human insulin - Healthy, Vasodilation | Early Phase 1 | Suspended | University of Missouri-Columbia | 65 | 2021-12-01 | 2025-12-19 |
| Insulin for Hyperglycemia in Stroke Trial Analog Insulin, Human insulin - Hyperglycemia, Stroke, Acute | Phase 4 | Completed | National Institute of Neurosciences and Hospital, Dhaka | 452 | 2021-04-05 | 2021-12-06 |
| Transdermal Insulin Response In Healthy Volunteers Human insulin - Pharmacodynamic Response to Small Doses of Insulin | Early Phase 1 | Completed | Transdermal Delivery Solutions Corp | 7 | 2021-03-12 | 2023-10-23 |
| Pupillography as Screening Tool for Brain Insulin Resistance human insulin, placebo, Pupillography - Obesity | Not applicable | Completed | University Hospital Tuebingen | 22 | 2018-07-03 | 2019-01-10 |
| HbA1c Variability in Type II Diabetes Metformin, Gliclazide, Sitagliptin - Diabetes Mellitus Type 2 | Not applicable | Active not recruiting | Weill Cornell Medical College in Qatar | 150 | 2016-11-01 | 2025-07-20 |
| Influence of Central Nervous Insulin Action on Insulin Sensitivity of Peripheral Organs in Lean Versus Overweight Humans human insulin - Insulin Resistance | Not applicable | Completed | University Hospital Tuebingen | 21 | 2015-01-01 | 2016-01-08 |
| A Study of LY2605541 (Insulin Peglispro) and Human Insulin Concentrations in Fat Tissue Insulin Peglispro, Human Insulin - Diabetes Mellitus, Type 1 | Phase 1 | Completed | Eli Lilly and Company | 24 | 2014-04-01 | 2019-03-06 |
| Insulin Sensitivity of the Human CNS System: fMRI Study With Intranasal Insulin Application Human Insulin, Placebo - Obesity, Diabetes | Not applicable | Completed | University Hospital Tuebingen | 48 | 2013-02-01 | 2015-12-03 |
| Molecular Regulation of Muscle Glucose Metabolism U100 Humulin, Exercise - Obesity, Type 2 Diabetes Mellitus | Phase 1 | Terminated | Mayo Clinic | 48 | 2012-04-01 | 2017-11-27 |
| Insulin Receptor Substrate 1 (IRS-1) Regulation in Insulin Resistance Human insulin - Type 2 Diabetes Mellitus | Phase 1 | Completed | Mayo Clinic | 14 | 2012-03-01 | 2013-06-05 |
| Effect of CSII and CGM on Progression of Late Diabetic Complications Insulin pump therapy (CSII) plus continuous glucose monitoring (CGM), Multiple daily insulin injections (MDI) - Type 1 Diabetes Mellitus | Phase 4 | Completed | Steen Andersen | 60 | 2011-12-01 | 2015-01-14 |
| Establishing Cardiovascular Biomarkers to Define Preferred Lantus® Use nph insulin, human insulin, Insulin Glargine - Insulin-requiring Type 2 Diabetes Mellitus | Phase 4 | Unknown | ikfe-CRO GmbH | 60 | 2011-10-01 | 2011-12-29 |
| Hepatic Insulin Sensitivity and Very Low Density Lipoprotein Triglyceride (VLDL-TG) Kinetics Glucose clamp - Obesity, Dyslipidemia | Not applicable | Completed | University of Aarhus | 24 | 2010-03-01 | 2011-06-17 |
| Basal Bolus Versus Human Insulin in Hospitalized Patients With Diabetes in Paraguay Basal Bolus (Glargine and Glulisine), Human Insulin - Hyperglycemia, Diabetes | Phase 4 | Completed | Universidad Nacional de Asunción | 134 | 2009-04-01 | 2014-10-30 |
| Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia Human insulin, Human Insulin - Hypoglycemia | Phase 4 | Completed | Gulhane School of Medicine | 51 | 2008-12-01 | 2009-11-13 |
| Observational Study to Investigate the Efficacy and Safety of Human Insulin or Insulin Analogue Treatments in Type 2 Diabetes Subjects human insulin, insulin analogue - Diabetes, Diabetes Mellitus, Type 2 | Completed | Novo Nordisk A/S | 4847 | 2008-12-01 | 2016-10-28 |
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Diabetes Mellitus (12) · Insulin Resistance (10) · Obesity (8) · Diabetes Mellitus, Type 1 (7) · Diabetes Mellitus, Type 2 (7) · Hyperglycemia (2) · Hypoglycemia (2) · Albuminuria (1) · Aneurysm (1) · Cognitive Dysfunction (1) · Diabetes, Gestational (1) · Dyslipidemias (1) · Hyperinsulinism (1) · Pemphigus (1) · Primary Dysautonomias (1)
Novo Nordisk A/S (8) · University Hospital Tuebingen (4) · University of Missouri-Columbia (3) · Mayo Clinic (2) · Transdermal Delivery Solutions Corp (2) · Alexandria University (1) · Eli Lilly and Company (1) · Gulhane School of Medicine (1) · Heidelberg University (1) · Hypoglycaemia Research Group (1) · National Institute of Neurosciences and Hospital, Dhaka (1) · Steen Andersen (1) · Universidad Nacional de Asunción (1) · University of Aarhus (1) · University of Colorado, Denver (1)
Germany (9) · United States (8) · Denmark (5) · Austria (2) · United Kingdom (2) · Argentina (1) · Australia (1) · Bangladesh (1) · Bulgaria (1) · Canada (1) · China (1) · Croatia (1) · Egypt (1) · Finland (1) · France (1)
Andreas Fritsche, MD (1) · Andreas Fritsche, Prof. Dr. (1) · Birger Thorsteinsson, MD, DMSci (1) · Carmen I Farid, MB BCh, MD (1) · Chandan A.S. Alam, MD (1) · Elvio Bueno, MD (1) · Ezio Bonifacio, PhD (1) · Georgeanna J Klingensmith, MD (1) · Jacqueline K Limberg, Ph.D. (1) · Katherine N Bachmann, MD (1) · Lawrence J. Mandarino, PhD (1)
PMID 12502678, PMID 17392539, PMID 17392541, PMID 17392542, PMID 17596485, PMID 17850471, PMID 17888133, PMID 17905178, PMID 18726086, PMID 19120432, PMID 19170163, PMID 19584889, PMID 20007944, PMID 20215476, PMID 23687948, PMID 25300286, PMID 25795413, PMID 25898052, PMID 26390102, PMID 28174292, PMID 31334795, PMID 32887707, PMID 33166419
R01DK047936 (1)