8 completed, 6 terminated, 3 unknown. 7 Not applicable, 3 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 4, Unknown 2, Terminated 1 |
| Phase 2 | 3 | Terminated 3 |
| Phase 1 | 1 | Terminated 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Gamma Knife Radiosurgery: new trials by email Literature Review of Gamma Knife Radiosurgery trials Research Report on Gamma Knife Radiosurgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Gamma Knife Radiosurgery on Tectal Plate Gliomas Gamma Knife Radiosurgery - Gamma Knife Radiosurgery, Tectal Plate Gliomas | Completed | Al-Azhar University | 60 | 2021-01-01 | 2025-06-11 | |
| Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection Microsurgical resection, Gamma Knife radiosurgery - Brain Metastases | Not applicable | Unknown | Medical University of Vienna | 100 | 2020-07-01 | 2024-01-05 |
| Long-Term Outcomes of Hypopituitarism Following Gamma Knife Radiosurgery for Pituitary Adenomas Gamma Knife Radiosurgery - Long Term, Hypopituitarism | Completed | Al-Azhar University | 137 | 2019-01-01 | 2025-06-11 | |
| Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma Gamma knife radiosurgery, Lanreotide 60Mg Solution for Injection - Acromegaly Due to Pituitary Adenoma | Phase 3 | Unknown | Samsung Medical Center | 90 | 2018-03-01 | 2018-03-01 |
| Evaluation of the Predictors of Clinical and Radiological Response to Gamma-Knife Radiosurgery in the Treatment of Intermediate Ventral Nucleus of the Thalamus (VIM) Thalamotomy Tremor. gamma knife radiosurgery - Severe Disabling Tremor | Completed | Assistance Publique Hopitaux De Marseille | 700 | 2017-10-25 | 2026-10-26 | |
| Stereotactic Radiosurgery With Nivolumab and Valproate in Patients With Recurrent Glioblastoma Stereotactic Radiosurgery, Nivolumab, Valproate - Glioblastoma | Phase 1 | Terminated | University of Virginia | 4 | 2016-05-24 | 2017-05-31 |
| Cognitive Outcome After SRS or WBRT in Patients With Multiple Brain Metastases (CAR-Study B) Gamma Knife radiosurgery, Whole Brain Radiation Therapy - Neoplasm Metastasis | Not applicable | Completed | Elisabeth-TweeSteden Ziekenhuis | 81 | 2016-02-01 | 2026-06-10 |
| Cognitive Outcome After Gamma Knife Radiosurgery in Patients With Brain Metastases (CAR-Study A) Gamma Knife radiosurgery - Neoplasm Metastases | Completed | Elisabeth-TweeSteden Ziekenhuis | 92 | 2015-10-01 | 2020-08-14 | |
| Late Effects of Radiosurgery on Acromegaly Study Gamma Knife radiosurgery - Acromegaly | Not applicable | Completed | Assistance Publique Hopitaux De Marseille | 66 | 2015-02-16 | 2023-04-18 |
| Vestibular Schwannoma - Radiosurgery or Expectation: V-REX. gamma knife radiosurgery - Vestibular Schwannoma | Not applicable | Completed | Haukeland University Hospital | 100 | 2014-10-01 | 2025-04-02 |
| Gamma Knife Radiosurgery for Treatment of Essential Tremor Gamma Knife Radiosurgery - Essential Tremor | Not applicable | Unknown | Swedish Medical Center | 183 | 2014-09-01 | 2023-01-23 |
| Neurocognition After Gamma Knife Radiosurgery for Multiple Brian Metastases Gamma knife radiosurgery - Neoplasm Metastases | Terminated | CancerCare Manitoba | 3 | 2014-04-01 | 2016-05-30 | |
| A Pilot/Phase II Study of Gamma Knife Radiosurgery for Brain Metastases Using 3Tesla MRI and Rational Dose Selection Gamma Knife Radiosurgery - Melanoma, Renal Cell Carcinoma | Not applicable | Terminated | Yale University | 39 | 2013-11-01 | 2019-07-01 |
| Dabrafenib and Trametinib With Radiosurgery in Melanoma Brain Mets Dabrafenib, Gamma Knife Radiosurgery, Trametinib - BRAFV600E Melanoma Patients | Phase 2 | Terminated | University of California, San Francisco | 2 | 2013-04-01 | 2018-01-23 |
| Evaluation of the Safety and Efficacy of Bilateral Subthalamic Nucleus (SNT) Radiosurgery in Idiopathic Severe Parkinson's Disease Fulfilling Inclusion Criteria for STN Deep Brain Stimulation and Presenting With a Contraindication to Intracerebral Electrode Implantation. Gamma Knife radiosurgery - Parkinson's Disease, With Inclusion Criteria for STN Deep Brain Stimulation | Not applicable | Completed | Assistance Publique Hopitaux De Marseille | 14 | 2011-02-04 | 2023-04-14 |
| Study of Gamma-Knife Radiosurgery Using Magnetic Resonance Imaging (MRI) Spectroscopy for Recurrent Glioma Gamma Knife Radiosurgery - Glioblastoma | Phase 2 | Terminated | University of California, San Francisco | 1 | 2009-12-01 | 2013-05-06 |
| Radiosurgical Treatment for Obsessive-compulsive Disorder ventral capsular/ventral striatal gamma capsulotomy - Obsessive-compulsive Disorder | Phase 2 | Terminated | University of Sao Paulo General Hospital | 16 | 2003-07-01 | 2012-10-12 |
Brain Neoplasms (6) · Neoplasm Metastasis (3) · Acromegaly (2) · Anxiety Disorders (2) · Depression (2) · Fatigue (2) · Glioblastoma (2) · Melanoma (2) · Pituitary Neoplasms (2) · Breast Neoplasms (1) · Carcinoma, Renal Cell (1) · Central Nervous System Diseases (1) · Cognition Disorders (1) · Colorectal Neoplasms (1) · Essential Tremor (1)
Assistance Publique Hopitaux De Marseille (3) · Al-Azhar University (2) · Elisabeth-TweeSteden Ziekenhuis (2) · University of California, San Francisco (2) · CancerCare Manitoba (1) · Haukeland University Hospital (1) · Medical University of Vienna (1) · Samsung Medical Center (1) · Swedish Medical Center (1) · University of Sao Paulo General Hospital (1) · University of Virginia (1) · Yale University (1)
United States (5) · France (3) · Egypt (2) · Netherlands (2) · Austria (1) · Brazil (1) · Canada (1) · Norway (1) · South Korea (1)
Patrick EJ Hanssens, MD (2) · Alain Algazi, MD (1) · Antonio C Lopes, MD, PhD (1) · Benjamin Purow, MD (1) · Christopher Loiselle, MD (1) · Harvey Quon, MD (1) · James B Yu, MD (1) · Jennifer Clarke, MD, MPH (1) · Morten Lund-Johansen, MD PhD (1)
PMID 25054836, PMID 25645373, PMID 27223498, PMID 29466961, PMID 31342318, PMID 31552588, PMID 33025282, PMID 33737417, PMID 37249646, PMID 37526718, PMID 39168114