11 completed, 4 terminated, 1 withdrawn. 11 Phase 2, 7 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 8, Terminated 3 |
| Phase 1 | 7 | Completed 4, Terminated 3 |
| Phase 3 | 2 | Terminated 1, Withdrawn 1 |
Follow fosbretabulin: new trials by email Literature Review of fosbretabulin trials Research Report on fosbretabulin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fosbretabulin With Everolimus in Neuroendocrine Tumors With Progression everolimus, fosbretabulin - Neuroendocrine Tumors, Everolimus | Phase 1 | Terminated | Lowell Anthony, MD | 17 | 2017-03-06 | 2019-08-08 |
| Fosbretabulin or Placebo in Combination With Carboplatin/Paclitaxel in Anaplastic Thyroid Cancer Fosbretabulin + paclitaxel + carboplatin, Placebo + paclitaxel + carboplatin - Anaplastic Thyroid Cancer | Phase 3 | Withdrawn | Mateon Therapeutics | 2015-03-01 | 2014-05-01 | |
| Rollover Protocol for Subjects Who Have Responded on Study 4218s - A Phase 2 Study fosbretabulin - Neuroendocrine Tumors | Phase 2 | Completed | Mateon Therapeutics | 7 | 2014-12-01 | 2018-04-17 |
| A Ph 2 Study of Fosbretabulin in Subjects w Pancreatic or Gastrointestinal Neuroendocrine Tumors w Elevated Biomarkers fosbretabulin tromethamine - Neuroendocrine Tumors | Phase 2 | Completed | Mateon Therapeutics | 18 | 2014-09-01 | 2017-12-05 |
| PAZOFOS: Phase Ib and Phase II Trial of Pazopanib +/- Fosbretabulin in Advanced Recurrent Ovarian Cancer Pazopanib, Fosbretabulin - Ovarian Neoplasms, Neoplasms, Ovarian | Phase 1 / Phase 2 | Terminated | The Christie NHS Foundation Trust | 21 | 2014-09-01 | 2021-05-17 |
| Study Evaluating the Safety and Response of Fosbretabulin in Asian Patients With Polypoidal Choroidal Vasculopathy (PCV) fosbretabulin, Saline - Polypoidal Choroidal Vasculopathy | Phase 2 | Completed | Mateon Therapeutics | 20 | 2009-07-01 | 2011-11-01 |
| A Safety and Efficacy Study of Carboplatin, Paclitaxel, Bevacizumab and CA4P in Non-Small Cell Lung Cancer Fosbretabulin, Carboplatin, Paclitaxel - Tumors | Phase 2 | Completed | Mateon Therapeutics | 63 | 2008-03-01 | 2015-02-09 |
| Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid Cancer CA4P, paclitaxel, carboplatin - Anaplastic Thyroid Cancer | Phase 2 / Phase 3 | Terminated | Mateon Therapeutics | 80 | 2007-08-01 | 2014-06-09 |
| Safety Study of Increasing Doses of Combretastatin in Combination With Bevacizumab (Avastin) in Patients With Advanced Solid Tumors Combretastatin A4 Phosphate (CA4P), Bevacizumab (Avastin) - Tumors | Phase 1 | Completed | Mateon Therapeutics | 20 | 2006-09-01 | 2011-10-31 |
| Safety and Efficacy Study of Combretastatin A4 Phosphate to Treat Patients With Choroidal Neovascularization Secondary to Pathologic Myopia Combretastatin A-4 Phosphate - Choroidal Neovascularization, Myopia, Degenerative | Phase 2 | Completed | Mateon Therapeutics | 23 | 2005-03-01 | 2011-11-01 |
| Safety and Effectiveness of Combretastatin A-4 Phosphate Combined With Chemotherapy in Advanced Solid Tumors Combretastatin A-4 Phosphate + Paclitaxel + Carboplatin - Cancer, Tumor | Phase 2 | Completed | Mateon Therapeutics | 13 | 2005-03-01 | 2011-11-01 |
| Induction Chemotherapy Using Doxorubicin and Cisplatin Followed by Combretastatin A4 Phosphate and Radiation Therapy in Treating Patients With Newly Diagnosed Regionally Advanced Anaplastic Thyroid Cancer filgrastim, pegfilgrastim, cisplatin - Head and Neck Cancer | Phase 1 / Phase 2 | Terminated | Case Comprehensive Cancer Center | 4 | 2003-11-01 | 2010-06-11 |
| Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration Combretastatin A-4 phosphate, Combretastatin A-4 Phosphate - Combretastatin A4 Phosphate, Age-related Macular Degeneration | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 8 | 2003-05-01 | 2017-12-06 |
| Combretastatin A4 Phosphate in Treating Patients With Advanced Anaplastic Thyroid Cancer fosbretabulin disodium - Head and Neck Cancer | Phase 2 | Completed | Case Comprehensive Cancer Center | 26 | 2003-02-01 | 2010-06-11 |
| Combretastatin A4 Phosphate in Treating Patients With Advanced Solid Tumors fosbretabulin disodium - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | Case Comprehensive Cancer Center | 25 | 1998-09-01 | 2014-01-07 |
| Chemotherapy in Treating Patients With Solid Tumors fosbretabulin disodium - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | University of Glasgow | 35 | 1998-07-01 | 2013-12-19 |
Thyroid Carcinoma, Anaplastic (4) · Head and Neck Neoplasms (3) · Neoplasms (3) · Neuroendocrine Tumors (3) · Thyroid Neoplasms (3) · Choroidal Neovascularization (2) · Carcinoid Tumor (1) · Carcinoma, Non-Small-Cell Lung (1) · Lung Neoplasms (1) · Macular Degeneration (1) · Myopia, Degenerative (1) · Neoplasm Metastasis (1) · Neuroectodermal Tumors, Primitive (1) · Ovarian Neoplasms (1) · Polypoidal Choroidal Vasculopathy (1)
Mateon Therapeutics (9) · Case Comprehensive Cancer Center (3) · Johns Hopkins University (1) · Lowell Anthony, MD (1) · The Christie NHS Foundation Trust (1) · University of Glasgow (1)
United States (11) · United Kingdom (4) · Belarus (1) · Bulgaria (1) · Egypt (1) · Hong Kong (1) · India (1) · Israel (1) · Italy (1) · Poland (1) · Romania (1) · Russia (1) · Singapore (1) · South Korea (1) · Taiwan (1)
Panayiotis Savvides, MD (2) · Gordon J.S. Rustin, MD (1) · Gordon Jayson (1) · Gordon Rustin (1) · Hillori Connors, MS (1) · Jai Balkissoon, MD, FACS (1) · Julie A Sosa, MD (1) · Julie A. Sosa, MD, FACS (1) · Lisa Licitra, MD (1) · Lowell Anthony, MD (1) · Marcia Brose, MD, PhD (1) · Paul Nathan, MD (1) · Peter Harris, MD (1) · Quan D Nguyen, MD, MSc (1) · Scot C. Remick, MD (1)
PMID 37816266, PMID 12807934, PMID 19265494, PMID 23316779, PMID 31932108
P30CA043703 (2)