13 completed, 10 unknown. 11 Not applicable, 3 Phase 4, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 6, Unknown 5 |
| Phase 4 | 3 | Unknown 3 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow FFR: new trials by email Literature Review of FFR trials Research Report on FFR
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate Direct Wire Pacing (DWP) for Measuring Fractional Flow Reserve (FFR) FFR DWP, FFR - Coronary Artery Stenosis, Fractional Flow Reserve | Not applicable | Completed | Centre Recherche Cardio Vasculaire Alpes | 150 | 2021-06-17 | 2023-12-15 |
| The Flash FFR Ⅱ Study caFFR, FFR - Coronary Artery Disease, Coronary Stenosis | Not applicable | Unknown | Peking University First Hospital | 2132 | 2021-01-12 | 2023-03-21 |
| Diagnostic Accuracy of CFD-Based Fractional Flow Reserve Derived From Coronary Angiography FFR - Coronary Artery Disease | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 318 | 2020-11-04 | 2023-03-08 | |
| Diagnostic Accuracy of CCTA-derived Versus AngiogRaphy-dErived QuantitativE Flow Ratio (CAREER) Study CT-QFR, QFR, FFR - Coronary Stenosis, Hemodynamics | Unknown | Fudan University | 216 | 2020-10-01 | 2022-01-25 | |
| FUnctional diagnoSIs of corONary Stenosis (FUSION) ICA (Invasive Coronary Angiography), OCT, FFR - Coronary Artery Disease, Coronary Stenosis | Completed | Abbott Medical Devices | 312 | 2020-06-26 | 2025-02-21 | |
| RFR and FFR for the the Prediction of Post-PCI Results RFR, FFR - Coronary Artery Disease | Phase 4 | Unknown | Johannes Gutenberg University Mainz | 100 | 2020-05-10 | 2023-09-28 |
| Diagnostic Performance of Fractional Flow Reserve Derived From Coronary CT Angiography FFR - Coronary Artery Disease | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 339 | 2020-04-15 | 2023-03-08 | |
| Fractional FLOw Reserve In Cardiovascular DiseAses Fractional flow reserve, Angiography-only - Coronary Artery Disease, Acute Coronary Syndrome | Completed | LinkCare GmbH | 64045 | 2019-12-01 | 2020-10-22 | |
| Clinical Study on the Correlation Between IMR（Index of Microcirculation Resistance） and FFR（Fractional Flow Reserve） FFR - Myocardial Ischemia | Not applicable | Unknown | The People's Hospital of Liaoning Province | 60 | 2019-09-01 | 2020-01-13 |
| The Drift-Reduction for Improved FFR Using Fiberoptic Technology (DRIFT) Study OpSens Medical OptoWire, FFR - Left Anterior Descending Coronary Artery Stenosis | Not applicable | Completed | Columbia University | 60 | 2018-06-19 | 2024-06-11 |
| CMR or Angiography for FFR-guided Revascularisation FFR - STEMI | Not applicable | Unknown | Karolinska Institutet | 100 | 2018-01-26 | 2022-06-08 |
| Integrated Coronary Multicenter Imaging Registry OCT (Optical Coherence Tomography), Coronary CTA, FFR - Coronary Artery Disease | Unknown | Yonsei University | 180 | 2017-10-10 | 2020-10-19 | |
| One-Dimensional Mathematical Model-Based Automated Assessment of Fractional Flow Reserve FFR - Coronary Artery Disease | Not applicable | Completed | I.M. Sechenov First Moscow State Medical University | 31 | 2017-04-05 | 2020-05-18 |
| Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease Coronary stenting, intracoronary ECG recording, Coronary Flow reserve - Myocardial Ischemia | Phase 2 / Phase 3 | Completed | Italo Porto | 58 | 2016-06-01 | 2020-11-16 |
| Cocktail Injection Improves Outcomes of FFR Guided PCI cocktail, FFR, QCA guided group - Acute Coronary Syndromes | Phase 4 | Unknown | Xijing Hospital | 500 | 2015-10-01 | 2015-10-30 |
| Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome iFR, FFR - Angina Pectoris, Acute Myocardial Infarction | Not applicable | Completed | Uppsala University | 2037 | 2014-05-01 | 2017-01-12 |
| Trial Evaluating New Strategy in the Functional Assessment of 3-vessel Disease Using SYNTAXII Score in Patients With PCI Coronary stent, Multi Slice Computed Tomography, instantaneous wave-free ratio - Heart Diseases, Cardiovascular Diseases | Completed | ECRI bv | 454 | 2014-02-06 | 2022-07-21 | |
| Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation iFR, FFR - Coronary Artery Disease | Not applicable | Unknown | Imperial College London | 2500 | 2014-01-01 | 2019-08-14 |
| FAMOUS-NSTEMI MRI Sub-Study Fractional flow reserve, Magnetic resonance imaging - NonST Elevation Myocardial Infarction | Completed | NHS National Waiting Times Centre Board | 106 | 2011-10-01 | 2024-10-29 | |
| Fractional Flow Reserve Versus Angiographically Guided Management to Optimise Outcomes in Unstable Coronary Syndromes Fractional flow reserve - NonST Elevation Myocardial Infarction, Myocardial Infarction | Phase 4 | Unknown | NHS National Waiting Times Centre Board | 350 | 2011-10-01 | 2017-06-14 |
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Coronary Artery Disease (13) · Coronary Stenosis (5) · Acute Coronary Syndrome (2) · Angina Pectoris (2) · Myocardial Ischemia (2) · ST Elevation Myocardial Infarction (2) · Angina, Stable (1) · Angina, Unstable (1) · Cardiovascular Diseases (1) · Disease (1) · Heart Diseases (1) · Myocardial Infarction (1) · Non-ST Elevated Myocardial Infarction (1) · photopsia (1)
NHS National Waiting Times Centre Board (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Abbott Medical Devices (1) · Centre Recherche Cardio Vasculaire Alpes (1) · Columbia University (1) · Copenhagen University Hospital, Rigshospitalet (1) · ECRI bv (1) · Fudan University (1) · HeartFlow, Inc. (1) · I.M. Sechenov First Moscow State Medical University (1) · Imperial College London (1) · Italo Porto (1) · Johannes Gutenberg University Mainz (1) · Karolinska Institutet (1) · LinkCare GmbH (1)
China (6) · United Kingdom (4) · United States (4) · Germany (3) · Denmark (2) · Italy (2) · Netherlands (2) · South Korea (2) · Spain (2) · Sweden (2) · Australia (1) · Belgium (1) · Egypt (1) · Finland (1) · France (1)
Javier Escaned, MD (2) · Adrian Banning, MD (1) · Allen Jeremias, MD (1) · Andrew Briggs, PhD (1) · Benjamin Faurie (1) · Colin Berry, MB ChB BSc FRCP FACC (1) · Colin Berry, MD PhD (1) · Daria Gognieva, MD (1) · Dongdong Sun, M.D.,Ph.D. (1) · Ernest Spitzer, MD (1) · Ian Ford, PhD (1) · James K Min, MD, FACC (1) · Jung-Sun Kim, PhD (1)
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