40 completed, 20 active not recruiting, 20 recruiting, 15 unknown. 44 Phase 2, 23 Phase 1, 22 Phase 3, 21 Not applicable, 2 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of Pembrolizumab With Chemotherapy or Chemoradiotherapy in Participants From India With Different Types of Cancer (MK-3475-G44/KEYNOTE-G44) Pembrolizumab, Cisplatin, 5-Fluorouracil - Neoplasm Malignant, Gastric Neoplasms | Phase 4 | Not yet recruiting | Merck Sharp & Dohme LLC | 150 | 2026-11-06 | 2026-09-03 |
| Overcoming Immunotherapy Resistance in Hepatocellular Carcinoma External beam radiotherapy, transarterial radioembolization - Hepatocellular Carcinoma Non-Resectable | Not applicable | Not yet recruiting | Radboud University Medical Center | 16 | 2026-10-01 | 2026-10-26 |
| Adding Spatially Fractionated Radiation Therapy to Standard Palliative Radiation for Improving Disease-Related Symptoms in Patients With Unresectable Solid Tumors Electronic Health Record Review, External Beam Radiation Therapy, Questionnaire Administration - Metastatic Malignant Solid Neoplasm, Unresectable Malignant Solid Neoplasm | Not applicable | Recruiting | Mayo Clinic | 100 | 2026-09-23 | 2026-10-26 |
| Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer Biospecimen Collection, Chemotherapy, Decitabine - Human Papillomavirus-Negative Neck Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | Mayo Clinic | 32 | 2026-01-23 | 2026-07-15 |
| PD-1 + FOLFOXIRI vs CAPOX as Total Neoadjuvant Therapy for pMMR Low Rectal Cancer Serplulimab, FOLFOXIRI chemotherapy, CAPOX chemotherapy - Locally Advanced Low Rectal Adenocarcinoma, pMMR (Microsatellite Stable Rectal Cancer) | Phase 3 | Not yet recruiting | Sun Yat-sen University | 382 | 2025-12-29 | 2025-12-11 |
| Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial Biospecimen Collection, Chemotherapy, Computed Tomography - Ewing Sarcoma, Round Cell Sarcoma With EWSR1-non-ETS Fusion | Not applicable | Recruiting | Mayo Clinic | 170 | 2025-12-05 | 2026-10-06 |
| Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer Biospecimen Collection, Brachytherapy, Carboplatin - Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 336 | 2025-11-05 | 2026-10-26 |
| External Beam Radiation Therapy in Combination With Talquetamab for the Treatment of Multiple Myeloma Patients With Extramedullary Disease Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Extramedullary Disease in Multiple Myeloma, Multiple Myeloma | Phase 1 / Phase 2 | Suspended | City of Hope Medical Center | 20 | 2025-08-29 | 2026-10-07 |
| External Beam Radiation Therapy and Brachytherapy With Chemotherapy and Immunotherapy for the Treatment of Stage IVB Cervical Cancer Bevacizumab, Biospecimen Collection, Brachytherapy - Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma | Phase 1 / Phase 2 | Recruiting | Jonsson Comprehensive Cancer Center | 35 | 2025-07-29 | 2026-08-12 |
| Survival Efficacy of Combined Radiotherapy and Immunotherapy in Patients With Metastatic Non-small Cell Lung Carcinoma Immunotherapy, Radiotherapy - Non Small Cell Lung Cancer Metastatic | Completed | Hopitaux Prives de Metz, Groupe UNEOS | 350 | 2024-10-14 | 2025-08-08 | |
| PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes, Biopsy, Biospecimen Collection - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 | Recruiting | City of Hope Medical Center | 21 | 2024-10-09 | 2026-08-21 |
| Hypofractionated External Beam Radiotherapy With Adaptive Planning for Endometrial and Cervical Cancers External beam Radiotherapy - Endometrial Cancer, Cervical Cancer | Not applicable | Recruiting | Jonsson Comprehensive Cancer Center | 60 | 2024-07-24 | 2026-08-20 |
| MR Guided Focused Ultrasound vs Radiotherapy for Palliative Pain Tx in Bone Metastases MR- High intensity focused ultrasound, External beam radiotherapy - Bone Metastases | Not applicable | Withdrawn | Stanford University | 2024-06-01 | 2024-10-01 | |
| Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer Biospecimen Collection, Carboplatin, Cisplatin - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 45 | 2024-03-21 | 2026-03-24 |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer Biospecimen Collection, Bone Scan, Computed Tomography - Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 1500 | 2023-12-14 | 2026-10-23 |
| Radioligand Therapy After PSMA PET Guided External Beam Radiotherapy for Treating Post-Prostatectomy Patients With Biochemically Recurrent Prostate Cancer Biospecimen Collection, Computed Tomography, External Beam Radiation Therapy - Biochemically Recurrent Prostate Carcinoma, Prostate Adenocarcinoma | Phase 1 | Active not recruiting | Emory University | 6 | 2023-11-29 | 2025-12-09 |
| Relugolix in Combination With Radiation Therapy for Treating Patients With High Risk Prostate Cancer Biospecimen Collection, Bone Scan, Brachytherapy - Stage IIC Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8 | Phase 2 | Not yet recruiting | University of Kansas Medical Center | 90 | 2023-11-20 | 2023-11-13 |
| 5-Day Preoperative Radiation for Soft Tissue Sarcoma External Beam Radiotherapy - Soft Tissue Sarcoma | Phase 2 | Recruiting | Stanford University | 75 | 2023-10-06 | 2026-06-10 |
| MCT for the Harvard/UCSF ROBIN Center External beam radiotherapy, 131I-Metaiodobenzylguanidine (MIBG) - Glioma, Childhood Brainstem, Neuroblastoma | Not applicable | Recruiting | Brigham and Women's Hospital | 47 | 2023-09-19 | 2026-10-01 |
| Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy, Computed Tomography - Recurrent Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma | Early Phase 1 | Recruiting | City of Hope Medical Center | 9 | 2023-07-20 | 2026-02-04 |
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Prostatic Neoplasms (20) · Uterine Cervical Neoplasms (13) · Neoplasms (7) · Neuroblastoma (6) · Sarcoma (6) · Neoplasm Metastasis (5) · Adenocarcinoma Of Esophagus (4) · Ganglioneuroblastoma (4) · Rectal Neoplasms (4) · Breast Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (3) · Endometrial Neoplasms (3) · Multiple Myeloma (3) · Sarcoma, Ewing (3) · Squamous Cell Carcinoma of Head and Neck (3)
National Cancer Institute (NCI) (13) · M.D. Anderson Cancer Center (8) · City of Hope Medical Center (5) · Mayo Clinic (5) · Children's Oncology Group (4) · Jonsson Comprehensive Cancer Center (3) · NRG Oncology (3) · Stanford University (3) · Sun Yat-sen University (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · All India Institute of Medical Sciences (2) · GOG Foundation (2) · Ohio State University Comprehensive Cancer Center (2) · University Health Network, Toronto (2) · University of Washington (2)
United States (67) · Canada (17) · China (7) · Puerto Rico (7) · Australia (6) · Netherlands (6) · United Kingdom (6) · Germany (4) · India (4) · New Zealand (4) · Switzerland (4) · France (3) · Italy (3) · Austria (2) · Egypt (2)
Jyoti S Mayadev (2) · Sam Ngan (2) · Steven G DuBois (2) · Adam L. Holtzman, MD (1) · Adam P Dicker, MD, PhD (1) · Adi Levy, MD (1) · Al Benson (1) · Albert Chang (1) · Andreas Schuck, MD PhD (1) · Anne-Sophie van den Heerik, MD (1) · Anthony V D'Amico, M.D. Ph.D. (1) · Anusha Kalbasi, MD (1) · Ariane Guignard, Resident (1) · Benjamin D Smith (1)
PMID 34028986, PMID 38421243, PMID 14652672, PMID 14668957, PMID 15315996, PMID 16400382, PMID 18212313, PMID 18325680, PMID 18455325, PMID 19211071, PMID 19322503, PMID 19395184, PMID 19395186, PMID 19574206, PMID 19858385, PMID 19864082, PMID 19957321, PMID 20207506, PMID 20505894, PMID 21316126, PMID 21444871, PMID 21840137, PMID 22307061, PMID 22498212, PMID 23603369, PMID 23798006, PMID 24373638, PMID 24693436, PMID 24864213, PMID 25581596, PMID 25680598, PMID 26074402, PMID 26194683, PMID 26247543, PMID 26939629, PMID 27514314, PMID 27601545, PMID 27789196, PMID 28097317, PMID 28185875, PMID 28581396, PMID 28686124, PMID 29029833, PMID 29868473, PMID 29914796, PMID 30027292, PMID 30078506, PMID 30579270, PMID 31377161, PMID 31454045
U10CA180868 (10), U10CA180886 (6), P30CA033572 (4), U10CA098543 (4), U10CA027469 (3), P30CA015704 (2), U10CA021661 (2), 2015 (1), P30CA012197 (1), P30CA138292 (1), P30CA168524 (1), R01CA274985 (1), R01CA294704 (1), R21CA153587 (1), U10CA021115 (1)