5 completed, 2 recruiting, 2 unknown, 1 active not recruiting. 4 Phase 4, 2 Early Phase 1, 2 Not applicable, 2 Phase 2, 1 Phase 1.
Follow Estradiol Patch: new trials by email Literature Review of Estradiol Patch trials Research Report on Estradiol Patch
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cyclic vs. Constant Estradiol: Regimens' Effects on Brain Health Cyclic Estradiol, Continuous Estradiol - Menopause, Healthy Adult | Phase 4 | Recruiting | University of Colorado, Denver | 40 | 2026-07-15 | 2026-09-21 |
| Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes Testosterone Enanthate, Testosterone Cypionate, Testosterone Propionate - Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes | Not applicable | Enrolling by invitation | Enhanced Emirates Limited | 60 | 2026-03-12 | 2026-05-06 |
| Role of Menopause in Thermoregulation Elagolix Oral Tablet, Estradiol patch, cellulose placebo - Menopause, Aging | Phase 4 | Recruiting | Penn State University | 24 | 2025-03-01 | 2026-10-02 |
| Rhythmic Estradiol and Bone Health Estradiol patch, Progesterone - Osteoporosis Risk, Menopause | Phase 4 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 48 | 2023-07-19 | 2026-10-16 |
| Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion Micronized progesterone, Placebo, Flutamide - PCOS, Polycystic Ovary Syndrome | Early Phase 1 | Unknown | University of Virginia | 10 | 2022-10-26 | 2023-11-02 |
| Estrogen Administration for the Treatment of NASH in Postmenopausal Women Estradiol patch, Placebo - NASH - Nonalcoholic Steatohepatitis | Phase 3 | Active not recruiting | Massachusetts General Hospital | 50 | 2021-12-02 | 2026-08-07 |
| Estrogen Patch for COVID-19 Symptoms Estradiol patch - COVID | Phase 2 | Terminated | Sharon Nachman | 2 | 2020-04-20 | 2021-11-26 |
| Neuroendocrine Risk for PTSD in Women Estradiol patch, Placebo patch - PTSD, Trauma | Early Phase 1 | Completed | Emory University | 127 | 2019-11-11 | 2026-07-22 |
| The Interaction Between Diabetes and Estradiol on Human Brain Metabolism in Postmenopausal Women Estradiol patch - Diabetes Type 2, Dementia | Phase 1 | Completed | Wake Forest University Health Sciences | 12 | 2019-05-13 | 2022-09-27 |
| Oophorectomy, Estrogen Therapy and Cardiovascular Disease Risk in Young Women Estradiol 100 Micrograms Patch, Estradiol Patch - Cardiovascular Risk Reduction | Phase 2 | Completed | Mayo Clinic | 35 | 2019-03-15 | 2024-10-23 |
| Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction Estradiol patch, Cetrotide, Fasting - Heart Diseases, Left Ventricular Dysfunction | Phase 4 | Unknown | The University of Texas at Arlington | 100 | 2018-09-13 | 2024-02-20 |
| KEEPS Mammographic Density And Breast Health Ancillary Study CEE pill, Estradiol patch, Active Progesterone - Mammographic Density, Abnormal Mammogram | Not applicable | Completed | Brigham and Women's Hospital | 517 | 2005-09-01 | 2017-03-08 |
Cardiovascular Diseases (1) · Dementia (1) · Diabetes Mellitus, Type 2 (1) · Fasting (1) · Heart Diseases (1) · Heat Stress Disorders (1) · Non-alcoholic Fatty Liver Disease (1) · Polycystic Ovary Syndrome (1) · Stress Disorders, Post-Traumatic (1) · Stress Disorders, Traumatic (1) · Ventricular Dysfunction, Left (1) · Wounds and Injuries (1)
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Brigham and Women's Hospital (1) · Emory University (1) · Enhanced Emirates Limited (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Penn State University (1) · Sharon Nachman (1) · The University of Texas at Arlington (1) · University of Colorado, Denver (1) · University of Virginia (1) · Wake Forest University Health Sciences (1)
United States (10) · Netherlands (1) · United Arab Emirates (1)
Christina Hugenschmidt, PhD (1) · Christopher M McCartney, MD (1) · Ekta Kapoor, MBBS (1) · Jennifer Stevens, PhD (1) · Karen K. Miller, MD (1) · Kathy Rexrode, MD (1) · Neill Epperson, MD (1) · Peter M Bisschop (1) · Sharon Nachman, MD (1) · W. Larry Kenney, Ph.D. (1)
R01CA136918 (1), R01DK126955 (1), R01HD102060 (1), R01MH117009 (1), R21AG054955 (1)