12 terminated. 12 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 12 | Terminated 12 |
Follow Epinephrine: new trials by email Literature Review of Epinephrine trials Research Report on Epinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The PAIN (Pelvic Area Injection for Numbness) Study Bupivacaine, Epinephrine, Sham normal saline arm - Vaginal Laceration During Delivery | Phase 4 | Terminated | Montefiore Medical Center | 3 | 2025-04-08 | 2026-05-27 |
| Combination of Buffered Anesthetic to Treat Mandibular Molars Sodium bicarbonate, Lidocaine w/ epi, Articaine w/ epi - Symptomatic Irreversible Pulpitis | Phase 4 | Terminated | Indiana University | 40 | 2023-12-05 | 2025-05-13 |
| Comparing Local Anesthesia With and Without iPACK Block Real iPACK block (20 mL of 0.25% bupivacaine, 2.5mcg/mL epinephrine, and 50mcg/mL preservative-free dexamethasone), Sham iPACK block with 20ml normal saline - Osteo Arthritis Knee, Analgesia | Phase 4 | Terminated | University of Calgary | 10 | 2022-10-30 | 2026-06-01 |
| iPACK Block With Dexamethasone For Total Knee Replacement ropivacaine 0.25% with epinephrine and 6mg dexamethasone, Saline - Knee Osteoarthritis, Acute Pain | Phase 4 | Terminated | University of California, San Diego | 14 | 2021-06-07 | 2023-11-07 |
| Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin - Opioid Pain Medication | Phase 4 | Terminated | NYU Langone Health | 46 | 2021-03-24 | 2024-06-26 |
| Paravertebral Nerve Blocks in Neonates Paravertebral Nerve Block, Standard of Care Anesthesia - Congenital Heart Disease | Phase 4 | Terminated | Emory University | 16 | 2018-07-18 | 2025-03-24 |
| Comparison of Epinephrine and Phenylephrine/Ketorolac With Regards to Pupil Size Phenylephrine-ketorolac, Epinephrine - Cataract | Phase 4 | Terminated | Milton S. Hershey Medical Center | 59 | 2016-09-01 | 2020-01-31 |
| Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty Ropivacaine, Ketorolac, Clonidine - Osteoarthritis, Knee | Phase 4 | Terminated | Virginia Commonwealth University | 64 | 2015-10-01 | 2022-03-04 |
| Fractional Laser Assisted Topical Anesthesia AFXL, AHES, EMLA cream - Cicatrix | Phase 4 | Terminated | Netherlands Institute for Pigment Disorders | 3 | 2015-06-01 | 2019-03-13 |
| Efficacy of Rectal Infiltration of Exparel for Analgesic Benefit Following Hemorrhoidectomy Exparel, Bupivacaine HCl with Epinephrine, Normal Saline - Hemorrhoid | Phase 4 | Terminated | St. Luke's-Roosevelt Hospital Center | 11 | 2014-04-01 | 2018-12-04 |
| Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage Lidocaine, Vapocoolant - Abscess | Phase 4 | Terminated | Albert Einstein Healthcare Network | 21 | 2012-08-01 | 2020-03-19 |
| Postoperative Analgesia After Total Knee Arthroplasty Ropivacaine, Ketorolac, adrenaline, Ropivacaine Ketorolac - Arthroplasty, Replacement, Knee | Phase 4 | Terminated | University of Aarhus | 80 | 2007-01-01 | 2008-05-07 |
Pain, Postoperative (3) · Osteoarthritis, Knee (2) · Abscess (1) · Acute Pain (1) · Agnosia (1) · Cataract (1) · Cicatrix (1) · Furunculosis (1) · Heart Defects, Congenital (1) · Hemorrhoids (1)
Albert Einstein Healthcare Network (1) · Emory University (1) · Indiana University (1) · Milton S. Hershey Medical Center (1) · Montefiore Medical Center (1) · NYU Langone Health (1) · Netherlands Institute for Pigment Disorders (1) · St. Luke's-Roosevelt Hospital Center (1) · University of Aarhus (1) · University of Calgary (1) · University of California, San Diego (1) · Virginia Commonwealth University (1)
United States (8) · Canada (1) · Denmark (1) · Netherlands (1)
Albert Wolkerstorfer, MD, PhD (1) · Ali Shariat, MD (1) · Birgitte V Christensen, M.D. (1) · David Chiu, MD (1) · Engy Said, MD (1) · Fatima Estrada, MD, FACOG (1) · Gregory Golladay, MD (1) · Joseph D'Orazio, MD (1) · Justin B Long, MD (1) · Kenneth Spolnik, DDS (1) · Menno A. De Rie, MD, PhD (1) · Rajrishi Sharma, MD (1)
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