9 completed, 2 terminated, 2 unknown, 1 no longer available. 5 Phase 1, 3 Not applicable, 2 Early Phase 1, 2 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 4, Terminated 1 |
| Not applicable | 3 | Completed 2, Terminated 1 |
| Early Phase 1 | 2 | Completed 1, Recruiting 1 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Dichloroacetate: new trials by email Literature Review of Dichloroacetate trials Research Report on Dichloroacetate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Regulation of Brain Glucose Metabolism in Type 1 Diabetes Dichloroacetate - Diabetes Mellitus, Type 1, Hypoglycemia Unawareness | Early Phase 1 | Recruiting | Yale University | 16 | 2025-05-13 | 2026-06-09 |
| A Clinical Trial to Evaluate Dichloroacetate (DCA) as a Treatment for Endometriosis-associated Pain Dichloroacetate - Endometriosis | Not applicable | Completed | University of Edinburgh | 30 | 2019-11-19 | 2024-06-13 |
| Development of Agents to Diminish the Risk of Hypoglycemia-induced Brain Injury in Type 1 Diabetes Dichloroacetate, Placebo oral capsule - Hyperglycaemia (Diabetic) | Early Phase 1 | Completed | Yale University | 21 | 2017-11-30 | 2021-01-22 |
| 13C-Pyruvate Breath Test 13C-Pyruvate 13C-lactate and dichloroacetate - Healthy | Phase 1 | Completed | University of Florida | 5 | 2013-03-01 | 2015-12-02 |
| Role of Preoperative Carbohydrates Drinks, Dichloroacetate and Exercise on Postoperative Muscle Insulin Resistance Dichloroacetate, Carbohydrate drinks, Moderate intensity exercise - Insulin Resistance | Phase 4 | Unknown | University of Nottingham | 40 | 2012-05-01 | 2017-01-05 |
| Pharmacotoxicology of Trichloroethylene Metabolites Dichloroacetate, Genotyping, Leucine - Healthy | Not applicable | Terminated | University of Florida | 2 | 2011-08-01 | 2015-06-03 |
| Study of DCA (Dichloroacetate) in Combination With Cisplatin and Definitive Radiation in Head and Neck Carcinoma DCA (dichloroacetate), Placebo - Squamous Cell Carcinoma of the Head and Neck | Phase 2 | Completed | Sanford Health | 50 | 2011-05-01 | 2020-10-27 |
| Imaging and Biomarkers of Hypoxia in Solid Tumors PET Scan, EF5, Carbogen - Neoplasms | Phase 1 | Terminated | Stanford University | 28 | 2010-12-01 | 2017-11-06 |
| Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers Dichloroacetate, EF5 - Head and Neck Cancer, Head and Neck Cancers | Phase 1 | Completed | Daniel T. Chang | 17 | 2010-08-01 | 2022-06-16 |
| Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors Dichloroacetate - Brain Tumor, Glioblastoma | Phase 1 | Completed | University of Florida | 15 | 2010-04-01 | 2015-09-22 |
| A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours Dichloroacetate - Neoplasms | Phase 1 | Completed | AHS Cancer Control Alberta | 23 | 2007-12-01 | 2016-03-11 |
| Prevention of Dichloroacetate Toxicity Nitisinone (NTBC), Dichloroacetate, Low-tyrosin diet - Acidosis, Lactic, Chronic Disease | Not applicable | Completed | University of Florida | 30 | 2001-09-01 | 2015-03-25 |
| Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome Dichloroacetate - MELAS Syndrome | Phase 2 | Unknown | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 35 | 2000-03-01 | 2005-06-24 |
| Dichloroacetate Kinetics, Metabolism and Toxicology Dichloroacetate - Lactic Acidosis | Completed | National Institute of Environmental Health Sciences (NIEHS) | 100 | 1994-12-01 | 2006-09-04 | |
| Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access Dichloroacetate - Mitochondrial Enzyme Deficiencies | No longer available | University of Florida | 2017-08-08 |
Acidosis, Lactic (3) · Neoplasms (2) · Acidosis (1) · Brain Neoplasms (1) · Chronic Disease (1) · Diabetes Mellitus, Type 1 (1) · Endometriosis (1) · Genetic Diseases, Inborn (1) · Glioblastoma (1) · Head and Neck Neoplasms (1) · Hyperglycemia (1) · Insulin Resistance (1) · MELAS Syndrome (1) · Mitochondrial Diseases (1) · Rare Diseases (1)
University of Florida (5) · Yale University (2) · AHS Cancer Control Alberta (1) · Daniel T. Chang (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · National Institute of Environmental Health Sciences (NIEHS) (1) · Sanford Health (1) · Stanford University (1) · University of Edinburgh (1) · University of Nottingham (1)
United States (12) · United Kingdom (2) · Canada (1)
Peter W. Stacpoole, PhD, MD (3) · Raimund Herzog, MD (2) · Andrew W Horne, Prof (1) · Daniel T Chang (1) · Darryl C De Vivo, MD (1) · Dileep N Lobo, Professor (1) · Erin M. Dunbar, MD (1) · Evangelos Michelakis, M.D. (1) · Peter Venner, M.D. (1) · Peter W Stacpoole, PhD, MD (1) · Steven F Powell, MD (1)
PMID 24297161, PMID 33712086, PMID 35312941
R01ES014617 (1), UL1TR000064 (1)