10 active not recruiting, 6 recruiting, 5 completed, 1 terminated. 22 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 22 | Active not recruiting 10, Recruiting 6, Completed 5, Terminated 1 |
| Phase 2 | 2 | Active not recruiting 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Appendix Carcinoma, Metastatic Colorectal Carcinoma | Phase 3 | Recruiting | City of Hope Medical Center | 129 | 2026-10-01 | 2026-09-25 |
| Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations Biospecimen Collection, Computed Tomography, Fluorouracil - Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 94 | 2026-05-13 | 2026-05-22 |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study Biospecimen Collection, Cisplatin, Computed Tomography - Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 486 | 2025-10-07 | 2026-10-23 |
| Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Capecitabine - Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 356 | 2025-08-21 | 2026-08-25 |
| Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial Bevacizumab, Capecitabine, Cetuximab - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 408 | 2024-04-10 | 2026-09-24 |
| Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck Carboplatin, Cisplatin, Computed Tomography - Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma | Phase 3 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 290 | 2023-06-08 | 2026-09-14 |
| mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma Fluorouracil, Leucovorin Calcium, Oxaliplatin - Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma | Phase 3 | Recruiting | Alliance for Clinical Trials in Oncology | 382 | 2023-01-31 | 2026-10-02 |
| Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body Capecitabine, Fluorouracil, Leucovorin - Clinical Stage IV Esophageal Adenocarcinoma AJCC v8, Clinical Stage IV Gastric Cancer AJCC v8 | Phase 3 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 314 | 2020-05-26 | 2026-10-19 |
| Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery Capecitabine, Fluorouracil, Leucovorin - Colon Adenocarcinoma, Stage IIA Colon Cancer AJCC v8 | Phase 2 / Phase 3 | Active not recruiting | NRG Oncology | 635 | 2019-12-16 | 2025-05-07 |
| Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer Biospecimen Collection, Capecitabine, Carboplatin - Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8 | Phase 3 | Active not recruiting | NRG Oncology | 300 | 2019-06-26 | 2026-08-24 |
| Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer Atezolizumab, Biopsy of Bladder, Cisplatin - Bladder Urothelial Carcinoma, Muscle Invasive Bladder Carcinoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 475 | 2019-06-03 | 2026-08-28 |
| Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery Biospecimen Collection, Carboplatin, Cisplatin - Childhood Hepatocellular Carcinoma, Childhood Malignant Liver Neoplasm | Phase 3 | Active not recruiting | Children's Oncology Group | 537 | 2018-05-24 | 2026-09-14 |
| 5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab Panitumumab, Oxaliplatin, Leucovorin Calcium - Colorectal Adenocarcinoma, RAS Wild Type | Phase 3 | Terminated | University of Southern California | 4 | 2018-02-27 | 2020-06-11 |
| Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT Study Atezolizumab, Bevacizumab, Biospecimen Collection - Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v7 | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 120 | 2018-01-19 | 2026-10-26 |
| Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair Atezolizumab, Biospecimen Collection, Computed Tomography - Colon Adenocarcinoma, DNA Repair Disorder | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 712 | 2017-10-16 | 2026-10-28 |
| Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA Bone Scan, Cisplatin, Clinical Observation - EBV Infection, Stage II Nasopharyngeal Carcinoma AJCC v7 | Phase 2 / Phase 3 | Active not recruiting | NRG Oncology | 924 | 2014-07-01 | 2026-10-13 |
| Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection, Capecitabine - Pancreatic Adenocarcinoma, Pancreatic Ductal Adenocarcinoma | Phase 3 | Completed | National Cancer Institute (NCI) | 546 | 2010-04-05 | 2026-02-23 |
| Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Cisplatin, Dexrazoxane, Doxorubicin Hydrochloride - PRETEXT I Hepatoblastoma, PRETEXT II Hepatoblastoma | Phase 3 | Completed | National Cancer Institute (NCI) | 236 | 2009-09-15 | 2026-06-30 |
| Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Bevacizumab, Carboplatin, Cisplatin - Neck Squamous Cell Carcinoma of Unknown Primary, Recurrent Hypopharyngeal Squamous Cell Carcinoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 403 | 2008-08-08 | 2026-10-22 |
| Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer Amifostine, Cisplatin, Fluorouracil - Stage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7, Stage I Nasopharyngeal Undifferentiated Carcinoma AJCC v7 | Phase 3 | Completed | Children's Oncology Group | 111 | 2006-02-20 | 2022-10-25 |
Showing 20 of 22. Sign in to see all of them.
Colonic Neoplasms (4) · Colorectal Neoplasms (4) · Adenocarcinoma Of Esophagus (2) · Pancreatic Neoplasms (2) · Squamous Cell Carcinoma of Head and Neck (2) · Urinary Bladder Neoplasms (2) · Appendiceal Neoplasms (1) · Carcinoma (1) · Colorectal Neoplasms, Hereditary Nonpolyposis (1) · DNA Repair-Deficiency Disorders (1) · Epstein-Barr Virus Infections (1) · Fibrolamellar hepatocellular carcinoma (1) · Hepatoblastoma (1) · Hypopharyngeal Neoplasms (1) · Laryngeal Neoplasms (1)
National Cancer Institute (NCI) (8) · NRG Oncology (5) · ECOG-ACRIN Cancer Research Group (3) · Children's Oncology Group (2) · Alliance for Clinical Trials in Oncology (1) · City of Hope Medical Center (1) · SWOG Cancer Research Network (1) · University of Southern California (1)
United States (22) · Canada (9) · Puerto Rico (8) · Australia (4) · South Africa (2) · Belgium (1) · Brazil (1) · China (1) · Germany (1) · Hong Kong (1) · Israel (1) · Japan (1) · New Zealand (1) · Peru (1) · Saudi Arabia (1)
Afsaneh Barzi, MD (1) · Al B Benson (1) · Carlos Rodriguez-Galindo (1) · Carmen J Allegra (1) · David J Sher (1) · Frank A Sinicrope (1) · Gregory M Tiao (1) · Howard M Katzenstein (1) · Michael Lidsky (1) · Mustafa Raoof (1) · Nancy Y Lee (1) · Nataliya V Uboha (1) · Nina N Sanford (1)
PMID 21997132, PMID 23233715, PMID 28006055, PMID 30975630, PMID 31268130, PMID 31553639, PMID 31618129, PMID 31657981, PMID 31811950, PMID 33356421, PMID 33370024, PMID 34874751, PMID 35602670, PMID 37073741, PMID 37222189, PMID 37598723, PMID 38131628, PMID 38315963, PMID 39938471, PMID 40953502, PMID 41005671, PMID 41880612, PMID 42456089, PMID 42525921
U10CA180868 (7), U10CA180820 (5), U10CA180886 (3), U10CA021115 (2), U10CA021661 (2), U10CA098543 (2), U10CA180888 (2), P30CA014089 (1), P30CA033572 (1), U10CA012027 (1), U10CA180821 (1), U10CA180822 (1), U10CA180830 (1)