18 terminated. 18 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Terminated 18 |
| Phase 2 | 5 | Terminated 5 |
Follow CT: new trials by email Literature Review of CT trials Research Report on CT
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Genetically Engineered Cells (EGFRt/19-28z/IL-12 CAR T Cells) for the Treatment of Relapsed or Refractory CD19+ Hematologic Malignancies Biopsy, Biospecimen Collection, Bone Marrow Aspiration - Recurrent Chronic Lymphocytic Leukemia, Recurrent Diffuse Large B-Cell Lymphoma | Phase 1 | Terminated | Roswell Park Cancer Institute | 1 | 2024-11-26 | 2025-08-03 |
| NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma Biospecimen Collection, Computed Tomography, Heat Shock Factor 1 Pathway Inhibitor NXP800 - Advanced Cholangiocarcinoma, Metastatic Cholangiocarcinoma | Phase 1 | Terminated | Mayo Clinic | 7 | 2024-05-31 | 2025-12-22 |
| FID-007 Followed by Standard of Care Surgery in Head and Neck Cancer Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Head and Neck Squamous Cell Carcinoma | Phase 1 | Terminated | University of Southern California | 1 | 2024-04-01 | 2025-09-16 |
| Rintatolimod, Celecoxib and Interferon Alpha 2b With Pembrolizumab For the Treatment of Patients With Metastatic or Unresectable Triple Negative Breast Cancer Biopsy, Biospecimen Collection, Celecoxib - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Triple-Negative Breast Carcinoma | Phase 1 / Phase 2 | Terminated | Roswell Park Cancer Institute | 5 | 2024-02-16 | 2026-08-31 |
| Vudalimab (XmAb20717) in Combination With Standard of Care Treatment in Patients With Metastatic Castration Sensitive Prostate Cancer Abiraterone, Biospecimen Collection, Bone Scan - Castration-Sensitive Prostate Carcinoma, Metastatic Prostate Adenocarcinoma | Phase 1 | Terminated | Emory University | 4 | 2023-08-03 | 2025-09-15 |
| E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma Dabrafenib, MEK-1/MEKK-1 Inhibitor E6201, Biospecimen Collection - Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Terminated | Mayo Clinic | 13 | 2022-10-20 | 2025-08-19 |
| T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers IL-2 (Aldesleukin), Cyclophosphamide, KK-LC-1 TCR - Kita-kyushu Lung Cancer Antigen 1, Human | Phase 1 | Terminated | National Cancer Institute (NCI) | 36 | 2022-03-08 | 2025-12-02 |
| Testing the Combination of Two Immunotherapy Drugs (Magrolimab and Dinutuximab) in Patients With Relapsed or Refractory Neuroblastoma or Relapsed Osteosarcoma Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - High Risk Neuroblastoma, Recurrent Neuroblastoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 12 | 2021-08-31 | 2026-06-30 |
| 11C-YJH08 PET Imaging for Detection of Glucocorticoid Receptor Expression Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 | Terminated | Rahul Aggarwal | 2 | 2021-08-10 | 2025-05-20 |
| Testing the Addition of an Anti-cancer Drug, Hu5F9-G4 (Magrolimab), to the Usual Chemotherapy Treatment (Mogamulizumab) in T-Cell (a Type of Immune Cell) Lymphoma That Has Returned After Treatment or Does Not Respond to Treatment Biospecimen Collection, Computed Tomography, Magrolimab - Mycosis Fungoides, Recurrent Mycosis Fungoides | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 8 | 2021-04-06 | 2025-10-16 |
| Effect of Androgen Receptor Signaling Inhibitors on 68Ga-PSMA-11 PET/CT Imaging in Patients With Castration-Resistant Prostate Cancer Computed Tomography, Gallium Ga 68 Gozetotide, Positron Emission Tomography - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 | Terminated | Jonsson Comprehensive Cancer Center | 9 | 2020-04-16 | 2022-09-21 |
| Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients Cyclophosphamide, Fludarabine, Aldesleukin - Gastrointestinal Cancer, Pancreatic Cancer | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 5 | 2019-05-16 | 2026-05-19 |
| Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer 18F-FHBG, Aldesleukin, Busulfan - HLA-A*0201 Positive Cells Present, Locally Advanced Malignant Neoplasm | Phase 1 | Terminated | Jonsson Comprehensive Cancer Center | 5 | 2017-07-26 | 2023-11-01 |
| 18F-FMAU PET/CT in Diagnosing and Characterizing Prostate Cancer CAT, 18F-FMAU, Laboratory Biomarker Analysis - Prostate Neoplasm | Phase 1 | Terminated | University of Southern California | 18 | 2016-09-12 | 2023-09-07 |
| Copper Cu 64-DOTA-B-Fab PET/CT in Imaging Patients With Ovarian and Breast Cancer Computed Tomography, Copper Cu 64-DOTA B-Fab, Laboratory Biomarker Analysis - Ovarian Carcinoma, Breast Carcinoma | Phase 1 | Terminated | Sanjiv Sam Gambhir | 2 | 2016-08-01 | 2018-04-05 |
| Enzalutamide With Ribociclib in Treating Patients With Metastatic Castrate-Resistant, Chemotherapy Naive Prostate Cancer That Retains Retinoblastoma Expression Enzalutamide, Ribociclib, Laboratory Biomarker Analysis - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 / Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 52 | 2015-12-01 | 2026-04-22 |
| Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography - Advanced Malignant Solid Neoplasm, Anal Carcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 79 | 2015-10-21 | 2026-01-21 |
| GA-68 DOTA-TOC of Somatostatin Positive Malignancies Computed Tomography (CT), Gallium Ga 68-Edotreotide, Magnetic Resonance Imaging (MRI) - Neuroendocrine Tumor, Paraganglioma | Phase 1 / Phase 2 | Terminated | University of California, San Francisco | 300 | 2014-06-23 | 2019-11-12 |
Prostatic Neoplasms (5) · Neoplasm Metastasis (2) · Neuroblastoma (2) · Triple Negative Breast Neoplasms (2) · Anus Neoplasms (1) · Brain Neoplasms (1) · Breast Neoplasms (1) · Carcinoid Tumor (1) · Carcinoma (1) · Cholangiocarcinoma (1) · Colonic Neoplasms (1) · Gastrointestinal Neoplasms (1) · HIV Infections (1) · Klatskin Tumor (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1)
National Cancer Institute (NCI) (5) · Jonsson Comprehensive Cancer Center (2) · Mayo Clinic (2) · Roswell Park Cancer Institute (2) · University of Southern California (2) · Emory University (1) · Rahul Aggarwal (1) · Sanjiv Sam Gambhir (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University of California, San Francisco (1)
United States (18) · Australia (1) · Canada (1)
Bassel Nazha, MD, MPH (1) · Ellis Levine, MD (1) · Francisco J Hernandez-ILizaliturri (1) · Hani M. Babiker, MD (1) · Hossein Jadvar, MD (1) · Jacob Thomas, MD (1) · James C Yang, M.D. (1) · Jeremie Calais (1) · Lakshmi Rajdev (1) · Michael S Khodadoust (1) · Mitesh J. Borad, MD (1) · Rahul Aggarwal, MD (1) · Robbie G Majzner (1) · Sanjiv Gambhir (1) · Scott M Norberg, D.O. (1)
PMID 33677480, PMID 37902861, PMID 37962072, PMID 40593578, PMID 40717483, PMID 41698328
P30CA014089 (2), P01CA234212 (1), P30CA015704 (1), P30CA138292 (1), R01MH115043 (1), R21EB017568 (1), U01CA121947 (1), U01CA154967 (1), UM1CA121947 (1), UM1CA186717 (1), UM1CA228823 (1)