9 completed, 2 terminated, 1 recruiting, 1 unknown. 13 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 9, Terminated 2, Recruiting 1, Unknown 1 |
| Phase 2 | 2 | Terminated 1, Unknown 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial) Losartan, Amlodipine, Placebo - Coarctation of Aorta, High Blood Pressure | Phase 3 | Recruiting | Mayo Clinic | 120 | 2024-04-01 | 2026-09-11 |
| Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan and Other ARBs on Outcomes of Coronavirus Infection? Losartan, Valsartan, Azilsartan - Covid19, SARS-CoV Infection | Phase 3 | Terminated | University of British Columbia | 341 | 2020-10-09 | 2023-02-16 |
| COVID MED Trial - Comparison Of Therapeutics for Hospitalized Patients Infected With COVID-19 Losartan, Placebo - SARS-CoV-2 Infection | Phase 2 / Phase 3 | Terminated | Bassett Healthcare | 15 | 2020-04-06 | 2022-03-24 |
| Chinese Medicine Treat for Hypertensive Renal Injury Losartan 100Mg Tab, Qianyangyuyin 20g Granule, placebo - Hypertension, Renal Injury | Phase 2 / Phase 3 | Unknown | Jiangsu Province Hospital of Traditional Chinese Medicine | 520 | 2019-09-10 | 2019-09-06 |
| An Efficacy and Safety Study in Children 6 to Less Than 18 Years of Age With Hypertension Azilsartan Medoxomil Low-dose, Losartan, Placebo for Azilsartan Medoxomil - Hypertension | Phase 3 | Completed | Arbor Pharmaceuticals, Inc. | 377 | 2015-03-30 | 2025-02-25 |
| Efficacy and Safety of Losartan in Children With Ig A Nephropathy Losartan - Glomerulonephritis, IGA | Phase 3 | Completed | Seoul National University Hospital | 37 | 2014-10-01 | 2018-10-10 |
| Efficacy and Safety of Losartan in Pediatric Chronic Kidney Disease With Tubular Proteinuria Losartan, Placebo - Proteinuria | Phase 3 | Completed | Seoul National University Hospital | 58 | 2014-09-01 | 2018-10-10 |
| Efficacy and Safety of HL-040XC in Essential Hypertension and Hyperlipidemia Atorvastatin, Losartan, Placebo - Essential Hypertension, Hyperlipidemia | Phase 3 | Completed | HanAll BioPharma Co., Ltd. | 356 | 2012-03-01 | 2015-09-23 |
| Study of Losartan in Pediatric Patients With Hypertension (MK-0954-337) losartan potassium - Hypertension | Phase 3 | Completed | Organon and Co | 101 | 2009-03-01 | 2024-06-18 |
| Effects of Losartan Versus Atenolol on Aortic and Cardiac Muscle Stiffness in Adults With Marfan Syndrome Atenolol, Losartan - Marfan Syndrome | Phase 3 | Completed | Brigham and Women's Hospital | 40 | 2007-10-01 | 2014-09-09 |
| Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome Losartan Potassium, Atenolol - Marfan Syndrome | Phase 3 | Completed | Carelon Research | 608 | 2007-01-01 | 2025-03-07 |
| Renoprotection in Early Diabetic Nephropathy in Pima Indians Losartan, Placebo - Diabetic Nephropathy | Phase 3 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 170 | 1995-08-01 | 2021-03-25 |
| A Study to Investigate the Efficacy and Safety of Different Doses of Losartan Potassium (MK0954-011) losartan potassium, Placebo, Enalapril - Hypertension | Phase 3 | Completed | Merck Sharp & Dohme LLC | 576 | 1990-12-01 | 2015-08-27 |
Hypertension (5) · COVID-19 (2) · Coronavirus Infections (2) · Essential Hypertension (2) · Marfan Syndrome (2) · Proteinuria (2) · Acute Kidney Injury (1) · Aortic Coarctation (1) · Diabetes Mellitus, Type 2 (1) · Diabetic Nephropathies (1) · Dissection, Ascending Aorta (1) · Glomerulonephritis, IGA (1) · Hyperlipidemias (1) · Renal Insufficiency, Chronic (1) · Respiratory Distress Syndrome (1)
Seoul National University Hospital (2) · Arbor Pharmaceuticals, Inc. (1) · Bassett Healthcare (1) · Brigham and Women's Hospital (1) · Carelon Research (1) · HanAll BioPharma Co., Ltd. (1) · Jiangsu Province Hospital of Traditional Chinese Medicine (1) · Mayo Clinic (1) · Merck Sharp & Dohme LLC (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Organon and Co (1) · University of British Columbia (1)
United States (6) · South Korea (3) · Canada (2) · Argentina (1) · Belgium (1) · Brazil (1) · Bulgaria (1) · Colombia (1) · France (1) · Hungary (1) · Italy (1) · Mexico (1) · Poland (1) · South Africa (1) · Turkey (Türkiye) (1)
Hee Gyung Kang, Ph.D (2) · Alexander Egbe, MBBS, MPH (1) · Chang-Gyu Park, Medicine (1) · Daniel Freilich, MD (1) · James A Russell, MD (1) · Karen Tran, MD (1) · Mark A Creager, MD (1) · Ming Liu (1) · Robert G Nelson, M.D. (1) · Ron Lacro, MD (1) · Steve Caras, MD (1) · Zhuyuan Fang (1)
PMID 22718189, PMID 23545707, PMID 23622922, PMID 24875194, PMID 25405392, PMID 27612501, PMID 29948025, PMID 31573977, PMID 34027894, PMID 34437304, PMID 34473343, PMID 38682786, PMID 39325643
R01HL162830 (1), U01HL068270 (1)