40 completed, 30 unknown, 9 not yet recruiting, 7 recruiting. 93 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 93 | Completed 40, Unknown 30, Not yet recruiting 9, Recruiting 7, Terminated 3, Withdrawn 3, Suspended 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suzetrigine Following Urogynecologic Surgery: Investigation of Postoperative Pain Management Suzetrigine, Placebo - Pelvic Organ Prolapse (POP), Postoperative Pain | Phase 4 | Not yet recruiting | Aditi Talkad | 48 | 2026-11-01 | 2026-10-02 |
| A Bundled Intervention to End Opioid Overdoses Bundled intervention (Experimental), control group, Buprenorphine (Experimental) - Opioid Use Disorder, Opioid Overdose | Phase 4 | Recruiting | University of Alabama at Birmingham | 160 | 2026-09-07 | 2026-10-02 |
| Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease Prophylactic Transfusion Intervention group: Transfusion, Control group - Sickle Cell Disease, Pregnancy Related | Phase 4 | Withdrawn | Emory University | 2026-09-01 | 2026-10-19 | |
| The Clinical Research of Traditional Chinese Medicine Formula Bushen Huoxue Simiao Formula, control group - Urologic Injuries, Kidney Disease | Phase 4 | Not yet recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 80 | 2026-08-31 | 2026-08-04 |
| Efficacy and Safety of Anrikefon Injection for Multimodal Postoperative Analgesia in Patients Undergoing Laparoscopic Hepatectomy Anruikefon 1 μg/kg per dose Group, Anruikefon 100 μg per dose Group, Control group - Postoperative Acute Pain | Phase 4 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 117 | 2026-08-30 | 2026-09-03 |
| HORUS-Cytomegalovirus Open Proof-of-concept Exploratory Trial 50% reduction in the dose of MPA, Switch from MPA to a mammalian target of rapamycin inhibitor (mTORi), together with an adapted dose of tacrolimus, standard antiviral therapy along with maintenance of their initial immunosuppressive therapy. - CMV Infection | Phase 4 | Not yet recruiting | Oriol Manuel | 100 | 2026-04-01 | 2026-05-06 |
| The TRIBECA Study (TRIessence/Byqlovi for Easier CAtaract Surgery) Triamcinolone (Optional), control group - Post Cataract Surgery | Phase 4 | Not yet recruiting | Research Insight LLC | 40 | 2026-04-01 | 2026-03-31 |
| Randomized Trial of SGLT2i in Heart Transplant Recipients Empagliflozin, Placebo - Heart Transplant, Cardiovascular Disease | Phase 4 | Recruiting | VA Office of Research and Development | 200 | 2026-01-20 | 2026-01-22 |
| Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery Midazolam, Remimazolam - Delirium, Critical Illness | Phase 4 | Not yet recruiting | Yonsei University | 300 | 2025-12-01 | 2025-12-04 |
| The Treatment of Liver Injury After Liver Resection With Polyene Phosphatidylcholine Experimental Group, control group - Hepatocellular Carcinoma (HCC), Liver Diseases | Phase 4 | Recruiting | Anhui Provincial Hospital | 96 | 2025-11-10 | 2026-05-11 |
| Pegmolesatide Treatment for Anemia in Patients Undergoing Long-term Dialysis The rHuEPO Monotherapy Group (Control Group), The Pegmolesatide and Roxadustat Combination Therapy Group (Exploratory Group), The Pegmolesatide Monotherapy Group (Experimental group) - Dialysis; Complications, Chronic Kidney Disease 5D | Phase 4 | Recruiting | Chinese PLA General Hospital | 240 | 2025-08-01 | 2025-09-12 |
| IMPACT OF SUPPLEMENTATION WITH LOW MOLECULAR WEIGHT HYDROLYZED COLLAGEN AND VERISOL ON THE EXPRESSION OF LINES, SKIN QUALITY, AND LEVELS OF KLOTHO, VEGF, AND TGF-BETA IN THE EYE REGION Supplementation with Verisol®, Supplementation with Peptech® 2.5G, Supplementation with Peptech® 10.0G - Skin Health, Collagen Supplementation | Phase 4 | Not yet recruiting | Federal University of São Paulo | 150 | 2025-06-09 | 2025-05-14 |
| Lidocaine Infusion Versus Magnesium Infusion in Decreasing Fentanyl Requirements in Endoscopic Sinus Surgeries Lidocaine group, Magnesium group, Control group - Enhanced Recovery, Functional Endoscopic Sinus Surgery | Phase 4 | Not yet recruiting | Cairo University | 156 | 2025-05-10 | 2025-05-11 |
| A Study on the Combined Use of Tocilizumab and Flupentixol-Melitracen in the Treatment of Thyroid-Associated Ophthalmopathy Tocilizumab(400mg) combined with Flupentixol Melitracen(0.5mg:10mg), Tocilizumab(400mg) - Thyroid-Associated Ophthalmopathy | Phase 4 | Recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 60 | 2024-12-12 | 2025-04-16 |
| Interpectoral-pectoserratus Plane Block for Minimally Invasive Aortic Valve Replacement Via Right Anterior Minithoracotomy Levobupivacaine Hydrochloride 0.25 % Injectable Solution, Sodium chloride 0.9% - Analgesic Effect | Phase 4 | Recruiting | Algemeen Ziekenhuis Maria Middelares | 144 | 2024-09-01 | 2026-10-28 |
| Chronic Exertional Compartment Syndrome (CECS) Treated With Abobotulinumtoxin A AbobotulinumtoxinA, Placebo - Compartment Syndrome of Leg | Phase 4 | Completed | Emory University | 3 | 2024-04-25 | 2025-10-21 |
| ESPB vs iPACK+ACB in Total Knee Arthroplasty Ropivacaine 0.2% Injectable Solution, control group - Knee Arthritis, Knee Arthropathy | Phase 4 | Unknown | Poznan University of Medical Sciences | 60 | 2024-04-01 | 2024-03-08 |
| The Effects of DPPIs on Cognitive Function of Diabetic Patients Control group, DPP-4 inhibitor group, DPP-4 inhibitor + metformin group - Cognitive Impairment | Phase 4 | Unknown | Beni-Suef University | 105 | 2023-12-30 | 2023-12-11 |
| Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery Micronized purified flavonoid fraction(Daflon 1000mg), Placebo - Anal Fistula | Phase 4 | Completed | Taipei Medical University Shuang Ho Hospital | 106 | 2023-12-13 | 2025-05-16 |
| Clinical Study of GKT in Diabetes Related Dementia Ginkgo Ketone Ester Tablets, placebo - Dementia | Phase 4 | Unknown | Shanghai 10th People's Hospital | 370 | 2023-12-01 | 2023-11-13 |
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Diabetes Mellitus, Type 2 (5) · Pain, Postoperative (4) · COVID-19 (2) · Cognitive Dysfunction (2) · Diabetic Foot (2) · Heart Arrest (2) · Hypertrophy, Left Ventricular (2) · Infections (2) · Kidney Diseases (2) · Kidney Failure, Chronic (2) · Pain (2) · Renal Insufficiency, Chronic (2) · ST Elevation Myocardial Infarction (2) · Stroke (2) · Acute Pain (1)
Cairo University (6) · Yonsei University (4) · The Affiliated Hospital of Xuzhou Medical University (3) · Chulalongkorn University (2) · Emory University (2) · Federal University of São Paulo (2) · Otsuka Beijing Research Institute (2) · Tanta University (2) · University of Alabama at Birmingham (2) · Abant Izzet Baysal University (1) · Aditi Talkad (1) · Ain Shams University (1) · Algemeen Ziekenhuis Maria Middelares (1) · Anhui Provincial Hospital (1) · Assistance Publique - Hôpitaux de Paris (1)
China (18) · United States (11) · Egypt (8) · South Korea (8) · Spain (6) · Brazil (4) · Turkey (Türkiye) (3) · Belgium (2) · France (2) · Israel (2) · Italy (2) · Taiwan (2) · Albania (1) · Bulgaria (1) · Germany (1)
Adriano M Almeida, MD (1) · Ahmed Abdalla Mohamed, M.D (1) · Alexander M Ponizovsky, MD, PhD (1) · Alvaro Sanchez (1) · Amanda White, MD (1) · Arnaldo J Hernandez, MD, PhD (1) · Ayman A Yousef, Professor (1) · Bart Vaes, MD (1) · Benjamin Bush, M.D. (1) · Carmen Silvestre (1) · Changzhen Shang (1) · Chueng-He Lu, M.D. (1) · Chung H Kau, BDS, PhD (1) · Dalia G Abdel Nasser, M.B.B.Ch. (1) · Dina M Mohamed, M.D. (1)
PMID 12607706, PMID 12767787, PMID 15791442, PMID 17717368, PMID 19043850, PMID 19741187, PMID 20219196, PMID 23158830, PMID 23354282, PMID 23594859, PMID 23706726, PMID 24355412, PMID 24405824, PMID 24463478, PMID 2469747, PMID 25926349, PMID 26189118, PMID 26289708, PMID 26531676, PMID 26869575, PMID 26910697, PMID 27109174, PMID 27118118, PMID 27152422, PMID 27206733, PMID 28034730, PMID 28039902, PMID 28606491, PMID 28687146, PMID 28886621, PMID 28966311, PMID 29495982, PMID 30579408, PMID 31118574, PMID 31147987, PMID 31331757, PMID 32210537, PMID 35141873, PMID 36659633, PMID 36812501, PMID 37913818, PMID 37954906, PMID 38470420, PMID 38754593, PMID 38767196, PMID 39313857, PMID 40225393, PMID 40705792, PMID 41588262, PMID 41637916
2014 (1), 2019 (1), 2025 (1), P20RR017696 (1), R33DA062351 (1)