Effects Of Supplementation With New Technology for Obtaining Low Molecular Weight Hydrolyzed Collagen Vs. Verisol Collagen on Expression Lines, Skin Quality in the Orbicularis Oculi Region, And Serum Levels of Klotho, VEGF, and TGF-Beta
| Registry | NCT06971029 |
|---|---|
| Status | Not yet recruiting |
| Phase | Phase 4 |
| Study type | Interventional; randomized, parallel, masking: none, prevention |
| Enrollment | 150 (Estimated) |
| Sponsor | Federal University of São Paulo (Other) |
| Conditions | Skin Health, Collagen Supplementation, Growth Factors |
| Interventions | Supplementation with Verisol®, Supplementation with Peptech® 2.5G, Supplementation with Peptech® 10.0G, Control group (Dietary supplement, diagnostic test) |
| Dates | start 2025-06-09 (estimated), primary completion 2025-09-01 (estimated), completion 2025-12-01 (estimated), first posted 2025-05-14, last updated 2025-05-14 |
Related Papers Related Patents Related Grants Related Experts
All trials for Skin Health All trials for Collagen Supplementation All trials of Supplementation with Verisol® All trials of Supplementation with Peptech® 2.5G
Skin is the largest organ of the human body and performs various vital functions, including protection against external agents, regulation of body temperature, and sensory perception. As we age, our skin undergoes a series of changes that can be noticeable both visually and physically. One of the most evident changes is the appearance of wrinkles and fine lines, resulting from decreased skin elasticity and reduced production of collagen and elastin. Nutrition plays a key role in skin health, influencing its structure, function, and ability to defend against damage and diseases. However, it is unknown to what extent supplementation with different types of collagens can attenuate these effects in middle-aged women. Therefore, the present study aims to recruit 150 middle-aged women (35-58 years old) who will be randomized into three groups, Verisol Collagen 2.5 g/day, Peptech Collagen 2.5 g/day, and Peptech Collagen 10 g/day, 7 days a week, for 3 months. Skin hydration, oiliness, and flexibility, as well as the number and depth of expression lines, will be evaluated, along with plasma levels of Klotho, VEGF, and TGF-beta. Data will be analyzed, and graphs constructed using GraphPad Prism 5.0 software (California, USA). The normality distribution of the data will be assessed by the Kolmogorov-Smirnov test. Data with parametric distribution will be subjected to paired Student's t-test for intragroup comparison, and unpaired t-test will be used for comparison between groups. Significance levels will be considered statistically different for p<0.05.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Verisol Collagen 2.5 g/day | Experimental | Dietary Supplement: Supplementation with Verisol® | Supplementation with Verisol® collagen will be administered at a dose of 2.5 g/day, diluted in water or water-based juice (300-500 mL), and should be consumed daily, 7 days a week, for 3 months. |
| Peptech Collagen 2.5 g/day (GCP 2.5) | Experimental | Dietary Supplement: Supplementation with Peptech® 2.5G | Supplementation with Peptech® collagen will be administered at a dose of 2.5 g/day, diluted in water or water-based juice (300-500 mL), and should be consumed daily, 7 days a week, for 3 months. |
| eptech Collagen 10 g/day (GCP 10) | Experimental | Dietary Supplement: Supplementation with Peptech® 10.0G | Supplementation with Peptech® collagen will be administered at a dose of 10.0 g/day, diluted in water or water-based juice (300-500 mL), and should be consumed daily, 7 days a week, for 3 months. |
| Group Control | Other | Diagnostic Test: Control group | he control group will undergo the tests but will not receive supplementation. |
Sex: Female, ages: 35 Years to 58 Years, accepts healthy volunteers
Inclusion Criteria: * "Inclusion criteria require that volunteers be between 35 and 58 years old, have been sedentary for at least one year, and, after reading and understanding all stages of the study, agree to and sign the informed consent form (ICF). Exclusion Criteria: * "Exclusion criteria include undergoing facial aesthetic procedures involving hyaluronic acid or botulinum toxin, being an active or passive smoker within the past 3 years, using protein- or amino acid-based supplements within the past 6 months, or using cosmetics with skin-repairing properties in the orbicularis oculi region.