25 completed, 4 withdrawn, 1 unknown. 30 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 30 | Completed 25, Withdrawn 4, Unknown 1 |
Follow Chlorthalidone: new trials by email Literature Review of Chlorthalidone trials Research Report on Chlorthalidone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hypertension candesartan cilexetil + chlorthalidone + amlodipine, Exforge HCT® (valsartan 160mg + hydrochlorothiazide 12.5mg + amlodipine 5mg) - Hypertension | Phase 3 | Completed | Hospital Israelita Albert Einstein | 702 | 2023-08-22 | 2025-07-09 |
| Efficacy and Safety of Losartan/Chlorthalidone vs Losartan/Hydrochlorothiazide in Essential Arterial Hypertension Losartan/Chlorthalidone in fixed dose, Losartan + hydrochlorothiazide in fixed dose - Essential Arterial Hypertension | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 163 | 2022-06-30 | 2025-03-13 |
| Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension. Chlorthalidone 25 mg, Hydrochlorothiazide 50 mg, Amiloride 20 mg - Hypertension | Phase 3 | Unknown | Hospital de Clinicas de Porto Alegre | 84 | 2019-11-13 | 2019-12-09 |
| Efficacy and Safety of Candesartan Associated With Chlorthalidone Versus Losartan Associated With Hydrochlorothiazide (Hyzaar®) in Essential Hypertension Control Candesartan + Chlorthalidone, Losartan+hydrochlorothiazide - Essential Arterial Hypertension | Phase 3 | Withdrawn | EMS | 2016-11-01 | 2017-01-19 | |
| Efficacy and Safety of Candesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control Candesartan + Chlorthalidone (8mg+12,5mg), Candesartan + Chlorthalidone (8 mg + 25 mg), losartan+hydrochlorothiazide - Essential Arterial Hypertension | Phase 3 | Withdrawn | EMS | 2016-11-01 | 2017-01-19 | |
| Diuretic Comparison Project Hydrochlorothiazide (HCTZ), Chlorthalidone (CTD) - Hypertension | Phase 3 | Completed | VA Office of Research and Development | 20723 | 2016-06-15 | 2024-05-22 |
| Efficacy & Safety Study of YH22162 vs Telmisartan/Amlodipine in Patients With Hypertension Inappropriately Controlled on Telmisartan/Amlodipine Treatment telmisartan/amlodipine 40/5mg, YH22162 40/5/12.5 mg, telmisartan/amlodipine 80/5mg - Hypertension | Phase 3 | Completed | Yuhan Corporation | 381 | 2015-12-01 | 2024-11-12 |
| A Study to Evaluate Efficacy and Safety of HCP1401 for Stage 2 Hypertension Patients Not Controlled by HCP0605 HCP1401, HCP0605 - Hypertension | Phase 3 | Completed | Hanmi Pharmaceutical Company Limited | 340 | 2015-04-01 | 2016-10-20 |
| Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea Chlorthalidone plus amiloride, Amlodipine - Hypertension, Sleep Apnea | Phase 3 | Completed | Hospital de Clinicas de Porto Alegre | 69 | 2014-12-07 | 2018-06-14 |
| Effect of Antihypertensive Agents Over Sleep Apnea Diuretics, Calcium Channel Blockers - Hypertension, Obstructive Sleep Apnea | Phase 3 | Completed | Hospital de Clinicas de Porto Alegre | 53 | 2014-12-01 | 2016-07-14 |
| Efficacy/Safety Study of Valsartan and Chlorthalidone Conjugate Treatment Compared to Simple Treatment for Hypertension GROUP A: Valsartan plus Chlorthalidone, GROUP B: Valsartan, GROUP C: Chlorthalidone - Hypertension | Phase 3 | Completed | Farma de Colombia SA | 124 | 2013-04-01 | 2016-01-26 |
| Thiazide Diuretics for Hypertension in Kidney Transplant Recipients Using Tacrolimus Chlorthalidone, Amlodipine - Hypertension, Kidney Transplantation | Phase 3 | Completed | Erasmus Medical Center | 49 | 2013-01-18 | 2017-06-16 |
| Safety and Efficacy of Chlorthalidone + Amiloride to Elderly Patients Treatment With Arterial Hypertension Chlorthalidone 25 mg + amiloride hydrochloride 5 mg, Higroton® Laboratório Novartis - Arterial Hypertension | Phase 3 | Completed | Eurofarma Laboratorios S.A. | 246 | 2011-08-01 | 2025-06-12 |
| Long-Term Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Hypertension and Kidney Disease Azilsartan medoxomil and chlorthalidone, Olmesartan medoxomil and hydrochlorothiazide - Safety | Phase 3 | Completed | Takeda | 153 | 2011-03-01 | 2013-12-13 |
| Hypertension Prevention in Pre-Hypertensive Individuals Chlorthalidone plus amiloride, placebo - Pre-hypertension, Hypertension | Phase 3 | Completed | Hospital de Clinicas de Porto Alegre | 730 | 2010-07-01 | 2015-02-12 |
| Diuretics and Angiotensin-Receptor Blocker Agents in Patients With Stage I Hypertension losartan, Chlorthalidone plus amiloride - Hypertension, Cardiovascular Disease | Phase 3 | Completed | Hospital de Clinicas de Porto Alegre | 655 | 2010-07-01 | 2015-02-12 |
| Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Moderate to Severe Hypertension. Azilsartan medoxomil and chlorthalidone, Olmesartan medoxomil and hydrochlorothiazide - Essential Hypertension | Phase 3 | Completed | Takeda | 1071 | 2010-01-01 | 2012-02-07 |
| Safety and Tolerability of Azilsartan Medoxomil Plus Chlorthalidone Compared to Olmesartan Medoxomil Plus Hydrochlorothiazide in Participants With Essential Hypertension Azilsartan medoxomil and chlorthalidone, Olmesartan medoxomil and hydrochlorothiazide - Essential Hypertension | Phase 3 | Completed | Takeda | 837 | 2009-10-01 | 2012-11-12 |
| Efficacy and Safety of Azilsartan Medoxomil Plus Chlorthalidone in Participants With Moderate to Severe Hypertension Azilsartan medoxomil and chlorthalidone, Olmesartan medoxomil-hydrochlorothiazide - Essential Hypertension | Phase 3 | Completed | Takeda | 1085 | 2009-03-01 | 2012-03-13 |
| Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone in Participants With Moderate to Severe Hypertension Azilsartan medoxomil and chlorthalidone, Azilsartan medoxomil and hydrochlorothiazide - Essential Hypertension | Phase 3 | Completed | Takeda | 609 | 2009-02-01 | 2012-02-07 |
Showing 20 of 30. Sign in to see all of them.
Hypertension (27) · Cardiovascular Diseases (13) · Vascular Diseases (6) · Heart Diseases (5) · Essential Hypertension (4) · Coronary Disease (2) · Diabetes Mellitus (2) · Hypercholesterolemia (2) · Sleep Apnea Syndromes (2) · Atherosclerosis (1) · Cerebrovascular Disorders (1) · Death, Sudden, Cardiac (1) · Diabetes Mellitus, Type 2 (1) · Heart Arrest (1) · Heart Failure (1)
Takeda (7) · Hospital de Clinicas de Porto Alegre (5) · EMS (4) · National Heart, Lung, and Blood Institute (NHLBI) (4) · Erasmus Medical Center (1) · Eurofarma Laboratorios S.A. (1) · Farma de Colombia SA (1) · Hanmi Pharmaceutical Company Limited (1) · Hospital Israelita Albert Einstein (1) · Laboratorios Silanes S.A. de C.V. (1) · University of California, San Francisco (1) · University of Florida (1) · VA Office of Research and Development (1) · Yuhan Corporation (1)
United States (8) · Brazil (7) · Mexico (3) · Netherlands (3) · Canada (2) · Chile (2) · Germany (2) · Poland (2) · Russia (2) · South Korea (2) · Austria (1) · Bulgaria (1) · Colombia (1) · Ecuador (1) · Latvia (1)
Sandra C Fuchs, MD, PhD (2) · Adriana C Forti (1) · Albert Oberman (1) · Areef Ishani, MD MS (1) · Barry Davis (1) · C. Hawkins (1) · Cheulho Kim, M.D.,Ph.D. (1) · Daniela G Barbieri (1) · Denise Simons-Morton, MD, PhD (1)
PMID 41903707, PMID 16651474, PMID 17846352, PMID 18000186, PMID 18227370, PMID 18539917, PMID 18676075, PMID 19001024, PMID 19898642, PMID 19926008, PMID 20061358, PMID 20061360, PMID 20215456, PMID 20228401, PMID 20228404, PMID 20427682, PMID 20571135, PMID 20587587, PMID 20594588, PMID 21366473, PMID 21663644, PMID 21849262, PMID 21958949, PMID 21969009, PMID 22019270, PMID 22049171, PMID 22179956, PMID 22235820, PMID 22374637, PMID 22396585, PMID 22431578, PMID 22432114, PMID 22450889, PMID 22470539, PMID 22490878, PMID 22515638, PMID 22619083, PMID 22646230, PMID 22710649, PMID 22723577, PMID 22939358, PMID 23033246, PMID 23194494, PMID 23238658, PMID 23412077, PMID 23529173, PMID 23990163, PMID 24170759, PMID 24283598, PMID 24296848
2008 (2), N01HC95178 (1), N01HC95179 (1), N01HC95180 (1), N01HC95181 (1), N01HC95182 (1), N01HC95183 (1), N01HC95184 (1), P20RR011104 (1), R01HL030171 (1), R01HL036821 (1), R01HL079352 (1)