40 completed. 40 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 40 | Completed 40 |
| Phase 2 | 7 | Completed 7 |
Follow BOTOX: new trials by email Literature Review of BOTOX trials Research Report on BOTOX
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess BOTOX Injections for the Change of Masseter Muscle Prominence in Adult Participants BOTOX, Placebo - Masseter Muscle Prominence | Phase 3 | Completed | AbbVie | 207 | 2024-04-30 | 2026-08-12 |
| A Study to Assess BOTOX Injections in Adult Participants for the Change of Masseter Muscle Prominence BOTOX, Placebo - Masseter Muscle Prominence | Phase 3 | Completed | AbbVie | 202 | 2024-04-22 | 2026-08-25 |
| A Study to Assess the Adverse Events and Effectiveness of BOTOX Injections for the Treatment of Moderate to Severe Forehead Lines in Chinese Adult Participants BOTOX, Placebo - Forehead Lines | Phase 3 | Completed | AbbVie | 140 | 2023-12-12 | 2025-08-28 |
| A Study to Assess Adverse Events and Change of Masseter Muscle Prominence Using BOTOX Injections in Adult Participants BOTOX, Placebo for BOTOX - Masseter Muscle Prominence | Phase 3 | Completed | AbbVie | 259 | 2023-11-22 | 2026-07-06 |
| A Study to Assess the Effectiveness of BOTOX (Botulinum Toxin Type A) Injections for the Change of Masseter Muscle Prominence in Adult Participants BOTOX, Placebo - Masseter Muscle Prominence | Phase 3 | Completed | AbbVie | 249 | 2023-10-17 | 2025-12-10 |
| Botulinum Toxin A in Frequent and Chronic Tension-type Headache Botulinum Toxin Type A in saline water, Isotone saline water - Tension-Type Headache | Phase 3 | Completed | Helse Nord-Trøndelag HF | 66 | 2022-10-03 | 2025-03-13 |
| A Study To Assess the Safety of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence OnabotulinumtoxinA - Platysma Prominence | Phase 3 | Completed | AbbVie | 292 | 2021-11-16 | 2024-12-05 |
| Study to Evaluate the Efficacy and Safety of MBA-P01 in Subjects With Glabellar Lines MBA-P01, BOTOX - Glabellar Frown Lines | Phase 3 | Completed | Medytox Korea | 318 | 2021-08-30 | 2022-06-03 |
| A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence OnabotulinumtoxinA, Placebo - Platysma Prominence | Phase 3 | Completed | AbbVie | 426 | 2021-08-10 | 2024-08-20 |
| A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Moderate to Severe Platysma Prominence OnabotulinumtoxinA, Placebo - Platysma Prominence | Phase 3 | Completed | AbbVie | 408 | 2021-07-08 | 2024-11-20 |
| Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Migraine Botulinum toxin type A, placebo - Migraine Disorders | Phase 3 | Completed | St. Olavs Hospital | 170 | 2019-10-01 | 2026-08-11 |
| Botulinum Toxin Injections for Oral Neuropathic Pain BOTOX®, Allergan, Placebo - Trigeminal Neuropathy, Traumatic | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 43 | 2019-04-04 | 2023-04-10 |
| The Efficacy and Safety of CUNOX® in Patients With Moderate to Severe Glabellar Lines Cunox, Botox - Glabellar Frown Lines | Phase 3 | Completed | Medy-Tox | 136 | 2018-12-13 | 2020-07-29 |
| Botulinum Toxin Versus Placebo Injections to Temporalis and Masseter Muscles Botulinum toxin type A, 0.9% Sodium Chloride Injection - Pain, Head, Pain Syndrome | Phase 3 | Completed | Weill Medical College of Cornell University | 75 | 2018-08-31 | 2023-02-14 |
| Evaluate the Safety and Efficacy of Botulax® as Compared to Botox® in Subject With Moderate to Severe Crow's Feet Lines Botulinum toxin type A - Crow's Feet Lines | Phase 3 | Completed | Hugel | 240 | 2018-01-17 | 2022-04-15 |
| MEDITOXIN® in Treatment of Crow's Feet Line botulinum toxin type A - Crow's Feet Lines | Phase 3 | Completed | Medy-Tox | 250 | 2017-08-17 | 2019-03-27 |
| Early Postoperative Prevention and Treatment of Median Sternotomy Scars With Botulinum Toxin Type A Injection Botulinum toxin type A, normal saline - Scar | Phase 2 / Phase 3 | Completed | Xijing Hospital | 17 | 2016-10-01 | 2018-01-25 |
| Safety and Efficacy of NABOTA in Treatment of Essential Blepharospasm Clostridium Botulinum Toxin Type A - Blepharospasm | Phase 2 / Phase 3 | Completed | Daewoong Pharmaceutical Co. LTD. | 234 | 2016-10-01 | 2019-06-26 |
| Clinical Study to Evaluate the Efficacy and Safety of Neuronox and Botox With Essential Blepharospasm Neuronox, Botox - Essential Blepharospasm | Phase 3 | Completed | Medy-Tox | 140 | 2016-05-25 | 2017-07-13 |
| Botulinum Toxin A as a Treatment for Provoked Vestibulodynia botulinum toxin A, NaCl - Vulvodynia | Phase 3 | Completed | Karolinska Institutet | 90 | 2016-05-15 | 2019-08-15 |
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Migraine Disorders (2) · Vulvodynia (2) · Alopecia universalis (1) · Benign essential blepharospasm (1) · Blepharospasm (1) · Breast Diseases (1) · Breast Neoplasms (1) · Cicatrix (1) · Cone-Rod Dystrophies (1) · Facies (1) · Fowler Christmas Chapple syndrome (1) · Headache (1) · Hyperhidrosis (1) · Lower Extremity Deformities, Congenital (1) · Multiple Sclerosis (1)
AbbVie (8) · Medy-Tox (5) · Karolinska Institutet (2) · Weill Medical College of Cornell University (2) · Assistance Publique - Hôpitaux de Paris (1) · Azidus Brasil (1) · Catholic University of the Sacred Heart (1) · Daewoong Pharmaceutical Co. LTD. (1) · Direction Centrale du Service de Santé des Armées (1) · GlaxoSmithKline (1) · Helse Nord-Trøndelag HF (1) · Hugel (1) · Johns Hopkins University (1) · Loyola University (1) · Mayo Clinic (1)
United States (14) · Canada (5) · France (4) · South Korea (4) · China (3) · Belgium (2) · Germany (2) · Italy (2) · Norway (2) · Sweden (2) · United Kingdom (2) · Australia (1) · Brazil (1) · Bulgaria (1) · Japan (1)
Nina Bohm-Starke, MD (2) · Alexandre Frederico, Doctor (1) · Alexis Te (1) · Andrew Evans, MD (1) · Bahman Jabbari, M.D. (1) · Cindy Amundsen, MD (1) · Deborah L. Myers, MD (1) · Dennis Wallace, PhD (1) · Gwendolyn S Reeve, DMD (1) · Holly Richter, PhD, MD (1)
PMID 11743295, PMID 12893330, PMID 15291863, PMID 19568011, PMID 24486637, PMID 28426903, PMID 29031894, PMID 29141611, PMID 31211964, PMID 31895722, PMID 32769643, PMID 33620895, PMID 33721365, PMID 36307361, PMID 38228287, PMID 41727558
2014 (1), 2016 (1), 2017 (1), 2018 (1), 2019 (1), U01HD069031 (1)