40 completed, 7 terminated, 7 unknown, 4 recruiting. 63 Phase 3, 14 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized Trial of Botulinum Toxin A vs Strabismus Surgery for Esotropia >10 to ≤30PD Botulinum toxin A, bilateral medial rectus recession - Esotropia | Phase 3 | Not yet recruiting | Jaeb Center for Health Research | 244 | 2027-01-01 | 2026-04-06 |
| Evaluation of the Efficacy and Safety of Fractional CO₂ Laser With and Without Intradermal Botulinum Toxin A in the Treatment of Inflammatory Facial Acne Vulgaris. Fractional co2 laser, Botulinium Toxin-A - Acne, Acne Papulopustulosa | Phase 3 | Not yet recruiting | Cairo University | 24 | 2026-11-06 | 2026-11-05 |
| Female Sexual Dysfunction Assessment and Managment of Vaginismus Botox, Radiofrequency - Female Sexual Dysfunction | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 40 | 2025-01-01 | 2025-01-01 |
| Evaluation of Efficacy of Botulinum Toxin A Plus Oral Tadalafil 5 mg in Diabetic Men With Erectile Dysfunction Botulinum toxin A, Tadalafil 5mg - Erectile Dysfunction With Diabetes Mellitus | Phase 2 / Phase 3 | Recruiting | Aswan University Hospital | 32 | 2024-08-01 | 2024-12-03 |
| A Study to Assess BOTOX Injections for the Change of Masseter Muscle Prominence in Adult Participants BOTOX, Placebo - Masseter Muscle Prominence | Phase 3 | Completed | AbbVie | 207 | 2024-04-30 | 2026-08-12 |
| A Study to Assess BOTOX Injections in Adult Participants for the Change of Masseter Muscle Prominence BOTOX, Placebo - Masseter Muscle Prominence | Phase 3 | Completed | AbbVie | 202 | 2024-04-22 | 2026-08-25 |
| A Study to Assess the Adverse Events and Effectiveness of BOTOX Injections for the Treatment of Moderate to Severe Forehead Lines in Chinese Adult Participants BOTOX, Placebo - Forehead Lines | Phase 3 | Completed | AbbVie | 140 | 2023-12-12 | 2025-08-28 |
| A Study to Assess Adverse Events and Change of Masseter Muscle Prominence Using BOTOX Injections in Adult Participants BOTOX, Placebo for BOTOX - Masseter Muscle Prominence | Phase 3 | Completed | AbbVie | 259 | 2023-11-22 | 2026-07-06 |
| Efficacy of Extracorporeal Shock Wave Therapy in Children With Cerebral Palsy ESWT, Botulinum Toxin Type A, Serial Casting - Spasticity/Paresis, Cerebral Palsy | Phase 3 | Unknown | Kocaeli University | 40 | 2023-11-01 | 2023-11-18 |
| A Study to Assess the Effectiveness of BOTOX (Botulinum Toxin Type A) Injections for the Change of Masseter Muscle Prominence in Adult Participants BOTOX, Placebo - Masseter Muscle Prominence | Phase 3 | Completed | AbbVie | 249 | 2023-10-17 | 2025-12-10 |
| Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis Botulinum toxin, Standard-of-care corticosteroid injections - Carpometacarpal Sprain, Thumb Sprain | Phase 3 | Recruiting | Rhode Island Hospital | 50 | 2023-08-27 | 2024-11-20 |
| Examining the Effects of Intra-detrusor Botox at Time of HoLEP in Men With Overactive Bladder Symptoms OnabotulinumtoxinA - Urinary Incontinence, Overactive Bladder Syndrome | Phase 2 / Phase 3 | Active not recruiting | Northwestern University | 66 | 2023-07-13 | 2026-11-06 |
| BOTOX® vs. XEOMIN® for Chronic Migraine IncobotulinumtoxinA (XEOMIN®), OnabotulinumtoxinA (BOTOX®) - Chronic Migraine | Phase 3 | Recruiting | Naval Medical Center Camp Lejeune | 128 | 2023-02-24 | 2026-07-22 |
| Effect of Botox Injection in Anterior Belly of Digastric on Skeletal Relapse Following Mandibular Advancement Surgery Botox - Orthognathic Relapse | Phase 3 | Unknown | Cairo University | 10 | 2023-01-01 | 2022-10-12 |
| Botulinum Toxin A in Frequent and Chronic Tension-type Headache Botulinum Toxin Type A in saline water, Isotone saline water - Tension-Type Headache | Phase 3 | Completed | Helse Nord-Trøndelag HF | 66 | 2022-10-03 | 2025-03-13 |
| A Study To Assess the Safety of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence OnabotulinumtoxinA - Platysma Prominence | Phase 3 | Completed | AbbVie | 292 | 2021-11-16 | 2024-12-05 |
| Study of BOTOX Injections in Prevention of Migraine in Adult Participants With Episodic Migraine BOTOX, Placebo - Episodic Migraine | Phase 3 | Terminated | AbbVie | 775 | 2021-11-05 | 2025-12-09 |
| Study to Evaluate the Efficacy and Safety of MBA-P01 in Subjects With Glabellar Lines MBA-P01, BOTOX - Glabellar Frown Lines | Phase 3 | Completed | Medytox Korea | 318 | 2021-08-30 | 2022-06-03 |
| A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence OnabotulinumtoxinA, Placebo - Platysma Prominence | Phase 3 | Completed | AbbVie | 426 | 2021-08-10 | 2024-08-20 |
| A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Moderate to Severe Platysma Prominence OnabotulinumtoxinA, Placebo - Platysma Prominence | Phase 3 | Completed | AbbVie | 408 | 2021-07-08 | 2024-11-20 |
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Urinary Bladder, Overactive (5) · Migraine Disorders (3) · Muscle Spasticity (3) · Urinary Incontinence (3) · Urinary Incontinence, Urge (3) · Cerebral Palsy (2) · Stroke (2) · Vulvodynia (2) · Acne Vulgaris (1) · Alopecia universalis (1) · Benign essential blepharospasm (1) · Blepharospasm (1) · Botulism (1) · Brain Concussion (1) · Breast Diseases (1)
AbbVie (9) · Medy-Tox (5) · Cairo University (2) · Daewoong Pharmaceutical Co. LTD. (2) · Karolinska Institutet (2) · Mayo Clinic (2) · Weill Medical College of Cornell University (2) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Aswan University Hospital (1) · Azidus Brasil (1) · Catholic University of the Sacred Heart (1) · Daniel Stephan Engeler (1) · Direction Centrale du Service de Santé des Armées (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1)
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Nina Bohm-Starke, MD (2) · Alexandre Frederico, Doctor (1) · Alexis Te (1) · Amy Krambeck, MD (1) · Andrew Evans, MD (1) · Bahman Jabbari, M.D. (1) · Cindy Amundsen, MD (1) · Daniel S Engeler, MD (1) · Deborah L. Myers, MD (1) · Dennis Wallace, PhD (1)
PMID 11743295, PMID 12893330, PMID 15291863, PMID 18499184, PMID 19568011, PMID 24486637, PMID 26394198, PMID 26812925, PMID 27631386, PMID 28426903, PMID 29031894, PMID 29141611, PMID 31211964, PMID 31691605, PMID 31895722, PMID 32769643, PMID 33206382, PMID 33483965, PMID 33620895, PMID 33721365, PMID 34828772, PMID 35412036, PMID 36306168, PMID 36307361, PMID 36832460, PMID 38228287, PMID 41727558
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