17 completed, 4 recruiting, 4 terminated, 1 active not recruiting. 28 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 28 | Completed 17, Recruiting 4, Terminated 4, Active not recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 1 | 4 | Completed 3, Active not recruiting 1 |
Follow Belatacept: new trials by email Literature Review of Belatacept trials Research Report on Belatacept
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Belatacept in Heart Transplantation Belatacept, Tacrolimus, Mycophenolate Mofetil/Sodium - Heart Transplant | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 66 | 2025-01-29 | 2026-10-09 |
| Advancing Transplantation Outcomes in Children Sirolimus, Belatacept, Mycophenolate Mofetil - Kidney Transplant | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 200 | 2024-05-22 | 2026-10-23 |
| A Study of TCD601 in de Novo Renal Transplant Recipients TCD601, belatacept, ATG - Renal Transplantation | Phase 2 | Completed | ITB-Med LLC | 76 | 2023-12-28 | 2026-05-05 |
| Carfilzomib and Belatacept for Desensitization carfilzomib, belatacept, Bone marrow aspiration - Highly Sensitized Prospective Kidney Transplant Recipients | Phase 1 / Phase 2 | Active not recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 21 | 2021-12-28 | 2026-04-08 |
| Daratumumab and Belatacept for Desensitization daratumumab, belatacept, Bone marrow aspiration - Highly Sensitized Prospective Kidney Transplant Recipients | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 19 | 2021-11-01 | 2026-10-23 |
| Abatacept Conversion in Kidney Transplantation Belatacept, Abatacept - Renal Transplant Recipient | Phase 2 | Completed | Emory University | 87 | 2021-09-22 | 2026-09-16 |
| Belatacept in De Novo Heart Transplantation Belatacept, Tacrolimus, Mycophenolate Mofetil - Heart Transplantation | Phase 2 | Recruiting | NYU Langone Health | 12 | 2020-08-06 | 2025-12-04 |
| Belatacept Pilot Study in Lung Transplantation Immunosuppression in Lung Transplantation Belatacept, Tacrolimus, ATG - Lung Transplant Rejection, Antibody-mediated Rejection | Phase 2 | Completed | Washington University School of Medicine | 27 | 2019-12-17 | 2022-11-25 |
| Treg Modulation With CD28 and IL-6 Receptor Antagonists lulizumab pegol, antithymocyte globulin (rabbit), methylprednisolone - Living-Donor Kidney Transplant, Kidney Transplant Recipients | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 24 | 2019-12-11 | 2026-09-24 |
| A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant Belatacept, VIB4920, Thymoglobulin - Allografts, Rejection; Transplant, Kidney | Phase 2 | Completed | Amgen | 25 | 2019-10-30 | 2024-12-27 |
| Lung Transplant Plasmapheresis/Belatacept/Carfilzomib for Antibody Mediated Rejection and Desensitization Belatacept, Carfilzomib - Lung Transplant Rejection, Antibody-mediated Rejection | Phase 2 | Withdrawn | Duke University | 2019-05-01 | 2019-05-02 | |
| Regimen Optimization Study Thymoglobulin, Belatacept, mycophenolate mofetil(MMF) - Kidney Transplantation | Phase 2 | Completed | Bristol-Myers Squibb | 58 | 2015-12-31 | 2021-06-22 |
| Belatacept Conversion in Proteinuric Kidney Transplant Recipients Belatacept - Proteinuria | Phase 2 | Completed | Brigham and Women's Hospital | 15 | 2015-10-01 | 2022-11-09 |
| Immunomodulation to Optimize Vascularized Composite Allograft Integration for Limb Loss Therapy Belatacept, Hand transplant - Immunosuppression | Phase 2 | Recruiting | Linda Cendales | 50 | 2015-03-01 | 2026-04-09 |
| Open-Label Phase 2 Trial of a Steroid-Free, CNI-Free, Belatacept-Based Immunosuppressive Regimen Anti-thymocyte Globulin (Rabbit), belatacept, methylprednisolone - Primary Renal Allograft Candidate, Kidney Transplantation | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 71 | 2013-07-01 | 2026-09-24 |
| Early Conversion From CNI to Belatacept in Renal Transplant Recipients With Delayed and Slow Graft Function Belatacept, Calcineurin Inhibitor - Delayed Graft Function, Kidney Transplant | Phase 2 | Unknown | Nair, Vinay, D.O. | 90 | 2013-06-01 | 2017-01-30 |
| Pharmacokinetics, Safety and Tolerability of Single-dose Belatacept in Adolescent Kidney Transplant Recipients Belatacept - Kidney Transplant | Phase 2 | Completed | Bristol-Myers Squibb | 16 | 2013-05-09 | 2017-07-24 |
| Optimization of NULOJIX® Usage Towards Minimizing CNI Exposure in Simultaneous Pancreas and Kidney Transplantation Belatacept, methylprednisolone, Anti-thymocyte Globulin (Rabbit) - Simultaneous Kidney and Pancreas Transplantation | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 46 | 2013-02-01 | 2026-09-24 |
| Optimization of NULOJIX® Usage As A Means of Avoiding CNI and Steroids in Renal Transplantation Alemtuzumab, MMF, Basiliximab - Kidney Transplantation, Renal Transplantation | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 19 | 2011-09-01 | 2026-09-24 |
| LEA29Y (Belatacept) Emory Edmonton Protocol Allogeneic Pancreatic Islet Cells, Belatacept, Basiliximab - Type 1 Diabetes Mellitus | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 10 | 2008-10-01 | 2016-04-07 |
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Diabetes Mellitus, Type 1 (2) · Rejection, Psychology (2) · Arthritis, Rheumatoid (1) · Delayed Graft Function (1) · Hypoglycemia (1) · Proteinuria (1)
National Institute of Allergy and Infectious Diseases (NIAID) (10) · Bristol-Myers Squibb (7) · Emory University (2) · Allan D Kirk, MD, PhD (1) · Amgen (1) · Brigham and Women's Hospital (1) · Duke University (1) · ITB-Med LLC (1) · Linda Cendales (1) · NYU Langone Health (1) · Nair, Vinay, D.O. (1) · Washington University School of Medicine (1)
United States (27) · Canada (4) · Argentina (3) · Belgium (2) · France (2) · Germany (2) · Mexico (2) · Spain (2) · Australia (1) · Brazil (1) · India (1) · Ireland (1) · Italy (1) · Netherlands (1) · Poland (1)
Kenneth Newell, MD, PhD (3) · Christian P. Larsen, MD, DPhil (2) · Nicole Turgeon, MD (2) · A.M. James Shapiro, MD, PhD (1) · Annette M. Jackson, PhD (1) · Antonio Guasch, MD (1) · Christian Larsen, MD (1) · Christian P Larsen, MD, D.Phil (1) · David Briscoe, MD (1) · Eileen Chambers, MD (1) · Flavio G. Vincenti (1) · Flavio Vincenti, M.D. (1) · Flavio Vincenti, MD (1) · Fredrik Juhlin (1)
PMID 21051752, PMID 23438305, PMID 24684552, PMID 26436448, PMID 28556519, PMID 29136317, PMID 32039559, PMID 32558199, PMID 33942491, PMID 37899481, PMID 40444214, PMID 42486389
U01AI084150 (1), UM1AI109565 (1)