5 completed, 3 terminated, 2 active not recruiting, 2 unknown. 13 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 5, Terminated 3, Active not recruiting 2, Unknown 2, Withdrawn 1 |
| Phase 1 | 4 | Completed 3, Terminated 1 |
Follow Ascorbate: new trials by email Literature Review of Ascorbate trials Research Report on Ascorbate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients Ascorbate, Gemcitabine, radiation therapy - Pancreatic Neoplasm | Phase 2 | Withdrawn | Joseph J. Cullen, MD, FACS | 2025-12-31 | 2025-03-10 | |
| Vitamin C to Quality of Life in Patients With Terminal Stage Pancreatic Cancer Ascorbate - Metastatic Pancreatic Cancer, Terminal Cancer | Phase 2 | Unknown | Fudan University | 20 | 2023-08-25 | 2024-06-06 |
| Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa Vitamin C, Vitamin B1 - Sepsis, Septic Shock | Phase 2 | Unknown | Liverpool School of Tropical Medicine | 60 | 2021-09-01 | 2021-09-08 |
| High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas Ascorbate - Soft Tissue Sarcoma | Phase 1 / Phase 2 | Completed | Mohammed Milhem | 25 | 2019-06-27 | 2026-06-18 |
| A Phase 2 Trial of High-dose Ascorbate for Pancreatic Cancer (PACMAN 2.1) Gemcitabine, nab-paclitaxel, Pharmacological ascorbate - Pancreatic Neoplasms, Cancer of Pancreas | Phase 2 | Completed | University of Iowa | 40 | 2018-11-28 | 2026-07-23 |
| A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC Radiation Therapy, Paclitaxel, Carboplatin - Carcinoma, Non-Small-Cell Lung, Non-Small Cell Lung Cancer | Phase 2 | Active not recruiting | Joseph J. Cullen, MD, FACS | 43 | 2018-11-16 | 2026-07-31 |
| Gemcitabine Plus Ascorbate for Sarcoma in Adults Ascorbate, Gemcitabine - Sarcoma, Soft Tissue Sarcoma | Phase 2 | Terminated | Mohammed Milhem, MBBS | 10 | 2018-07-11 | 2020-12-10 |
| A Phase Ib Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations Vitamin C - Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | NYU Langone Health | 4 | 2018-05-01 | 2024-03-27 |
| A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme Temozolomide, radiation therapy, Ascorbic Acid - Glioblastoma Multiforme | Phase 2 | Active not recruiting | Bryan Allen | 90 | 2017-03-13 | 2026-09-30 |
| Pharmacological Ascorbate for Lung Cancer Paclitaxel, Carboplatin, Ascorbic Acid - Carcinoma, Non-Small-Cell Lung | Phase 2 | Completed | Joseph J. Cullen, MD, FACS | 55 | 2015-04-01 | 2024-08-20 |
| A Study of Vitamin C in the Treatment of Liver Cancer to Determine if it is Safe and Effective Ascorbic Acid + Sorafenib, Sorafenib - Metastatic Hepatocellular Carcinoma, Advanced Liver Cancer | Phase 1 / Phase 2 | Completed | Thomas Jefferson University | 5 | 2012-09-01 | 2025-05-04 |
| Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA Ascorbic Acid, Irinotecan - Stage IV Colorectal Cancer | Phase 1 / Phase 2 | Terminated | Thomas Jefferson University | 4 | 2011-12-01 | 2025-05-06 |
| Assessing the Efficacy and Safety of IV Vitamin C in Combination With Standard Chemotherapy for Pancreatic Ca Ascorbic Acid - Stage IV Pancreatic Cancer | Phase 2 | Terminated | Thomas Jefferson University | 11 | 2011-10-01 | 2025-05-04 |
Pancreatic Neoplasms (4) · Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (2) · Digestive System Diseases (2) · Digestive System Neoplasms (2) · Neoplasms by Site (2) · Sarcoma (2) · Acquired Immunodeficiency Syndrome (1) · Adenocarcinoma (1) · Anemia (1) · Bone Neoplasms (1) · Carcinoma, Hepatocellular (1) · Colonic Diseases (1) · Colorectal Neoplasms (1) · Endocrine Gland Neoplasms (1)
Joseph J. Cullen, MD, FACS (3) · Thomas Jefferson University (3) · Bryan Allen (1) · Fudan University (1) · Liverpool School of Tropical Medicine (1) · Mohammed Milhem (1) · Mohammed Milhem, MBBS (1) · NYU Langone Health (1) · University of Iowa (1)
United States (11) · China (1) · Uganda (1)
Daniel A Monti, MD (2) · Joseph J. Cullen, MD, FACS (2) · Bryan G. Allen, MD, PhD (1) · Daniel A Monti, MD, MBA (1) · Edith P Mitchell, MD (1) · Guopei Luo, MD (1) · Joseph Caster, MD, PhD (1) · Joseph J Cullen, MD, FACS (1) · Mohammad M Abdul Hay, MD (1) · Mohammed Milhem, MBBS (1) · Shevin T Jacob, MD MPH (1) · Varun Monga, MD (1)
PMID 28366679, PMID 35525024, PMID 37773633, PMID 39369582
P30CA086862 (3), P01CA217797 (2), U01CA140206 (2)