30 completed, 5 terminated, 5 unknown, 1 active not recruiting. 13 Not applicable, 12 Phase 4, 9 Phase 2, 9 Phase 3, 1 Early Phase 1.
Follow Artificial tears: new trials by email Literature Review of Artificial tears trials Research Report on Artificial tears
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Behavioral Intervention (Baduanjin Alone or Laughter Exercise Plus Artificial Tears) Versus Artificial Tear on Dry Eye Disease: a Randomised Controlled Trial Baduanjin, Laughter exercise, Artificial tears - Dry Eye Disease (DED) | Not applicable | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 540 | 2027-01-01 | 2026-04-13 |
| Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema Surabgene Lomparvovec, Sham, Topical Steroid - Diabetic Retinopathy | Phase 2 / Phase 3 | Recruiting | AbbVie | 576 | 2026-06-01 | 2026-10-16 |
| Effect of Rhopressa on Intraocular Pressure (IOP) in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension Post-SLT Netarsudil ophthalmic solution 0.02%, Artificial tears - Primary Open Angle Glaucoma or Ocular Hypertension | Phase 4 | Active not recruiting | East Coast Institute for Research | 70 | 2025-06-27 | 2026-06-10 |
| Topical Insulin for Ocular Surface Interface in Dry Eye Disease Artificial tear, insulin human - Dry Eye, Insulin Sensitivity | Phase 4 | Completed | Khyber Teaching Hospital | 128 | 2025-04-14 | 2026-08-14 |
| A Study to Evaluate 0.003% AR-15512 Safety and Drop Attributes 0.003% AR-15512 ophthalmic solution, Artificial tears - Dry Eye Disease | Phase 3 | Completed | Alcon Research | 55 | 2025-01-15 | 2026-03-17 |
| A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease 0.003% AR-15512 ophthalmic solution, Artificial Tears - Dry Eye Disease | Phase 3 | Completed | Alcon Research | 80 | 2024-10-08 | 2026-03-27 |
| Efficacy of Pilocarpine As a Secretagogue Versus Artificial Tears for the Treatment of Dry Eye Pilocarpine, artificial tears - Dry Eye Disease (DED) | Not applicable | Completed | Al-Azhar University | 40 | 2024-10-01 | 2024-12-30 |
| Medical vs Acupuncture for Dry Eye Artificial tears, Traditional Chinese Medicine Acupuncture - Dry Eye, Acupuncture | Not applicable | Completed | Nadide Koca | 90 | 2024-01-15 | 2025-09-22 |
| Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution NCX 470, Placebo - Open Angle Glaucoma | Phase 2 / Phase 3 | Completed | Nicox Ophthalmics, Inc. | 18 | 2023-12-12 | 2025-09-08 |
| Safety and Efficacy of Licaminlimab Ophthalmic Solution for the Treatment of Dry Eye Disease licaminlimab, vehicle of OCS-02, Artificial tears - Dry Eye Disease | Phase 2 | Completed | Oculis | 122 | 2023-11-29 | 2025-07-02 |
| Safety of Topical Insulin Drops for Open-angle Glaucoma Topical insulin (4 units), Topical insulin (20 units), Artificial tears - Glaucoma | Phase 1 | Unknown | Centre hospitalier de l'Université de Montréal (CHUM) | 18 | 2023-03-27 | 2024-08-21 |
| Diquafosol Ophthalmic Solution for Dry Eye Symptoms 3% Diquafosol tetrasodium, 0.1% hyaluronate - Diabetic Eye Problems | Not applicable | Unknown | He Eye Hospital | 101 | 2023-03-03 | 2023-01-12 |
| Diquafosol vs Hyaluronic Acid for Diabetic Dry Eye 3% Diquafosol tetrasodium, 0.1% hyaluronate - Diabetic Eye Problems | Not applicable | Completed | He Eye Hospital | 99 | 2022-12-01 | 2025-07-25 |
| Clinical Trial To Determine The Effectiveness And Safety Of Topical Insulin In Dry Eye Insulin, Cyclosporins, Artificial tears - Dry Eye, Insulin | Phase 4 | Completed | Barbara Burgos Blasco | 116 | 2022-10-19 | 2026-03-05 |
| An Observational, Qualitative Study Assessing Eye Drop Administration Artificial Tears - Ocular Injury | Unknown | Ocular Therapeutix, Inc. | 300 | 2022-04-21 | 2022-09-16 | |
| FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial Fluorometholone 0.1% Oph Susp, Artificial Tears - Trachomatous Trichiasis (TT), Eye Diseases | Phase 3 | Completed | Massachusetts Eye and Ear Infirmary | 2410 | 2021-08-19 | 2026-03-24 |
| Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP) SAF312 Placebo, SAF312 - Chronic Ocular Pain | Phase 2 | Completed | Novartis Pharmaceuticals | 153 | 2021-04-21 | 2024-10-09 |
| Effect of Artificial Tears on Radioiodine Levels in the Nasolacrimal Duct System Artificial Tears - Thyroid Carcinoma, Radioactive Iodine Level | Phase 2 | Terminated | Vanderbilt-Ingram Cancer Center | 9 | 2020-10-05 | 2024-01-18 |
| Study on Curative Effect and Mechanism of Acupuncture on Neuropathic Pain in Dry Eye Disease Sodium hyaluronate eye drops, acupuncture - Dry Eye | Not applicable | Completed | Peking University Third Hospital | 20 | 2020-09-22 | 2022-11-23 |
| Optimization of Sampling and Processing of Samples for Molecular Microbial Research on Ocular Surface Samples Conjunctival swab, Oxybuprocaine Hydrochloride 0.4% Eye Drops, artificial tears - Microbiota, Ocular Surface | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 24 | 2019-08-19 | 2022-07-22 |
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Dry Eye Syndromes (20) · Conjunctivitis (3) · Conjunctivitis, Allergic (3) · Glaucoma (3) · Pain (3) · Glaucoma, Open-Angle (2) · Insulin Resistance (2) · Keratoconjunctivitis Sicca (2) · Ocular Hypertension (2) · Adenoviridae Infections (1) · Blepharitis (1) · Conjunctivitis, Viral (1) · Corneal Diseases (1) · Corneal Injuries (1) · Diabetic Retinopathy (1)
Alcon Research (2) · He Eye Hospital (2) · Massachusetts Eye and Ear Infirmary (2) · University Hospital of Patras (2) · AbbVie (1) · Adapt Produtos Oftalmológicos Ltda. (1) · Al-Azhar University (1) · Allergan (1) · Barbara Burgos Blasco (1) · Baylor College of Medicine (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · East Coast Institute for Research (1) · Edward Holland, MD (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Greiner, Jack V., OD DO PhD (1)
United States (27) · China (3) · Greece (2) · Spain (2) · Belgium (1) · Brazil (1) · Canada (1) · Egypt (1) · Ethiopia (1) · France (1) · Japan (1) · Pakistan (1) · Puerto Rico (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Emmanuel Eric Pazo (2) · Barbara Burgos Blasco, MD, PhD (1) · Carol B Toris, PhD (1) · Constantine Georgakopoulos, MD, Phd (1) · Constantinos Georgakopoulos, MD, PhD (1) · Gail L Torkildsen, MD (1) · Gail Torkildsen, MD (1) · Heleen Delbeke, MD (1) · Jack V Greiner, OD, DO, PhD (1) · Jason Hsu, MD (1) · Jeffrey L Goldberg, MD, PhD (1) · John H Kempen, MD MPH MHS PhD (1)
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