8 completed, 5 recruiting, 3 active not recruiting, 1 terminated. 14 Phase 3, 4 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Completed 6, Recruiting 4, Active not recruiting 2, Terminated 1, Unknown 1 |
| Phase 2 | 4 | Completed 2, Active not recruiting 1, Recruiting 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow Actinomycin D: new trials by email Literature Review of Actinomycin D trials Research Report on Actinomycin D
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS) Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Rhabdomyosarcoma | Phase 3 | Recruiting | Children's Oncology Group | 342 | 2026-07-14 | 2026-08-25 |
| A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT) Bone Scan, Carboplatin, Computed Tomography - Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor | Phase 3 | Recruiting | Children's Oncology Group | 1656 | 2025-04-15 | 2026-08-25 |
| Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma Biospecimen Collection, Bone Scan, Computed Tomography - Pleuropulmonary Blastoma | Phase 3 | Recruiting | Children's Oncology Group | 110 | 2025-03-21 | 2026-08-25 |
| Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma Biopsy Procedure, Bone Scan, Computed Tomography - Embryonal Rhabdomyosarcoma, Fusion-Negative Alveolar Rhabdomyosarcoma | Phase 3 | Recruiting | Children's Oncology Group | 205 | 2022-08-04 | 2026-08-25 |
| A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Alveolar Rhabdomyosarcoma, Botryoid-Type Embryonal Rhabdomyosarcoma | Phase 3 | Active not recruiting | Children's Oncology Group | 113 | 2021-09-14 | 2026-07-30 |
| Evolutionary Therapy for Rhabdomyosarcoma Vincristine, Cyclophosphamide, Vinorelbine - Rhabdomyosarcoma | Phase 2 | Active not recruiting | H. Lee Moffitt Cancer Center and Research Institute | 12 | 2020-12-29 | 2025-11-26 |
| FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma Irinotecan, Actinomycin D, Doxorubicin - Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University of Birmingham | 1672 | 2020-09-17 | 2024-05-23 |
| Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma Cyclophosphamide, Dactinomycin, Irinotecan Hydrochloride - Alveolar Rhabdomyosarcoma, Botryoid-Type Embryonal Rhabdomyosarcoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 325 | 2016-06-01 | 2026-10-01 |
| Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Etoposide, actinomycin D, methotrexate - Gestational Trophoblastic Neoplasms | Phase 3 | Unknown | Weiguo Lv | 214 | 2016-03-01 | 2022-06-03 |
| Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Dactinomycin, Leucovorin Calcium, Methotrexate - Choriocarcinoma, FIGO Stage I Gestational Trophoblastic Tumor | Phase 3 | Completed | GOG Foundation | 57 | 2012-06-18 | 2022-08-12 |
| Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma Cixutumumab, Cyclophosphamide, Dactinomycin - Adult Rhabdomyosarcoma, Childhood Alveolar Rhabdomyosarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 175 | 2010-01-01 | 2017-08-29 |
| Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors Carboplatin, Cisplatin, Cyclophosphamide - Brain Cancer, Choroid Plexus Tumors | Phase 3 | Terminated | Tufts Medical Center | 27 | 2009-11-01 | 2019-08-20 |
| Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Dactinomycin, Doxorubicin Hydrochloride, Radiation Therapy - Adult Kidney Wilms Tumor, Beckwith-Wiedemann Syndrome | Phase 3 | Completed | Children's Oncology Group | 249 | 2009-08-24 | 2026-06-03 |
| Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor 3-Dimensional Conformal Radiation Therapy, Conventional Surgery, Cyclophosphamide - Stage III Kidney Wilms Tumor, Stage IV Kidney Wilms Tumor | Phase 3 | Completed | Children's Oncology Group | 395 | 2007-04-30 | 2026-07-24 |
| Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Cyclophosphamide, Dactinomycin, Irinotecan Hydrochloride - Adult Rhabdomyosarcoma, Childhood Alveolar Rhabdomyosarcoma | Phase 3 | Completed | Children's Oncology Group | 481 | 2006-12-26 | 2023-01-31 |
| Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection, Chest Radiography - Stage I Kidney Wilms Tumor, Stage II Kidney Wilms Tumor | Phase 3 | Completed | Children's Oncology Group | 808 | 2006-11-06 | 2026-06-03 |
| Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT filgrastim, cisplatin, cyclophosphamide - Central Nervous System Tumor, Pediatric | Phase 2 | Completed | Dana-Farber Cancer Institute | 25 | 2003-02-01 | 2015-12-24 |
| Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia Dactinomycin, Methotrexate - Good Prognosis Metastatic Gestational Trophoblastic Tumor, Hydatidiform Mole | Phase 3 | Completed | Gynecologic Oncology Group | 240 | 1999-06-01 | 2018-05-15 |
Rhabdomyosarcoma (7) · Rhabdomyosarcoma, Embryonal (3) · Sarcoma (3) · Wilms Tumor (3) · Hydatidiform Mole (2) · Rhabdomyosarcoma, Alveolar (2) · Beckwith-Wiedemann Syndrome (1) · Brain Neoplasms (1) · Central Nervous System Neoplasms (1) · Choriocarcinoma (1) · Choroid Plexus Neoplasms (1) · Gestational Trophoblastic Disease (1) · Pleuropulmonary blastoma (1) · Rhabdoid Tumor (1)
Children's Oncology Group (9) · National Cancer Institute (NCI) (2) · Dana-Farber Cancer Institute (1) · GOG Foundation (1) · Gynecologic Oncology Group (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Tufts Medical Center (1) · University of Birmingham (1) · Weiguo Lv (1)
United States (16) · Canada (12) · Australia (10) · New Zealand (10) · Puerto Rico (6) · Israel (4) · Switzerland (4) · United Kingdom (2) · Austria (1) · Belgium (1) · China (1) · Czechia (1) · Denmark (1) · France (1) · Germany (1)
Elizabeth A Mullen (3) · Abha A Gupta (1) · Christine M Heske (1) · Douglas S Hawkins (1) · Johannes Wolff, MD (1) · Jonathan Metts, MD (1) · Josephine H Haduong (1) · Julian C Schink (1) · Kris Ann P Schultz (1) · Mark W. Kieran, MD, PhD (1) · Meriel Jenney (1) · Peter F Ehrlich (1) · Raymond Osborne (1) · Suman Malempati, MD (1) · Wendy Allen-Rhoades (1)
PMID 31449468, PMID 38603649, PMID 19064966, PMID 27811504, PMID 29211618, PMID 29659330, PMID 30091945, PMID 31174239, PMID 32460997, PMID 35072864, PMID 35580298, PMID 37933882, PMID 38936378, PMID 41914453
U10CA180886 (11), U10CA098543 (5), U10CA027469 (2), 2018 (1), P30CA006516 (1), U10CA180868 (1)