50 completed, 14 unknown, 10 recruiting, 3 terminated. 64 Not applicable, 6 Phase 2, 5 Phase 1, 4 Phase 3, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ACT for Veterans With IBD and Mental Health Challenges Acceptance and Commitment Therapy - Inflammatory Bowel Diseases, Crohn's Disease | Not applicable | Not yet recruiting | VA Office of Research and Development | 50 | 2028-01-01 | 2026-02-09 |
| Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | David Bartlett, MD | 10 | 2026-06-03 | 2026-08-04 |
| Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 (IL-2) - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 10 | 2026-05-01 | 2026-04-07 |
| Internet-Delivered ACT Targeting Emotional Distress and Chronic Pain ACT - Chronic Pain | Not applicable | Recruiting | Skane University Hospital | 10 | 2026-04-01 | 2026-09-10 |
| Effectiveness of Acceptance and Commitment Therapy in Promoting Mental Health of Emerging Adults With Internet Addiction Acceptance and Commitment Therapy (ACT) - Internet Addiction | Not applicable | Completed | National University of Modern Languages | 54 | 2025-12-01 | 2026-08-13 |
| Comparing ACT, Recuperation, and ACT Plus Vocational Support for Clinical Burnout ACT, Recuperation, Vocational support - Burnout, Clinical Burnout | Not applicable | Recruiting | Uppsala University | 210 | 2025-12-01 | 2026-10-16 |
| Digital Intervention for Adults With Misophonia Acceptance and commitment therapy - Misophonia | Not applicable | Completed | Utah State University | 102 | 2025-10-16 | 2026-10-20 |
| Acceptance and Commitment Therapy for Post-Stroke Adjustment Via Telerehabilitation Acceptance and Commitment Therapy - Stroke, Psychological Flexibility | Not applicable | Completed | University of East Anglia | 5 | 2025-09-04 | 2026-08-19 |
| IMProving Outcomes With ACT After Knee Surgery Acceptance and Commitment Therapy - Total Knee Arthroplasty, Knee Osteoarthritis | Not applicable | Not yet recruiting | Belfast Health and Social Care Trust | 50 | 2025-09-01 | 2025-05-13 |
| Just ACT for Student Well-being Acceptance and Commitment Therapy - Acceptance and Commitment Therapy, Psychological Well-being | Not applicable | Recruiting | The University of Hong Kong | 96 | 2025-06-04 | 2025-08-01 |
| Acceptance and Commitment Therapy for the Improvement of Cancer Distress in Patients With Incurable Cancers, ACT-C Trial Acceptance and Commitment Therapy, Questionnaire Administration, Telemedicine - Malignant Hepatobiliary Neoplasm | Not applicable | Recruiting | Mayo Clinic | 60 | 2025-05-28 | 2026-08-04 |
| Acceptance and Commitment Therapy for HIV+ Hazardous Drinkers Acceptance and Commitment Therapy (ACT), Brief Alcohol Intervention - HIV-1-infection, Alcohol Drinking | Not applicable | Recruiting | Syracuse University | 300 | 2025-01-22 | 2026-10-20 |
| Online Therapy Youth, Equivalent to Treatment As Usual? EMDR, ACT - Depression, Trauma | Not applicable | Unknown | GGZ Noord-Holland-Noord | 172 | 2024-07-01 | 2024-09-27 |
| ACT for Syndromic and Subsyndromic Depression in Bipolar Disorder Acceptance and Commitment Therapy, Bipolar Disorder Psychoeducation Therapy - Bipolar Disorder | Not applicable | Completed | Beny Lafer | 75 | 2024-05-06 | 2026-10-02 |
| Acceptance and Commitment Therapy for Insomnia Acceptance and Commitment Therapy for insomnia (ACT-I) - Insomnia | Not applicable | Completed | University of Amsterdam | 93 | 2024-04-02 | 2026-04-17 |
| The Effect of an Online ACT Intervention on Meaning-Making Process in Cancer Patients Following Hematopoietic Cell Transplantation Acceptance and Commitment Therapy, Education - Hematopoietic Cell Transplantation Recipient, Acceptance and Commitment Therapy | Not applicable | Unknown | University of Social Sciences and Humanities, Warsaw | 192 | 2024-03-06 | 2024-05-16 |
| Effects of an ACT-based Psychological Treatment in Patients With Chronic Kidney Disease ACT - Chronic Kidney Diseases, Depression | Not applicable | Recruiting | Universidad Europea de Madrid | 104 | 2023-11-01 | 2025-04-23 |
| Psychological Treatment in Psychiatric Inpatient Care ACT - Compulsory Psychiatric Care Act, Psychosis | Not applicable | Terminated | Uppsala University | 1 | 2023-09-01 | 2023-12-20 |
| Impact of Emicizumab on Activated Clotting Time Using the i-STAT Alinity Analyzer ACT - Hemophilia A | Unknown | University Hospital, Grenoble | 15 | 2023-07-12 | 2023-08-01 | |
| Repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy Repetitive Transcranial Magnetic Stimulation, Acceptance and Commitment Therapy - Chronic Pain, Depression | Not applicable | Completed | VA Office of Research and Development | 31 | 2023-05-22 | 2026-07-17 |
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Anxiety Disorders (7) · Chronic Pain (7) · Depression (5) · Psychotic Disorders (5) · Schizophrenia (5) · Breast Neoplasms (3) · Motor Activity (3) · Obesity (3) · Psychological Well-Being (3) · Stomach Neoplasms (3) · Binge-Eating Disorder (2) · Bipolar Disorder (2) · Carcinoma, Ovarian Epithelial (2) · Colitis, Ulcerative (2) · Crohn Disease (2)
VA Office of Research and Development (5) · The Hong Kong Polytechnic University (3) · Universidad Europea de Madrid (3) · Drexel University (2) · Duke University (2) · Fred Hutchinson Cancer Center (2) · Indiana University (2) · Peking University (2) · St. Olavs Hospital (2) · University of Glasgow (2) · University of Oxford (2) · Uppsala University (2) · Utah State University (2) · Veterans Medical Research Foundation (2) · Aalborg University Hospital (1)
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Francisco Montesinos, Ph.D. (2) · Rhonda Merwin, PhD (2) · Shelley A Johns, PsyD (2) · Shuzhong Cui, M.D (2) · Zhongqiu Lin, M.D (2) · AY Loke, PhD (1) · Aleksandra Kroemeke, PhD (1) · Amod Sarnaik, M.D. (1) · Andrew T Gloster, Prof. Dr. (1) · Anu Kangasniemi, M.Sc. (1) · Ariel J Lang, PhD (1) · Arjen Dondorp, MD (1) · Asia Mushtaq, PhD (1) · Beny Lafer, MD PhD (1)
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