4 completed. 4 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 4 |
| Phase 2 | 4 | Completed 4 |
Follow 5,10-methylenetetrahydrofolic acid: new trials by email Literature Review of 5,10-methylenetetrahydrofolic acid trials Research Report on 5,10-methylenetetrahydrofolic acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Modufolin (Arfolitixorin) in Combination With 5-Fluorouracil Alone or Together With Oxaliplatin or Irinotecan in Colorectal Cancer Modufolin (arfolitixorin), Fluorouracil, Oxaliplatin - Colorectal Neoplasm | Phase 1 / Phase 2 | Completed | Isofol Medical AB | 105 | 2014-09-01 | 2020-09-09 |
| Investigation of [6R] 5,10-methylenetetrahydrofolate (Arfolitixorin) as Rescue Therapy for Osteosarcoma Patients Treated With HDMTX. Calcium Folinate, [6R] 5,10-methylenetetrahydrofolate (arfolitixorin) - Osteosarcoma | Phase 1 / Phase 2 | Completed | Isofol Medical AB | 18 | 2013-12-01 | 2020-09-25 |
| PK/PD Investigation of Modufolin (Arfolitixorin) in Plasma, Tumor and Adjacent Mucosa Adjacent Mucosa in Patients With Colon Cancer 6R-MTHF (arfolitixorin) 200 mg/m2, Levoleucovorin 200 mg/m2, 6R-MTHF (arfolitixorin) 60 mg/m2 - Colonic Neoplasms | Phase 1 / Phase 2 | Completed | Isofol Medical AB | 32 | 2012-09-01 | 2020-09-25 |
| An Extended Feasibility Phase I/II Study of Methylenetetrahydrofolate (Arfolitixorin) and Pemetrexed Single Agent, Given as Neoadjuvant Treatment in Patients With Resectable Rectal Cancer [6R] 5,10-methylenetetrahydrofolate (arfolitixorin), Pemetrexed - Rectal Cancer | Phase 1 / Phase 2 | Completed | Isofol Medical AB | 24 | 2011-04-14 | 2020-09-09 |
Colorectal Neoplasms (3) · Gastrointestinal Diseases (3) · Gastrointestinal Neoplasms (3) · Intestinal Neoplasms (3) · Digestive System Neoplasms (2) · Rectal Neoplasms (2) · Colonic Neoplasms (1) · Digestive System Diseases (1) · Intestinal Diseases (1) · Neoplasms (1) · Neoplasms by Site (1) · Osteosarcoma (1) · Rectal Diseases (1)
Sweden (4) · Czechia (1) · Denmark (1) · Greece (1) · Hungary (1) · Norway (1) · Poland (1)
Bengt G Gustavsson, PhD, MD (1) · Kristoffer Derwinger, MD PhD (1) · Mikael Eriksson, MD PhD (1)
2014 (1)