Clinical Comparative Evaluation of the Use of Photodynamic Therapy in Conjunction With the Use of Vitamin D in Management Stage II Grade B Periodontitis Patients: A Randomized Controlled Clinical Trial.
| Registry | NCT06700122 |
|---|---|
| Status | Completed |
| Phase | Not applicable |
| Study type | Interventional; randomized, parallel, masking: double, treatment |
| Enrollment | 24 (Actual) |
| Sponsor | Cairo University (Other) |
| Conditions | Vitamin D Deficiency |
| Interventions | non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D (Dietary supplement) |
| Dates | start 2025-03-01, primary completion 2025-05-01, completion 2025-05-01, first posted 2024-11-21, last updated 2026-05-26 |
| Locations | 1 site in Egypt |
Related Papers Related Patents Related Grants Related Experts
All trials for Vitamin D Deficiency All trials of non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D
Clinical Comparative Evaluation of the use of Photodynamic Therapy in conjunction with the use of Vitamin D in management Stage II Grade B Periodontitis Patients: A Randomized controlled clinical trial.
This randomized clinical trial evaluates the effect of Photodynamic therapy alone with SRP versus Photodynamic therapy with SRP and Vitamin D regarding Clinical evaluation
1. Clinical attachment loss (CAL)
2. Probing pocket depth (PPD)
3. Bleeding on probing (BOP)
| Arm | Type | Interventions | Description |
|---|---|---|---|
| non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) only | Active comparator | Dietary Supplement: non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D | * all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler and a manual universal curette where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more will be done to preserve any residual fibers attached and to avoid unintentional curettage and prevent any possible shrinkage. * Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage. * All teeth will be polished with a rubber cup. Photodynamic therapy will be done with a blue halogen curing light of wavelength 470 nm with intensity 620 mW/cm2, a continuous mode for 5 min. * The photosensitizer will be applied to the bottom of the periodontal pocket with the help of an applicator. After 5 min, the photosensitizer will be rinsed with saline and will be exposed to on blue halogen curing light "0" day, which will be repeated on 7th and 21st day. |
| non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D | Experimental | Dietary Supplement: non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D | * all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler and a manual universal curette where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more will be done * Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage. * All teeth will be polished with a rubber cup. Photodynamic therapy will be done with a blue halogen curing light of wavelength 470 nm with intensity 620 mW/cm2, a continuous mode for 5 min. * The photosensitizer will be applied to the bottom of the periodontal pocket with the help of an applicator. After 5 min, the photosensitizer will be rinsed with saline and will be exposed to on blue halogen curing light "0" day, which will be repeated on 7th and 21st day. Serum vitamin D levels will be assessed by blood sample at baseline and 6 weeks after intervention in test group. |
Sex: All, ages: 18 Years to 50 Years, accepts healthy volunteers
Inclusion Criteria: * Systemic healthy patients * Patients aged > 25 years * Patients suffering from stage II periodontitis with grade B were included in this study, according to 2017 world workshop classification of periodontal disease. * Patients with interdental clinical attachment loss (CAL) of 3-4 mm with radiographic evidence of bone loss extending to coronal third of the root. * Radiographic bone loss (RBL) will be diagnosed using periapical parallel technique using 6 radiographic images for full mouth (3- radiographic images for maxillary arch and 3- radiographic images for mandibular arch) including anterior, canine region and posterior teeth at baseline for diagnosis. * No history of previous periodontal therapy. * No taken medications known to interfere healing or periodontal tissue health such as anticonvulsants, calcium channel blockers, or immunosuppressant drugs. * No previous periodontal surgery at involved sites. * Good oral hygiene and good compliance with the plaque control instructions following initial therapy. * Neither taken antibiotics within the last three months nor nonsteroidal anti-inflammatory drugs within the last three months * Absence of diseases or conditions that would interfere with wound healing such as diabetes mellitus or coagulation disorders Exclusion Criteria: Patients taking Vitamin D as a nutritional supplement were excluded from the study * Smoking habits * Pregnant and lactating mothers * Patients who have been received periodontal surgery in the study area during the last 6 months.
| Facility | City | Country | Status |
|---|---|---|---|
| Marwa Helal | Cairo | Egypt |