19 completed, 4 terminated, 2 recruiting, 1 not yet recruiting. 13 Phase 2, 6 Phase 3, 5 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 10, Terminated 3 |
| Phase 3 | 6 | Completed 6 |
| Phase 1 | 5 | Completed 4, Terminated 1 |
| Phase 4 | 1 | Not yet recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Exploration of Novel AI-enabled Blue Light Enhanced Cystoscopy Bladder Cancer, Non-muscle Invasive Bladder Cancer | Recruiting | Photocure | 500 | 2026-03-25 | 2026-10-29 | |
| The Impact of PDD During TURB for NMIBC Transurethral resection of the bladder performed with PDD tecnique and Hexvix - Bladder Cancer | Phase 4 | Not yet recruiting | A.O.U. Città della Salute e della Scienza | 300 | 2024-09-01 | 2024-08-12 |
| Comparative Study of Hexvix Blue Light Cystoscopy and White Light Cystoscopy in the Detection of Bladder Cancer Hexaminolevulinate Hydrochloride, Richard Wolf Photodynamic Diagnostic Equipment (PDD) system - Bladder Cancer | Phase 3 | Completed | Photocure | 158 | 2022-11-03 | 2024-10-03 |
| RESECT: Improving Quality in TURBT Surgery. Performance feedback and education - Bladder Cancer | Completed | British Urology Researchers in Surgical Training | 19505 | 2021-04-19 | 2023-11-14 | |
| A Study of Blue Light Flexible Cystoscopy With Cysview in the Detection of Bladder Cancer in the Surveillance Setting Hexaminolevulinate hydrochloride, KARL STORZ D-Light C PDD Flexible Videoscope System - Bladder Cancer | Phase 3 | Completed | Photocure | 304 | 2015-10-01 | 2018-07-02 |
| Blue Light Cystoscopy With Cysview® Registry Hexaminolevulinate hydrochloride (HCL), Karl Storz D-Light C Photodynamic Diagnostic (PDD) system - Bladder Cancer | Recruiting | Photocure | 4400 | 2014-04-01 | 2025-12-18 | |
| Detection of Bladder Tumors After 30 Min Instillation of Hexvix Hexvix - Bladder Cancer | Phase 2 | Terminated | Photocure | 38 | 2011-12-01 | 2012-10-25 |
| Treatment of Female Genital Erosive Lichen Planus(GELP) With Hexaminolevulinate PDT clobetasol propionate 0,05% ointment, hexaminolevulinate - Genital Lichen Planus | Phase 2 / Phase 3 | Completed | Oslo University Hospital | 40 | 2011-08-01 | 2021-03-17 |
| A Double Blinded, Prospective, Randomized, Vehicle Controlled Multi-center Study of Photodynamic Therapy With Visonac® Cream in Patients With Acne Vulgaris Visonac PDT, Vehicle cream with PDT - Acne Vulgaris | Phase 2 | Completed | Photocure | 153 | 2011-05-01 | 2014-01-16 |
| Dose-finding Study of Hexaminolevulinate (HAL) Photodynamic Therapy (PDT) to Treat Cervical Neoplasia HAL 5% with illumination, HAL 1% with illumination, HAL 0.2% with illumination - Cervical Intraepithelial Neoplasia | Phase 2 | Completed | Photocure | 262 | 2011-04-01 | 2016-05-16 |
| Photoactive Porphyrins (PAP) Levels After Topical Visonac Application in Acne Patients Area cleaned with saline water and occluded with Tegaderm, Area cleaned with saline water, Area cleaned with Ethyl alcohol solution - Acne Vulgaris | Phase 2 | Completed | Photocure | 20 | 2010-08-01 | 2014-05-20 |
| Longer-term Recurrence Rates in Patients With Bladder Cancer After Hexvix (Cysview)Fluorescence Cystoscopy/TURB Bladder Cancer | Completed | Photocure | 551 | 2010-06-01 | 2019-04-09 | |
| An Open-label, Single-dose, Three Period Study to Determine the Pharmacokinetic Parameters of Hexaminolevulinate (HAL) Hydrochloride After Vaginal, Enema and Intravenous Administration of Healthy Female Volunteers hexaminolevulinate (HAL) - Pharmacokinetics | Phase 1 | Completed | Photocure | 8 | 2009-11-01 | 2010-01-15 |
| Efficacy and Safety Study With Visonac Photodynamic Therapy (PDT) Visonac PDT (MAL PDT), Vehicle cream (placebo), PDT - Acne Vulgaris | Phase 2 | Completed | Photocure | 107 | 2009-08-01 | 2013-12-11 |
| An Open Dose-finding Study of Oral Applied Hexaminolevulinate (HAL) Imaging in Patients With Suspicion or High Risk of Neoplasia in the Colon hexaminolevulinate HCl - Colon Cancer | Phase 1 / Phase 2 | Terminated | Photocure | 13 | 2009-02-01 | 2013-10-23 |
| Hexaminolevulinate (HAL) Photodynamic Therapy (PDT) of Cervical Intraepithelial Neoplasia (CIN) Grade 1 Hexaminolevulinate (HAL), Placebo - Cervical Intraepithelial Neoplasia | Phase 2 | Terminated | Photocure | 83 | 2009-01-01 | 2013-04-24 |
| Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Patients With Skin Type V or IV With Acne Vulgaris Methyl aminolevulinate (MAL) PDT - Acne Vulgaris | Phase 2 | Completed | Photocure | 20 | 2008-05-01 | 2013-07-12 |
| Safety and Efficacy Study of Topical Methyaminlevulinate (MAL) in Subjects With Facial Acne MAL - Acne | Phase 2 | Completed | Photocure | 44 | 2007-07-01 | 2009-01-30 |
| Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Moderate to Severe Acne Methyl aminolevulinate (MAL) PDT - Acne Vulgaris | Phase 2 | Completed | Photocure | 150 | 2007-02-01 | 2013-08-08 |
| A Dose-finding Study of MAL and HAL Photodynamic Therapy of Cervical Premalignant Lesions. methyl aminolevulinate (MAL) and hexaminolevulinate (HAL) - Cervical Dysplasia | Phase 1 / Phase 2 | Completed | Photocure | 96 | 2006-08-01 | 2010-11-30 |
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Urinary Bladder Neoplasms (11) · Acne Vulgaris (6) · Non-Muscle Invasive Bladder Neoplasms (4) · Uterine Cervical Dysplasia (3) · Carcinoma, Transitional Cell (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1)
5-aminolevulinic acid hexyl ester (14) · 1-phenyl-3,3-dimethyltriazene (4) · methyl 5-aminolevulinate (3) · Drug Delivery Systems (2) · Red Light (2) · Biopsy (1) · Clobetasol (1) · Cystoscopy (1) · Educational Status (1) · Ethanol (1) · Lighting (1) · Ointments (1) · Salicylic Acid (1) · Saline Waters (1) · Solutions (1)
United States (11) · Germany (9) · Norway (6) · Canada (5) · Netherlands (3) · Austria (2) · Belgium (1) · China (1) · Denmark (1) · France (1) · United Kingdom (1)
David Pariser, MD (2) · Peter Hillemanns, MD, PhD (2) · Alexander Karl, MD (1) · Ashish C Bhatia, MD (1) · Berit Nicolaisen, M.Sc. (1) · Brigitte Mayinger, MD, PhD (1) · Dirk Zaak, MD (1) · Francesco Soria (1) · Gregers G Hermann, MD, DM Sci (1) · H Barton Grossman (1) · Herbert Barton Grossman, MD (1) · J. Stephen Jones, MD (1) · Lawrence F. Eichenfield, M.D (1) · Li Han Zhong, BMed (1)
PMID 29203268, PMID 18197583, PMID 20850152, PMID 21414125, PMID 25467012, PMID 29859728, PMID 29979488, PMID 34053856, PMID 34637596, PMID 34694916, PMID 35750559, PMID 36435710, PMID 37318875, PMID 38610946, PMID 39284074, PMID 41919786, PMID 42744708