12 completed, 5 not yet recruiting, 4 active not recruiting, 3 unknown. 20 Not applicable, 2 Phase 1, 2 Phase 2, 1 Phase 4.
Follow White Spot Lesions: new trials by email Literature Review of White Spot Lesions trials Research Report on White Spot Lesions
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of BG Versus RI on the Depth of WSL Bioactive Glass (NovaMin), Resin Infiltration (ICON), Fluoride Toothpaste - White Spot Lesions | Not applicable | Not yet recruiting | Riphah International University | 90 | 2026-09-01 | 2026-08-18 |
| Preventive Potential of Fluoride Sealants in Adolescent Orthodontic Patients Use of a bonding agent to place the orthodontic appliance, Use of fluoride releasing bonding agent to place the orthodontic appliance - White Spot Lesions | Not yet recruiting | Sigmund Freud PrivatUniversitat | 40 | 2026-09-01 | 2026-07-09 | |
| QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment Dental Caries, White Spot Lesions | Not yet recruiting | Universidad El Bosque, Bogotá | 30 | 2026-07-21 | 2026-05-27 | |
| A Novel Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding Remineralizing self-etch primer (M-SEP, SEP 1), Standard self-etch primer (P-SEP, SEP 2) - White Spot Lesions, Enamel Demineralization | Not applicable | Not yet recruiting | University of Baghdad | 45 | 2026-05-15 | 2026-05-07 |
| PATIENT SATISFACTION AND MASKING OF WHITE SPOT LESIONS AFTER HOME WHITENING WITH 10% CARBAMIDE PEROXIDE Whitening treatment with 10% carbamide peroxide on teeth with white spot lesions - White Spot Lesions | Not applicable | Enrolling by invitation | Universidad Rey Juan Carlos | 67 | 2025-10-27 | 2025-11-25 |
| The Effect of Nano Chitosan Surface Coating on White Spot Lesions Development in Clear Aligner Therapy Patients chitosan nanoparticles, No Treatment Added - White Spot Lesions | Not applicable | Active not recruiting | Jordan University of Science and Technology | 53 | 2025-10-12 | 2026-07-20 |
| Evaluate the Effect of Fluoride-Releasing Composite Resin on Prevention of White Spot Lesions During Clear Aligner Therapy Application of fluoride-releasing composite, Application of conventional composite - White Spot Lesions, Clear Aligner Appliance | Not applicable | Active not recruiting | Mansoura University | 24 | 2025-08-01 | 2026-02-23 |
| AI-Generated WhatsApp Reminders vs. No Reminders: Impact on Oral Health in Young Adults Health education followed by AI-generated Whatsapp reminders, Oral Health Education - White Spot Lesions, Dental Plaque | Not applicable | Not yet recruiting | Cairo University | 60 | 2025-05-01 | 2025-04-02 |
| Remineralization Capacity and Patient Satisfaction of Self-Assembling Peptide With Fluoride Versus Tooth Protective Coating With Surface Pre-Reacted Glass on White Spot Lesions self-assembling peptide, S-PRG Barrier Coat - White Spot Lesions | Not applicable | Completed | Nahda University | 44 | 2025-02-16 | 2025-11-26 |
| Effect of Nanohydroxyapatite Paste After Different Pretreatment Techniques on White Spot White Spot Lesions Nanohydroxyapatite paste, HCl liquid, microabrasion - White Spot Lesions | Not applicable | Completed | National Research Centre, Egypt | 40 | 2024-12-05 | 2025-02-24 |
| Silver Nanoparticle-Coated Orthodontic Brackets for Preventing Enamel Demineralization Silver Nanoparticle-Coated Stainless Steel Orthodontic Brackets, Conventional Stainless Steel Orthodontic Brackets - Enamel Demineralization, White Spot Lesions | Not applicable | Completed | Ajman University | 16 | 2024-09-20 | 2026-07-16 |
| Topical 10% Povidone-Iodine in Preventing White Spots Placebo, Povidone-iodine solution - White Spot Lesions, Gingival Inflammation and Bleeding | Phase 2 | Active not recruiting | University of Washington | 80 | 2024-09-13 | 2026-07-16 |
| Assessing the Effects of Resin Infiltration and Resin Modified Glass Ionomer on the Color Changes of White Spot Lesions in a Clinical and Laboratory Setting Resin infiltration, Vanish XT varnish (resin modified glass ionomer restoration) - White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth | Phase 4 | Active not recruiting | King Abdulaziz University | 60 | 2024-08-20 | 2024-11-21 |
| Comparative Effectiveness of Remineralization Agents on Attachment-Associated Demineralization in Clear Aligner Patients GC Tooth Mousse, Nano-Hydroxyapatite Gel, Sodium Fluoride varnish - White Spot Lesions, Demineralization | Not applicable | Completed | Bezmialem Vakif University | 40 | 2024-08-12 | 2025-11-14 |
| "Clinical Evaluation of Self-Assembling Peptides Versus Tri-Calcium Phosphate Based Varnish in Treatment of White Spot Lesions; Split-Mouth Randomized Clinical Trial" Curodont Repair (SAP P11-4), Clinpro White Varnish (Tri-Calcium Phosphate, TCP) - White Spot Lesions | Not applicable | Enrolling by invitation | Ain Shams University | 38 | 2024-02-20 | 2025-12-17 |
| Labial White Spot Lesions and Proximal Caries Development in Orthodontic Patients Using Clear Aligners Versus Traditional Braces. Fixed pre-adjusted edgewise orthodontic appliance, Clear aligner therapy - White Spot Lesions, Proximal Caries | Not applicable | Completed | University of Sharjah | 24 | 2024-01-08 | 2026-04-30 |
| Prevention of White Spot Lesions Using Bioactive Gel giomer based bioactive gel, Fluoride gel - White Spot Lesions | Phase 1 | Unknown | Cairo University | 330 | 2023-08-01 | 2023-07-17 |
| Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment Resin infiltration, Casein Phosphopeptide (CPP) - Amorphous Calcium Phosphate (ACP) - Fluoride - White Spot Lesions, Orthodontic Appliance Complication | Not applicable | Recruiting | University of Alberta | 62 | 2023-05-30 | 2026-06-30 |
| Effect of the Use of Self-Assembling Peptides Versus Resin Infiltration on Post Orthodontic White Spot Lesions: A Randomized Clinical Trial Self-Assembling Peptide (Curodont Repair) - White Spot Lesions | Phase 1 | Completed | Suez Canal University | 42 | 2023-04-10 | 2026-08-19 |
| Clinical Evaluation of White Spot Lesions Treated by S-PRG Material and Composite Sealants in Comparison With ICON surface pre-reacted glass filler coating material - White Spot Lesions | Not applicable | Completed | Al-Azhar University | 20 | 2020-01-20 | 2022-10-04 |
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Dental Caries (2) · Dental Enamel Hypomineralization (1) · Dental Plaque (1) · Gingivitis (1) · Heart Arrest (1) · Hemorrhage (1) · Hypersensitivity (1) · Personal Satisfaction (1)
Stomatognathic Diseases (5) · Tooth Diseases (4) · Tooth Demineralization (2) · Behavior (1) · Cardiovascular Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Dental Deposits (1) · Developmental Defects of Enamel (1) · Gingival Diseases (1) · Heart Diseases (1) · Immune System Diseases (1) · Infections (1) · Mouth Diseases (1) · Pathologic Processes (1)
Bifluorid 12 (1) · Enamel Microabrasion (1) · Fluorides (1) · Health Education, Dental (1) · Hydrochloric Acid (1) · NovaMin (1) · Orthodontic Appliances, Fixed (1) · ginger extract (1) · splicing factor 3a (1) · tenocyclidine (1)
Cairo University (4) · Ain Shams University (1) · Ajman University (1) · Al-Azhar University (1) · Bezmialem Vakif University (1) · Ege University (1) · Jordan University of Science and Technology (1) · King Abdulaziz University (1) · Mansoura University (1) · Medical University of Sofia (1) · Medical University of Warsaw (1) · Nahda University (1) · National Research Centre, Egypt (1) · Riphah International University (1) · Sigmund Freud PrivatUniversitat (1)
Egypt (7) · Turkey (Türkiye) (2) · United Arab Emirates (2) · United States (2) · Bulgaria (1) · Canada (1) · Iraq (1) · Jordan (1) · Pakistan (1) · Poland (1) · Saudi Arabia (1) · Spain (1) · United Kingdom (1)
Ahmed Elkhadem, PhD (1) · Alexander B Bonchev, Chief Assistant Professor (1) · David Bearn, M(Orth)RCS PhD BDS (1) · Dorota Olczak-Kowalczyk, Ass. Prof. (1) · Dorota Olczak-Kowalczyk, Ass.Prof. (1) · Ece Eden (1) · Ecem Ergin (1) · Franklin Garcia-Godoy, DDS, MS (1) · Greg Huang, DMD, MSD, MPH (1) · Ida M Kornerup, DMD, MEd (1) · Jeny M George, MDS (1) · Khalid Noman, PROF (1) · Louise Greene, MFDS BDS (1) · Michael H Bertl, Professor (1)
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