11 completed, 11 unknown, 6 not yet recruiting, 2 active not recruiting. 20 Not applicable, 3 Phase 2, 3 Phase 3, 2 Early Phase 1, 2 Phase 4.
Follow White Spot Lesion of Tooth: new trials by email Literature Review of White Spot Lesion of Tooth trials Research Report on White Spot Lesion of Tooth
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Artificial Intelligence Versus Clinical Examination in White Spot Lesions Detection, Identification, And Scoring Artificial Intelligence models (YOLO and MASK-RCNN) - White Spot Lesion of Tooth | Not yet recruiting | Cairo University | 329 | 2026-12-01 | 2026-10-21 | |
| S-PRG Filler for Preventing White Spot Lesions During Orthodontic Treatment S-PRG Barrier Coat, S-PRG Barrier Coat + 5% Sodium Fluoride Varnish, 5% sodium fluoride varnish - White Spot Lesion of Tooth, Orthodontic Treatment | Not applicable | Not yet recruiting | National University of Malaysia | 144 | 2026-10-01 | 2026-09-24 |
| Clinical Outcomes, Cost-Effectiveness and Patient Satisfaction of Two Resin Infiltration Systems for The Management of White Spot Lesions light cured low viscosity resin infiltration - White Spot Lesion of Tooth | Not applicable | Not yet recruiting | Cairo University | 50 | 2026-08-29 | 2026-09-02 |
| A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive Etch-Free Adhesive, Conventional Etch-and-Bond Adhesive - Bracket Bonding, Orthodontic Treatment | Not applicable | Recruiting | University of Maryland, Baltimore | 20 | 2025-11-05 | 2025-11-10 |
| Color Stability of S-PRG Resin-Based Light-Cure Varnish and Prophylaxis Paste on White Spot Lesions S-PRG Barrier coat, S-PRG Prophylaxis paste - White Spot Lesion of Tooth | Not applicable | Not yet recruiting | Cairo University | 58 | 2025-09-21 | 2025-08-17 |
| Remineralization Potential of PRG Barrier Coat Versus Fluoride Varnish in White Spot Lesions in Permanent Anterior Teeth of Children 5% NaF fluoride varnish, PRG Barrier coat - White Spot Lesion of Tooth, Demineralization | Not applicable | Not yet recruiting | Cairo University | 78 | 2025-09-01 | 2025-05-28 |
| Effect of Bioactive Resin Material Containing S-PRG Filler on White Spot Lesions Bioactive resin composite containing S-PRG filler, Conventional flowable composite is used for the attachments for the clear orthodontic aligners - White Spot Lesion of Tooth | Not applicable | Active not recruiting | Jordan University of Science and Technology | 50 | 2025-07-13 | 2026-07-21 |
| Impact of Lingual Attachment on WSL Development in Clear Aligner Patients: A Randomized Controlled Clinical Trial Lingual attachment participants - White Spot Lesion of Tooth | Not applicable | Active not recruiting | Jordan University of Science and Technology | 52 | 2025-02-02 | 2026-03-31 |
| Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries Silver diamine fluoride- potassium iodide, Fluoride varnish, 0.9 % saline - Demineralization, Tooth, White Spot Lesion of Tooth | Phase 2 | Not yet recruiting | National University of Malaysia | 99 | 2025-01-31 | 2025-01-30 |
| Effect of Different Remineralizing Agents on White Spot Lesions Treatment in Children Casein phosphopeptide-amorphous calcium phosphate, Casein phosphopeptide-amorphous calcium phosphate + fluoride, Nano hydroxyapatite paste - White Spot Lesion of Tooth | Not applicable | Completed | National Research Centre, Egypt | 100 | 2024-12-01 | 2025-02-12 |
| Clinical Evaluation of Remineralizing Potential of Remineralizing Agents on WSLs Managment SAP fluoride plus, 10% n-HAp., 10% n-BAG. - Initial Dental Caries, White Spot Lesion of Tooth | Not applicable | Unknown | Mansoura University | 120 | 2024-09-10 | 2025-08-13 |
| Remineralizing Effect of Different Silver-containing Agents on Initial Caries Lesions in Primary Teeth in Children NSF, SDF+KI, Control group - White Spot Lesion of Tooth | Early Phase 1 | Unknown | Plovdiv Medical University | 30 | 2024-07-29 | 2024-07-05 |
| Efficacy of Different Agents in Treatment of Initial Caries on Smooth Surfaces in Permanent Teeth in Children Self-assembling peptide (P11-4), CPP-ACFP, Resin infiltration - White Spot Lesion of Tooth | Phase 3 | Unknown | Plovdiv Medical University | 40 | 2024-06-01 | 2024-05-09 |
| Toothpastes With Different Contents and Tooth Color Colgate use, Curaprox use, ROCS use - White Spot Lesion of Tooth, Tooth Color | Completed | Taner OZTURK, DDS, MS | 45 | 2024-05-01 | 2025-09-19 | |
| EFFECTIVENESS of WATER FLOSS in PLAQUE REMOVAL and PREVENTION of WHITE SPOT LESIONS in ORTHODONTIC PATIENTS: a RANDOMISED CONTROLLED CLINICAL TRIAL water flosser - White Spot Lesion of Tooth, Gingival Inflammation | Not applicable | Unknown | University of Malaya | 32 | 2024-04-01 | 2024-12-30 |
| Color Masking Potential of Bioactive and ICON Materials Icon Infiltrant, Bioactive infiltrant - White Spot Lesion of Tooth | Not applicable | Unknown | King Abdullah University Hospital | 75 | 2023-12-01 | 2024-05-07 |
| Remineralization Agents for the Treatment of White Spot Lesions Clinpro® 5% sodium fluoride plus tri calcium phosphate varnish, Tooth Mousse® - Casein phosphopeptide-Amorphous calcium phosphate (CPP - ACP)s, MI Paste® -Casein phosphopeptide-Amorphous calcium phosphate fluoride (CPP-ACPF) - White Spot Lesion of Tooth | Not applicable | Terminated | Ministry of Health, Bahrain | 12 | 2022-09-01 | 2023-11-09 |
| Combined Application of Diode Laser and Different Remineralizing Agents on White Spot Lesions Remin Pro, X Pur Remin, Fluoride varnish - White Spot Lesion of Tooth | Not applicable | Completed | Al-Azhar University | 45 | 2022-05-05 | 2023-05-24 |
| Effect of Diode Laser With Dye and Remineralizing Agent on Surface Area of White Spot Lesions by Using Digital Subtraction Radiograph Techniques. remin pro - White Spot Lesion of Tooth | Not applicable | Completed | Al-Azhar University | 90 | 2022-05-05 | 2026-09-14 |
| Incidence of White Spot Lesions Around Ceramic Brackets Compared With Metal Brackets Orthodontic fixed appliance therapy - White Spot Lesion of Tooth | Not applicable | Completed | Jordan University of Science and Technology | 51 | 2021-12-28 | 2025-07-11 |
Showing 20 of 32. Sign in to see all of them.
Dental Caries (1) · Dental Plaque (1) · Gingival Hemorrhage (1) · Gingivitis (1) · Long Term Adverse Effects (1) · Tooth Demineralization (1)
Stomatognathic Diseases (3) · Tooth Diseases (3) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Dental Deposits (1) · Gingival Diseases (1) · Hemorrhage (1) · Infections (1) · Mouth Diseases (1) · Oral Hemorrhage (1) · Periodontal Diseases (1) · Tooth Demineralization (1)
casein phosphopeptide-amorphous calcium phosphate nanocomplex (6) · Control Groups (3) · Fluorides (2) · NovaMin (1) · P11-4 peptide (1) · PRG Barrier Coat (1) · Quantitative Light-Induced Fluorescence (1) · Sodium Chloride (1) · Sodium Fluoride (1) · Sondhi Indirect Bonding Resin (1) · icon infiltrant (1) · pearl powder (1) · silver diamine fluoride (1)
Cairo University (6) · Jordan University of Science and Technology (4) · Al-Azhar University (2) · National Research Centre, Egypt (2) · National University of Malaysia (2) · Plovdiv Medical University (2) · King Abdullah University Hospital (1) · Mansoura University (1) · Ministry of Health, Bahrain (1) · Mohamed zidan (1) · Peoples University, Bhanpur, Bhopal (1) · Pomeranian Medical University Szczecin (1) · Raneen Ahmed (1) · Rania Salah (1) · Ruba Alaa El Din Adel El Damarisy (1)
Egypt (10) · Jordan (5) · Malaysia (3) · Bulgaria (2) · Bahrain (1) · India (1) · Iraq (1) · Turkey (Türkiye) (1) · United States (1)
Ahmad Shuhud Irfani Zakaria, MClinDent (1) · Ani Belcheva, PhD (1) · Antonia Palankalieva, DMD (1) · Asmaa A. Elsayed Osman (1) · Asmaa A. Mohamed Yassen (1) · Dr.Chandrika Dubey, MDS (1) · Hala M. Abbas, PhD (1) · Katarzyna Grocholewicz, DDS, PhD (1) · Lamiaa M Moharam, Assoc Prof. (1) · Mohamed F Rashed, Researcher (1) · Ola Al-Batayneh, MDSc, FRACDS (1) · Rawda Hesham Abdelaziz (1) · Ruba A El Damarisy, MDS (1) · Susan Al-Khateeb (1) · Susan Al-Khateeb, Professor (1)
PMID 21208070, PMID 6758594, PMID 11455374, PMID 15562583, PMID 1590288, PMID 17693365, PMID 17827963, PMID 20691346, PMID 20691360, PMID 22381494, PMID 22565510, PMID 26926020, PMID 27030284, PMID 27871699, PMID 27907894, PMID 28566845, PMID 28580541, PMID 30007454, PMID 30957083, PMID 31217917, PMID 31375814, PMID 3164585, PMID 32337230, PMID 33057826, PMID 33348756, PMID 33459095, PMID 35978074, PMID 36049047, PMID 40830200, PMID 41068748, PMID 6589736