18 completed, 1 recruiting, 1 unknown. 6 Phase 2, 5 Not applicable, 2 Phase 1, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 6 |
| Not applicable | 5 | Completed 4, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
Follow Wasting Syndrome: new trials by email Literature Review of Wasting Syndrome trials Research Report on Wasting Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Laser Height Measuring Device Study in Vietnam Laser Height/Length Measuring Device, ShorrBoard - Child Malnutrition, Wasting Syndrome | Completed | World Vision US | 571 | 2025-05-28 | 2026-10-30 | |
| Cash Plus Interventions for Prevention of Acute Malnutrition in Children Under 5 and Their Mothers in Somalia Cash only, Cash + Social Behavior Change Communication, Cash + top-up cash - Malnutrition, Child, Wasting Disease | Not applicable | Completed | Johns Hopkins Bloomberg School of Public Health | 3384 | 2023-05-17 | 2025-09-08 |
| Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc Adenocarcinoma Pancreas Adenocarcinoma, Cachexia | Recruiting | Wake Forest University Health Sciences | 100 | 2022-06-17 | 2026-07-23 | |
| The Effects of Home-based Physical Activity Telemonitoring Program in Patients With Heart Failure and Muscle Wasting home-based physical activity telemonitoring program - Sarcopenia, Muscular Atrophy | Not applicable | Unknown | Far Eastern Memorial Hospital | 118 | 2022-04-21 | 2022-10-20 |
| Inspiratory Flow Rates Achieved by the COPD Patients Through Breezhaler®, Ellipta® and Handihaler® Inhaler Devices Breezhaler®, Ellipta®, Handihaler® - Pulmonary Disease, Chronic Obstructive (COPD) | Phase 4 | Completed | Novartis Pharmaceuticals | 97 | 2015-12-16 | 2018-06-26 |
| Clinical Study of BYM338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreas BYM338 active drug, Placebo - Cachexia | Phase 2 | Completed | Novartis Pharmaceuticals | 57 | 2011-08-01 | 2016-03-02 |
| Evaluate Weight Gain Using 2 Different Formulations of Megestrol Acetate Oral Suspension for AIDS-related Weight Loss Megestrol acetate oral suspension nanocrystal dispersion 115 mg/mL, Megestrol acetate oral suspension 40 mg/mL - HIV Infections, Cachexia | Phase 2 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 63 | 2004-12-01 | 2017-10-05 |
| Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV Patients Abacavir sulfate, Atazanavir/Ritonavir, Lopinavir/Ritonavir - HIV Infections, Lipodystrophy | Not applicable | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 150 | 2002-03-01 | 2013-07-29 |
| The Effect of Anti-HIV Treatment on Body Characteristics of HIV-Infected Children HIV Infections, HIV Wasting Syndrome | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 100 | 2000-06-01 | 2014-10-29 | |
| A Study to Evaluate High Protein Supplementation in HIV-Positive Patients With Stable Weight Loss Optimune oral nutritional supplement - HIV Infections, HIV Wasting Syndrome | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 56 | 1999-05-01 | 2013-07-29 |
| AIDS Wasting in Women: Anabolic Effects of Testosterone Testosterone - AIDS Wasting Syndrome | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 1998-09-01 | 2010-02-15 | |
| Nutrition Intervention in AIDS Wasting oxandrolone, Progressive Resistance Training - HIV Wasting Syndrome | Phase 4 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 1998-01-01 | 2010-01-13 | |
| Growth Hormone in the Treatment of HIV-Associated Wasting Somatropin; Recombinant human growth hormone (r hGH) - HIV Infections, HIV Wasting Syndrome | Phase 3 | Completed | EMD Serono | 1997-07-01 | 2013-10-22 | |
| A Comparison of Two Caloric Supplements in the Prevention of Weight Loss in Patients With AIDS Who Take Daily Multivitamin and Mineral Supplements Multivitamin and mineral supplements, Peptamen, NuBasics - HIV Infections, HIV Wasting Syndrome | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 536 | 1996-06-01 | 2013-10-01 | |
| Randomized Placebo-Controlled Study of Aerobic Exercise and Resistance Training Plus Megestrol Acetate for HIV-Wasting megestrol, Exercise - Acquired Immunodeficiency Syndrome, HIV Wasting Syndrome | Not applicable | Completed | National Center for Research Resources (NCRR) | 69 | 1995-06-01 | 2005-06-24 |
| A Study to Evaluate the Effect of Nandrolone Decanoate in Women With HIV-Associated Weight Loss Nandrolone decanoate - HIV Infections, HIV Wasting Syndrome | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 38 | 2021-10-29 | |
| A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome Dronabinol, Megestrol acetate - Cachexia, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 56 | 2008-08-25 | |
| A Study of Megestrol Acetate Alone or in Combination With Testosterone Enanthate Drug in the Treatment of HIV-Associated Weight Loss Testosterone enanthate, Megestrol acetate - HIV Infections, HIV Wasting Syndrome | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 80 | 2021-11-01 | |
| A Phase II, Parallel Group, Randomized, Placebo-Controlled Study of the Safety and Efficacy of Thalidomide in Reducing Weight Loss in Adults With HIV Wasting Syndrome Thalidomide - HIV Infections, HIV Wasting Syndrome | Phase 2 | Completed | Celgene Corporation | 75 | 2005-06-24 | |
| Compassionate Use Study of Two Dose Levels of Thalidomide in Adults With HIV Wasting Syndrome Thalidomide - HIV Infections, HIV Wasting Syndrome | Not applicable | Completed | Celgene Corporation | 2005-06-24 |
HIV Wasting Syndrome (14) · HIV Infections (12) · Acquired Immunodeficiency Syndrome (7) · Cachexia (7) · Weight Loss (5) · AIDS-Related Complex (2) · Child Nutrition Disorders (2) · Emaciation (2) · Growth Disorders (2) · Lipodystrophy (2) · Motor Activity (2) · Muscular Atrophy (2) · Pancreatic Neoplasms (2) · Adenocarcinoma (1)
Metabolic Diseases (20) · Nutrition Disorders (20) · Nutritional and Metabolic Diseases (20) · Blood-Borne Infections (14) · Genital Diseases (14) · Immunologic Deficiency Syndromes (14) · Infections (14) · Lentivirus Infections (14) · RNA Virus Infections (14) · Retroviridae Infections (14) · Sexually Transmitted Diseases (14) · Sexually Transmitted Diseases, Viral (14) · Urogenital Diseases (14) · Communicable Diseases (13) · Immune System Diseases (13)
Megestrol Acetate (3) · Thalidomide (2) · CASP8 and FADD-Like Apoptosis Regulating Protein (1) · Dronabinol (1) · Exercise (1) · Geritol (1) · Growth Hormone (1) · Human Growth Hormone (1) · Lopinavir (1) · Megestrol (1) · Nandrolone Decanoate (1) · Nevirapine (1) · Oxandrolone (1) · Peptamen (1) · Testosterone (1)
National Institute of Allergy and Infectious Diseases (NIAID) (7) · Celgene Corporation (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Novartis Pharmaceuticals (2) · EMD Serono (1) · Endo USA Inc., a Keenova Therapeutics Company (1) · Far Eastern Memorial Hospital (1) · Johns Hopkins Bloomberg School of Public Health (1) · National Center for Research Resources (NCRR) (1) · Wake Forest University Health Sciences (1) · World Vision US (1)
United States (15) · Puerto Rico (3) · Argentina (1) · India (1) · Lithuania (1) · Romania (1) · Somalia (1) · South Africa (1) · Switzerland (1) · Taiwan (1) · United Kingdom (1) · Vietnam (1)
Abby Shevitz, MD (1) · Adam Abdulkadir (1) · Bruce R. Bistrian, MD (1) · Caroline Chantry (1) · Charles Opondo, PhD (1) · Egorin M (1) · Elizabeth Svanbert, MD, PhD (1) · Fred R. Sattler, MD (1) · Galetto G (1) · Gilbert CL (1) · Heng-Hsin Tung (1) · Hilary Davies-Kershaw, PhD (1) · J Currier (1) · Jamie Hayden Von Roenn (1) · Jan Fourie, MD (1)
PMID 18519448, PMID 18614924, PMID 19299471, PMID 20345880, PMID 20631646, PMID 29898702, PMID 39007915, PMID 41383165, PMID 41384499, PMID 41717987, PMID 41757817, PMID 42100906