18 completed, 1 active not recruiting, 1 unknown. 20 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 20 | Completed 18, Active not recruiting 1, Unknown 1 |
| Phase 2 | 3 | Completed 3 |
Follow Urethral Diseases: new trials by email Literature Review of Urethral Diseases trials Research Report on Urethral Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Platelet Rich Plasma Versus Mitomycin C Injection Following Visual Internal Urethrotomy in Urethral Stricture Visual internal urethrotomy followed by submucosal intralesional mitomycin C injection, Visual internal urethrotomy followed by submucosal Platlet Rich Plasma injection - Urethral Stricture | Phase 3 | Completed | Ain Shams University | 50 | 2025-08-01 | 2026-10-20 |
| The Effect of Platelet Rich Plasma Injection on Post Internal Urethrotomy Stricture Recurrence PRP injection, VIU - Stricture Urethra | Phase 3 | Completed | Benha University | 156 | 2024-02-19 | 2026-09-23 |
| Laser Visual Internal Urethrotomy With Versus Without Paclitaxel Injection Ho-YAG Laser Visual internal urethrotomy, Ho-YAG Laser Visual internal urethrotomy combined with intralesional submucosal injection of Paclitaxel - Urethral Stricture, Male | Phase 3 | Completed | Ain Shams University | 60 | 2023-05-01 | 2023-11-08 |
| Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study Avelumab, Biospecimen Collection, Bone Scan - Advanced Bladder Urothelial Carcinoma, Advanced Renal Pelvis Urothelial Carcinoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 654 | 2022-06-03 | 2026-10-26 |
| Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty Standard Buccal Harvest, Basic buccal procedure + Long acting local, Basic buccal procedure + Buccal block - Urethral Stricture, Male | Phase 3 | Completed | University of California, San Francisco | 60 | 2022-02-15 | 2026-09-10 |
| Intralesional Injection of Mitomycin C Following Visual Internal Urethrotomy for Recurrent Urethral Stricture Mitomycin c - Urethral Stricture | Phase 2 / Phase 3 | Completed | Ain Shams University | 50 | 2022-01-01 | 2024-01-30 |
| Holmium: YAG Versus Cold Knife Internal Urethrotomy in Management of Short Urethral Strictures visualized internal urethrotomy - Urethral Stricture, Male | Phase 2 / Phase 3 | Completed | Ain Shams University | 80 | 2017-03-01 | 2021-03-02 |
| Four Cycles Versus Six Cycles of Cisplatin-based Chemotherapy in Metastatic Urothelial Carcinoma Treatment duration of cisplatin based chemotherapy - Bladder Cancer, Ureter Cancer | Phase 3 | Unknown | Asan Medical Center | 330 | 2016-09-01 | 2017-09-28 |
| A Study of Ramucirumab (LY3009806) Plus Docetaxel in Participants With Urothelial Cancer Ramucirumab, Docetaxel, Placebo - Urothelial Carcinoma | Phase 3 | Completed | Eli Lilly and Company | 530 | 2015-07-13 | 2023-08-21 |
| Liposomal Bupivacaine To Control Post-Operative Pain Following BMG Liposomal Bupivacaine - Urethral Stricture | Phase 3 | Completed | Urology of Virginia | 50 | 2015-01-20 | 2021-10-01 |
| Phase 3 Evaluation of Re-Injection of NX-1207 for the Treatment of Benign Prostatic Hyperplasia (BPH)(NX02-0022) NX-1207 - Benign Prostatic Hyperplasia, BPH | Phase 3 | Completed | Nymox Corporation | 160 | 2013-04-01 | 2017-03-10 |
| Phase 3 Evaluation of Re-Injection of NX-1207 for the Treatment of Benign Prostatic Hyperplasia (BPH) NX-1207 - Benign Prostatic Hyperplasia | Phase 3 | Completed | Nymox Corporation | 192 | 2011-09-01 | 2014-04-30 |
| Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Bevacizumab, Cisplatin, Gemcitabine Hydrochloride - Advanced Urothelial Carcinoma, Metastatic Bladder Urothelial Carcinoma | Phase 3 | Completed | National Cancer Institute (NCI) | 506 | 2009-07-15 | 2026-06-24 |
| Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Fentanyl sublingual spray, Placebo - Cancer | Phase 3 | Completed | INSYS Therapeutics Inc | 130 | 2007-10-01 | 2014-03-05 |
| Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Azithromycin, Doxycycline - Urethritis | Phase 3 | Completed | University of Washington | 606 | 2007-01-01 | 2018-08-15 |
| Memokath® 044TW Stent for Treatment of Urethral Stricture Memokath stenting - Urethral Stricture | Phase 3 | Completed | Pnn Medical DK | 92 | 2002-12-01 | 2009-11-18 |
| Cisplatin Plus Gemcitabine With or Without Paclitaxel in Treating Patients With Stage IV Urinary Tract Cancer cisplatin, gemcitabine hydrochloride, paclitaxel - Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 608 | 2001-05-01 | 2013-06-12 |
| Combination Chemotherapy in Treating Patients With Transitional Cell Cancer of the Urothelium carboplatin, gemcitabine hydrochloride, methotrexate - Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter | Phase 2 / Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 238 | 2001-01-01 | 2013-06-12 |
| Combination Chemotherapy in Treating Patients With Bladder Cancer carboplatin, cisplatin, doxorubicin hydrochloride - Bladder Cancer, Urethral Cancer | Phase 3 | Completed | Eastern Cooperative Oncology Group | 490 | 1999-04-02 | 2023-06-15 |
| Two-Drug Combination Chemotherapy Compared With Four-Drug Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium carboplatin, cisplatin, doxorubicin hydrochloride - Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter | Phase 3 | Completed | Eastern Cooperative Oncology Group | 330 | 1998-12-03 | 2023-06-22 |
Urethral Neoplasms (9) · Urethral Stricture (8) · Urinary Bladder Neoplasms (8) · Carcinoma, Transitional Cell (3) · Ureteral Neoplasms (3) · Lower Urinary Tract Symptoms (2) · Prostatic Hyperplasia (2) · Prostatic Neoplasms (2) · Urinary Bladder Neck Obstruction (2) · Adrenocortical Carcinoma (1) · Anus Neoplasms (1) · Appendiceal Neoplasms (1) · Astrocytoma (1) · Bile Duct Neoplasms (1) · Blast Crisis (1)
Female Urogenital Diseases (20) · Female Urogenital Diseases and Pregnancy Complications (20) · Male Urogenital Diseases (20) · Urogenital Diseases (20) · Urologic Diseases (20) · Urethral Obstruction (10) · Urinary Bladder Diseases (10) · Neoplasms by Site (9) · Urogenital Neoplasms (9) · Urologic Neoplasms (9) · Neoplasms (8) · Carcinoma (4) · Genital Diseases (4) · Genital Diseases, Male (4)
Cisplatin (4) · Carboplatin (3) · Gemcitabine (3) · Methotrexate (3) · Paclitaxel (3) · Vinblastine (3) · Doxorubicin (2) · fexapotide (2) · 1,2-diaminocyclohexaneplatinum II citrate (1) · Azithromycin (1) · Bevacizumab (1) · Disulfides (1) · Docetaxel (1) · Doxycycline (1) · Fentanyl (1)
Ain Shams University (4) · Eastern Cooperative Oncology Group (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · National Cancer Institute (NCI) (2) · Nymox Corporation (2) · Asan Medical Center (1) · Benha University (1) · Eli Lilly and Company (1) · INSYS Therapeutics Inc (1) · Pnn Medical DK (1) · University of California, San Francisco (1) · University of Washington (1) · Urology of Virginia (1)
United States (13) · Egypt (5) · Belgium (3) · Canada (3) · Denmark (3) · Germany (3) · Hungary (3) · Israel (3) · Italy (3) · Netherlands (3) · Poland (3) · Spain (3) · United Kingdom (3) · Australia (2) · Austria (2)
Bruce J. Roth, MD (2) · Andreas Boehle, MD (1) · Christoph Zielinski, MD (1) · David C. Smith, MD (1) · Gerry Jordan, MD (1) · Gerwin Kaiser, MD (1) · Jae-Lyun Lee, MD., PhD. (1) · Joaquim Bellmunt, MD, PhD (1) · Jonathan E Rosenberg (1) · Jose Baselga, MD (1) · Kurt McCammon, MD FACS (1) · Larry Dillaha, MD (1) · Lindsay Hampson, MD (1) · Lisa E Manhart, PhD (1)
PMID 11001674, PMID 15073851, PMID 1607913, PMID 16330205, PMID 18024869, PMID 18685414, PMID 19786668, PMID 22162575, PMID 22370319, PMID 22480131, PMID 23223595, PMID 24106340, PMID 25616607, PMID 26001531, PMID 27020837, PMID 28916371, PMID 31753727, PMID 32692990, PMID 33160359, PMID 33989025, PMID 34795131, PMID 35388003, PMID 40256659, PMID 40591902
U10CA180821 (2), 2014 (1), R01AI072728 (1), U10CA031946 (1), U19AI031448 (1)