6 unknown, 5 completed, 3 terminated, 2 active not recruiting. 9 Not applicable, 4 Phase 1, 3 Phase 2, 1 Phase 4.
Follow Telomere Shortening: new trials by email Literature Review of Telomere Shortening trials Research Report on Telomere Shortening
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TA-65 and Aging Associated Microvascular Dysfunction TA-65, Placebo - Telomere Shortening, Aging | Not applicable | Not yet recruiting | Medical College of Wisconsin | 180 | 2027-01-01 | 2026-05-01 |
| Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters Combined Training, Nutritional Counseling - Aging, Obesity | Not applicable | Active not recruiting | University of Sao Paulo | 60 | 2026-03-01 | 2026-03-20 |
| Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients (INFRAGEN) Aging, Frailty | Unknown | University Hospital of Ferrara | 340 | 2024-05-20 | 2024-05-28 | |
| Physical Exercise in Patients With Schizophrenia Strength physical exercise programme, Normal life - Schizophrenia, Physical Activity | Not applicable | Unknown | University of Salamanca | 40 | 2024-03-01 | 2024-01-22 |
| Biological and Behavioral Outcomes of Community Nature Walks Reclaiming Nature Intervention - Stress, Psychological, Telomere Shortening | Phase 1 | Unknown | Charlotte Tate | 200 | 2023-02-01 | 2023-09-28 |
| Nasal Brushing for the Diagnosis and Understanding of Telomeropathies Nasal brushing, Sniffin' Sticks - Telomere Disease, Telomere Shortening | Not applicable | Unknown | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 250 | 2022-10-01 | 2022-11-04 |
| The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis Danazol, Placebo - Pulmonary Fibrosis, Telomere Shortening | Phase 2 | Terminated | The University of Queensland | 29 | 2021-09-07 | 2025-08-05 |
| Genetic Evaluation and Modification of Lifestyles to Improve Female Life Expectancy Mediterranean diet, AHA walking program, Mindfulness-based stress reduction - Menopause Syndrome, Inflammation | Not applicable | Terminated | Rush University Medical Center | 5 | 2021-06-22 | 2023-02-13 |
| Study to Evaluate of EXG34217 in Patients With Telomere Biology Disorders With Bone Marrow Failure EXG34217 - Telomere Shortening, Bone Marrow Failure | Phase 1 | Active not recruiting | Elixirgen Therapeutics, Inc. | 12 | 2021-04-08 | 2026-02-06 |
| CBART: The Reduction of Psychological and Physiological Stress in Women Undergoing IVF CBART - Psychological Stress, DNA Degradation, Apoptotic | Not applicable | Completed | University of Haifa | 88 | 2019-04-16 | 2021-09-29 |
| Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy Danazol 200 MG - Telomere Shortening, Telomere Length, Mean Leukocyte | Phase 1 / Phase 2 | Unknown | Assistance Publique - Hôpitaux de Paris | 40 | 2018-10-20 | 2018-10-18 |
| Efficacy of Pythagorean Self-Awareness for Aging Biomarkers Improvement, in T2D Patients and Healthy Individuals. Pythagorean Self-Awareness Intervention(PSAI) - Type 2 Diabetes Mellitus, Telomere Shortening | Not applicable | Completed | National and Kapodistrian University of Athens | 48 | 2018-10-04 | 2021-02-21 |
| Telomere Length in Relation to Acute Stress Response in Critical Care Patients Acute Disease, Telomere Shortening | Completed | Rabin Medical Center | 40 | 2017-10-01 | 2019-06-25 | |
| Lifestyle Change for Better Health Dietary Intervention, Physical Activity Intervention - Bladder Cancer, Telomere Shortening | Not applicable | Terminated | University of Pittsburgh | 8 | 2017-06-01 | 2025-01-10 |
| Stress-Busting Program and QoL, Bio-markers of Immunity/Stress and Cellular Aging SBP English, SBP SPANISH - Stress, Psychological, Telomere Shortening | Not applicable | Completed | The University of Texas Health Science Center at San Antonio | 37 | 2016-09-01 | 2018-10-16 |
| Rosuvastatin Effect on Telomere-telomerase System in ACS rosuvastatin - Telomere Shortening, Telomere Length, Mean Leukocyte | Phase 4 | Unknown | Xiao-dong Zhuang | 400 | 2014-10-01 | 2015-07-14 |
| Nandrolone Decanoate in the Treatment of Telomeropathies Nandrolone Decanoate - Aplastic Anemia, Bone Marrow Failure Syndromes | Phase 1 / Phase 2 | Completed | University of Sao Paulo | 20 | 2014-02-01 | 2023-08-31 |
Inflammation (3) · Motor Activity (3) · Stress, Psychological (3) · Bone Marrow Failure Disorders (2) · Acute Coronary Syndrome (1) · Acute Disease (1) · Aging, Premature (1) · Anemia, Aplastic (1) · Anosmia (1) · Cross Infection (1) · Diabetes Mellitus, Type 2 (1) · Dyskeratosis Congenita (1) · Fractures, Stress (1) · Frailty (1) · Idiopathic Pulmonary Fibrosis (1)
Pathological Conditions, Signs and Symptoms (7) · Behavior (6) · Pathologic Processes (5) · Behavioral Symptoms (3) · Bone Marrow Diseases (3) · Hematologic Diseases (3) · Hemic and Lymphatic Diseases (3) · Signs and Symptoms (3) · Cardiovascular Diseases (2) · Disease Attributes (2) · Lung Diseases (2) · Lung Diseases, Interstitial (2) · Nutritional and Metabolic Diseases (2) · Respiratory Tract Diseases (2) · Anemia (1)
Danazol (2) · Diet Therapy (1) · Diet, Mediterranean (1) · Mindfulness-Based Stress Reduction (1) · Nandrolone Decanoate (1) · Nutrition Assessment (1) · Rosuvastatin Calcium (1)
University of Sao Paulo (2) · Assistance Publique - Hôpitaux de Paris (1) · Charlotte Tate (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Elixirgen Therapeutics, Inc. (1) · Medical College of Wisconsin (1) · National and Kapodistrian University of Athens (1) · Rabin Medical Center (1) · Rush University Medical Center (1) · The University of Queensland (1) · The University of Texas Health Science Center at San Antonio (1) · University Hospital of Ferrara (1) · University of Haifa (1) · University of Pittsburgh (1) · University of Salamanca (1)
United States (5) · Brazil (2) · Israel (2) · Australia (1) · Belgium (1) · Greece (1) · Spain (1)
Ana Beatriz Hortense, MD (1) · Andreas Beyer, Ph.D. (1) · Barbara Soltes, MD (1) · Caroline Huart, MD, PhD (1) · Chih-Ko Yeh, BDS, PhD (1) · Christina Darviri (1) · Dana Bovbjerg, PhD (1) · Ellen C de Freitas, PhD (1) · Iris Harvardi, PhD (1) · John Jakicic, PhD (1) · Julie Cwikel, PhD (1) · Kasiani Myers, MD (1) · Lyda C Arevalo-Flechas, PhD, RN (1)
PMID 34857525, PMID 36579443, PMID 39998303, PMID 40702442
2018 (1), R21CA212628 (1)