4 completed, 2 not yet recruiting, 2 unknown, 1 recruiting. 4 Not applicable, 4 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Unknown 2, Completed 1, Not yet recruiting 1 |
| Phase 4 | 4 | Completed 2, Not yet recruiting 1, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow Synkinesis: new trials by email Literature Review of Synkinesis trials Research Report on Synkinesis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mindfulness in Nonflaccid Facial Paralysis Mindfulness Sessions, No Mindfulness Sessions - Facial Paralysis | Not applicable | Not yet recruiting | Wake Forest University Health Sciences | 24 | 2027-04-01 | 2026-09-30 |
| Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis Botulinum Toxin Type A Injection [Botox] - Synkinesis | Phase 4 | Not yet recruiting | Vanderbilt University Medical Center | 50 | 2026-07-01 | 2026-04-15 |
| Efficacy of Topical Apraclonidine for the Treatment of Ocular Synkinesis Apraclonidine - Synkinesis, Facial Nerve Palsy | Phase 4 | Withdrawn | University of Alabama at Birmingham | 2025-12-01 | 2024-07-19 | |
| Oxymetazoline Drops for Acquired Blepharoptosis From Synkinesis Oxymetazoline 0.1% (Pf) Oph Soln Ud, Preservative free lubricating drops - Blepharoptosis, Synkinesis | Phase 3 | Completed | Milton S. Hershey Medical Center | 36 | 2024-01-11 | 2026-03-09 |
| Functional Recovery From Facial Paralysis Selective muscle electrostimulation with exponential current, Facial muscle reeducation in front of the mirror - Peripheral Facial Paralysis, Facial Palsy | Not applicable | Unknown | Universidad Nacional del Nordeste, Argentina | 50 | 2023-06-01 | 2024-08-01 |
| Neurotomy to Treat Synkinesis Following Peripheral Facial Palsy Botox injection, Neurotomy - Facial Paralysis, Facial Palsy | Not applicable | Unknown | Rebecka Ohm | 73 | 2022-02-01 | 2023-10-06 |
| Kabat Technique and Neuromuscular Effect in Patients With Bell's Palsy Kabat Technique's, Neuromuscular Re-Education - Bell Palsy | Not applicable | Completed | Riphah International University | 24 | 2020-11-15 | 2021-03-19 |
| Mixed Methods Investigation of Chronic Facial Paralysis in Individuals With Synkinesis Neuromuscular Retraining Therapy (4 months), Chemodenervation (4 months), Neuromuscular Retraining + Chemodenervation - Synkinesis | Phase 4 | Completed | University of Wisconsin, Madison | 15 | 2019-10-24 | 2022-09-29 |
| Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis OnabotulinumtoxinA Injectable Product, AbobotulinumtoxinA Injectable Product, Incobotulinumtoxin A Injectable Product - Facial Nerve Injuries, Facial Paresis Associated With Facial Nerve Dysfunction | Phase 4 | Completed | University of Utah | 71 | 2012-07-01 | 2017-07-31 |
| Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome | Recruiting | Boston Children's Hospital | 20000 | 2004-02-01 | 2026-02-11 |
Facial Paralysis (6) · Bell Palsy (4) · Abducens Nerve Diseases (1) · Accessory Nerve Diseases (1) · Athabaskan brainstem dysgenesis (1) · Blepharoptosis (1) · Congenital Cranial Dysinnervation Disorders (1) · Duane Retraction Syndrome (1) · Facial Asymmetry (1) · Facial Nerve Injuries (1) · Facial paresis, hereditary, congenital (1) · Glossopharyngeal Nerve Diseases (1) · Hyperkinesis (1) · Hypoglossal Nerve Diseases (1)
Dyskinesias (10) · Nervous System Diseases (10) · Neurologic Manifestations (10) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (10) · Mouth Diseases (8) · Stomatognathic Diseases (8) · Paralysis (6) · Cranial Nerve Diseases (5) · Facial Nerve Diseases (5) · DNA Virus Infections (4) · Herpesviridae Infections (4) · Infections (4) · Virus Diseases (4) · Eye Diseases (2)
Botulinum Toxins, Type A (4) · incobotulinumtoxinA (2) · Denervation (1) · Nerve Block (1) · Oxymetazoline (1) · abobotulinumtoxinA (1) · apraclonidine (1)
Boston Children's Hospital (1) · Milton S. Hershey Medical Center (1) · Rebecka Ohm (1) · Riphah International University (1) · Universidad Nacional del Nordeste, Argentina (1) · University of Alabama at Birmingham (1) · University of Utah (1) · University of Wisconsin, Madison (1) · Vanderbilt University Medical Center (1) · Wake Forest University Health Sciences (1)
United States (4) · Argentina (1) · Pakistan (1) · Sweden (1)
Benjamin Greene, MD (1) · Birgit Stark, MD, PhD (1) · Dr Aruba Saeed, PHD* (1) · Elizabeth Engle, MD (1) · Jessyka Lighthall, MD (1) · Katherine Gossett, MD (1) · Preston D Ward, MD (1) · Priyesh Patel, MD (1) · Scott R Chaiet, MD (1)