5 terminated. 5 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Terminated 5 |
| Phase 2 | 1 | Terminated 1 |
Follow Subcutaneous Emphysema: new trials by email Literature Review of Subcutaneous Emphysema trials Research Report on Subcutaneous Emphysema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 1/2a, Single- and Multiple-dose Escalation Study of KRRO-110 KRRO-110 - Alpha-1 Anti-trypsin Deficiency, AATD | Phase 1 / Phase 2 | Terminated | Korro Bio, Inc. | 42 | 2025-01-13 | 2026-04-17 |
| A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers and PiXZ Subjects ZF874, Placebo - Alpha1 Anti-Trypsin Deficiency | Phase 1 | Terminated | Z Factor Limited | 69 | 2020-08-03 | 2022-09-19 |
| A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease ALN-AAT, Sterile Normal Saline (0.9% NaCl) - Antitrypsin Deficiency Liver Disease | Phase 1 | Terminated | Alnylam Pharmaceuticals | 26 | 2015-07-09 | 2019-01-07 |
| A Study of ARC-AAT in Healthy Volunteer Subjects and Patients With Alpha-1 Antitrypsin Deficiency (AATD) ARC-AAT Injection, Placebo, Diphenhydramine - Alpha-1 Antitrypsin Deficiency | Phase 1 | Terminated | Arrowhead Pharmaceuticals | 65 | 2015-02-01 | 2026-01-12 |
| A Research Trial of Aralast in New Onset Diabetes (RETAIN) Aralast NP 45 mg dose, Aralast NP 90 mg dose, Aralast NP 180 mg dose - Diabetes Mellitus, Type 1 | Phase 1 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 17 | 2010-10-01 | 2018-06-13 |
alpha 1-Antitrypsin Deficiency (5) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 1 (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Digestive System Diseases (5) · Emphysema (5) · Genetic Diseases, Inborn (5) · Liver Diseases (5) · Lung Diseases (5) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Respiratory Tract Diseases (5) · Autoimmune Diseases (1) · Endocrine System Diseases (1) · Glucose Metabolism Disorders (1) · Immune System Diseases (1) · Metabolic Diseases (1)
Diphenhydramine (1) · alpha 1-Antitrypsin (1)
Alnylam Pharmaceuticals (1) · Arrowhead Pharmaceuticals (1) · Korro Bio, Inc. (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Z Factor Limited (1)
United Kingdom (3) · Australia (2) · Germany (1) · Netherlands (1) · New Zealand (1) · United States (1)
Giuseppe Fiore, MSc MD (1) · Gordon Weir, MD (1) · Malcolm Boyce, BSc MD FRCP FFPM (1) · Patrick Haslett, MD (1)
2015 (1)