108 completed, 45 unknown, 36 recruiting, 34 terminated. 99 Phase 2, 57 Phase 1, 50 Not applicable, 11 Phase 3, 6 Early Phase 1.
Follow Squamous Cell Carcinoma: new trials by email Literature Review of Squamous Cell Carcinoma trials Research Report on Squamous Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chemo-embolization for Head and Neck Cancer Cisplatin - SCCHN, Squamous Cell Carcinoma | Phase 2 | Withdrawn | University of Alabama at Birmingham | 2027-05-01 | 2025-04-27 | |
| A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck Cemiplimab, Fianlimab, Carboplatin - Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | University of Chicago | 90 | 2027-02-07 | 2026-01-20 |
| Phase 1 Study Of TROP2 CAR/IL-15 TGFBR2 KO NK Cell In Patients With Oral Premalignant Lesions TROP2 CAR/IL-15 TGFBR2 KO NK cells - Squamous Cell Carcinoma | Phase 1 | Not yet recruiting | M.D. Anderson Cancer Center | 36 | 2026-12-31 | 2026-06-11 |
| Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell Carcinoma Panitumumab-IRDye800, [18F]NOTA-ABY-030 - HNSCC,Larynx, Pharynx and Oral Cavity, Squamous Cell Carcinoma | Phase 1 | Recruiting | Vanderbilt-Ingram Cancer Center | 30 | 2026-10-01 | 2026-10-19 |
| Impact of Dysport on PMFF Donor Scar Abobotulinumtoxin-A, Control- Saline injection - Skin Cancer Excision Site, Basal Cell Carcinoma | Phase 4 | Not yet recruiting | Vanderbilt University Medical Center | 50 | 2026-09-14 | 2026-08-26 |
| Combining Neo-adjuvant ATR-inhibition With Nodal SBRT for Early-stage Resectable HPV+ OPSCCs ATRN-119, Stereotactic Body Radiation Therapy (SBRT) - HPV Positive Oropharyngeal Squamous Cell Carcinoma, Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Abramson Cancer Center at Penn Medicine | 35 | 2026-08-31 | 2026-07-08 |
| Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION) Active Surveillance With ctHPVDNA (NavDx®) - Squamous Cell Carcinoma, Human Papilloma Virus (HPV) | Phase 2 | Recruiting | Medical University of South Carolina | 36 | 2026-08-12 | 2026-09-14 |
| A Study of IDP-001 in Advanced or Metastatic Solid Tumors IDP-001 - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 / Phase 2 | Recruiting | InduPro, Inc. | 132 | 2026-07-08 | 2026-09-03 |
| Two-photon Fluorescence Microscopy of Dermatologic Biopsies Two photon microscopy imaging - Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma | Not applicable | Recruiting | University of Rochester | 644 | 2026-06-01 | 2026-08-19 |
| Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors Methionine-Reduced Diet - Adenocarcinoma, Basal Cell Carcinoma | Early Phase 1 | Recruiting | University of California, Irvine | 25 | 2026-05-01 | 2026-07-31 |
| AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer | Not yet recruiting | Istituto Italiano di Tecnologia | 283 | 2026-05-01 | 2026-05-19 | |
| Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer Cyclophosphamide and Etoposide in combination, Methotrexate - Squamous Cell Carcinoma, Advanced Head and Neck Cancer | Phase 2 | Not yet recruiting | National Cancer Institute, Egypt | 120 | 2026-04-01 | 2026-04-16 |
| PDT For Induction Therapy For Head And Neck Cancer Toripalimab-tpzi, Cisplatin, Docetaxel - Squamous Cell Carcinoma, Head and Neck Cancer Squamous Cell Carcinoma | Phase 2 | Recruiting | Massachusetts General Hospital | 26 | 2026-03-09 | 2026-10-19 |
| Vitamin D Effects on Immune Microenvironment of Nonmelanoma Skin Cancer After Photodynamic Therapy (PDT) Vitamin D (VitD), Placebo, Photodynamic therapy (PDT) - Nonmelanoma Skin Cancer, Basal Cell Carcinoma | Not applicable | Recruiting | Case Comprehensive Cancer Center | 54 | 2026-02-25 | 2026-08-18 |
| Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN) Toripalimab + Chemotherapy, Toripalimab, Chemoradiotherapy or radiation - Head and Neck Cancer, Squamous Cell Carcinoma | Phase 2 | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 75 | 2026-02-18 | 2026-04-23 |
| Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous SCC for Immunocompromised Patients DaRT seeds - Squamous Cell Carcinoma, Alpha Radiation | Not applicable | Recruiting | Alpha Tau Medical LTD. | 28 | 2026-01-01 | 2026-07-15 |
| The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas Cancer Therapeutic Procedure, Questionnaire Administration - Amyloidosis, Basal Cell Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 27 | 2025-12-18 | 2026-09-30 |
| Oral Mucositis Management in Patients Receiving Radiation for Head and Neck Cancer: An Evaluation of a Barrier Based Treatment Gelclair Oral Mouth Rinse - Squamous Cell Carcinoma, Oropharyngeal Cancers | Phase 4 | Active not recruiting | McMaster University | 29 | 2025-12-15 | 2026-07-13 |
| Patient Preference for Subcutaneous vs. Intravenous Immune Therapy nivolumab, pembrolizumab - Renal Cell Carcinoma, Non Small Cell Lung Cancer | Phase 2 | Recruiting | Diwakar Davar | 880 | 2025-11-04 | 2026-04-16 |
| Drug Screening of Cutaneous Lesions of Squamous Cell Carcinoma Microdevice - Squamous Cell Carcinoma of the Skin, Squamous Cell Carcinoma | Early Phase 1 | Enrolling by invitation | Oliver Jonas | 25 | 2025-10-01 | 2026-05-18 |
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Carcinoma, Squamous Cell (264) · Head and Neck Neoplasms (52) · Carcinoma, Basal Cell (47) · Melanoma (38) · Squamous Cell Carcinoma of Head and Neck (37) · Skin Neoplasms (25) · Carcinoma, Non-Small-Cell Lung (24) · Adenocarcinoma (20) · Neoplasms (20) · Esophageal Neoplasms (19) · Carcinoma (16) · Carcinoma, Renal Cell (14) · Lung Neoplasms (14) · Neoplasm Metastasis (13) · Sarcoma (13)
Neoplasms by Histologic Type (264) · Neoplasms, Glandular and Epithelial (264) · Neoplasms, Squamous Cell (259) · Carcinoma (248) · Neoplasms (244) · Neoplasms by Site (168) · Skin and Connective Tissue Diseases (65) · Skin Diseases (64) · Head and Neck Neoplasms (51) · Respiratory Tract Diseases (47) · Neoplasms, Basal Cell (46) · Digestive System Diseases (42) · Neoplasms, Nerve Tissue (42) · Neuroectodermal Tumors (42) · Neoplasms, Germ Cell and Embryonal (41)
Cisplatin (31) · Radiotherapy (17) · Carboplatin (14) · Docetaxel (14) · Paclitaxel (14) · pembrolizumab (14) · Fluorouracil (11) · Cetuximab (10) · Nivolumab (10) · Radiation (8) · Radiotherapy, Intensity-Modulated (7) · atezolizumab (7) · Cyclophosphamide (6) · Drug Therapy (5) · Leucovorin (5)
Memorial Sloan Kettering Cancer Center (8) · M.D. Anderson Cancer Center (7) · National Cancer Institute (NCI) (7) · H. Lee Moffitt Cancer Center and Research Institute (6) · Mayo Clinic (5) · Abramson Cancer Center at Penn Medicine (4) · Alpha Tau Medical LTD. (4) · Dana-Farber Cancer Institute (4) · Massachusetts General Hospital (4) · Northwestern University (4) · Stanford University (4) · University of Zurich (4) · Amgen (3) · Maastricht University Medical Center (3) · National Taiwan University Hospital (3)
United States (140) · United Kingdom (17) · Canada (14) · France (14) · China (11) · Israel (8) · Italy (8) · Netherlands (8) · Denmark (7) · Taiwan (7) · Belgium (5) · Germany (5) · Spain (5) · Australia (4) · Switzerland (4)
Aron Popovtzer, MD (2) · Christopher Barker, MD (2) · Daniel Eisen, M.D. (2) · Dennis Wigle, MD, PhD (2) · K Mosterd, MD, PhD (2) · Kishwer Nehal, MD (2) · Marshall Posner, MD (2) · Mow-Ming Hsu, MD (2) · Murad Alam, MD (2) · Noga Kurman, MD (2) · Sebastian Zschaeck, MD (2) · Susanne Arnold, MD (2)
PMID 18784101, PMID 19930599, PMID 20231499, PMID 20462662, PMID 21238825, PMID 21339418, PMID 21757257, PMID 22032650, PMID 22750258, PMID 22898037, PMID 22960745, PMID 23384718, PMID 23554766, PMID 23881549, PMID 23945385, PMID 24089446, PMID 24696183, PMID 25596660, PMID 25741400, PMID 25765070, PMID 26562503, PMID 27036206, PMID 27044938, PMID 27152857, PMID 27310809, PMID 27890801, PMID 28596308, PMID 29438373, PMID 29643063, PMID 29698824, PMID 29784451, PMID 29933761, PMID 30017831, PMID 30646153, PMID 30714987, PMID 30940145, PMID 31391011, PMID 31401903, PMID 32002173, PMID 32126267, PMID 32434787, PMID 32479189, PMID 32571298, PMID 32670423, PMID 32673170, PMID 33282388, PMID 33548389, PMID 34385708, PMID 34519839, PMID 34558040
2017 (2), P50DE026787 (2), U10CA180868 (2), 2009 (1), K23DE034496 (1), P01CA021239 (1), P01CA084203 (1), R01CA127971 (1), R37CA258376 (1), R42CA156901 (1), R44CA093106 (1)