4 completed, 4 terminated, 1 recruiting. 9 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 4, Terminated 4, Recruiting 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
Follow Preterm Delivery: new trials by email Literature Review of Preterm Delivery trials Research Report on Preterm Delivery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial 162mg Aspirin, 81mg Aspirin - Preterm Delivery, Obstetrical Complications | Phase 3 | Recruiting | The George Washington University Biostatistics Center | 1800 | 2025-07-01 | 2026-04-09 |
| Correction of Neonatal Glutathione by N-acetylcysteine in Pregnant Women at Risk of Premature Birth (GSH MAP) N-acetylcysteine, Placebo - Preterm Delivery | Phase 2 / Phase 3 | Terminated | Nantes University Hospital | 39 | 2018-11-05 | 2022-12-19 |
| A Randomized Trial of Pessary in Singleton Pregnancies With a Short Cervix Arabin Cervical Pessary - Short Cervix, Preterm Delivery | Phase 3 | Terminated | The George Washington University Biostatistics Center | 544 | 2017-02-14 | 2026-06-23 |
| Efficacy of Oral Progesterone and Vaginal Progesterone After Tocolytic Therapy in Threatened Preterm Labor dydrogesterone, Micronized progesterone - Preterm Delivery | Phase 3 | Completed | Sanpasitthiprasong Hospital | 231 | 2015-08-01 | 2017-10-10 |
| Progesterone (17P, Makena®) for Prolongation of Pregnancy in Women With Preterm Rupture of the Membranes (PROM) 17-alpha-hydroxy-progesterone caproate, Makena®, Castor Oil (Placebo) - Preterm Delivery | Phase 2 / Phase 3 | Completed | Obstetrix Medical Group | 152 | 2011-10-01 | 2018-06-28 |
| Progestagens for the Tertiary Prophylaxis of Preterm Delivery 17 alpha-hydroxy progesterone caproate, micronized Progesterone, Control - Preterm Delivery, Neonatal Complications | Phase 3 | Completed | University of Modena and Reggio Emilia | 254 | 2010-02-01 | 2016-09-23 |
| PREGNANT Short Cervix Trial progesterone, placebo - Preterm Delivery, Short Cervix | Phase 3 | Completed | Juniper Pharmaceuticals, Inc. | 465 | 2008-03-01 | 2012-03-13 |
| RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix 17 alpha-hydroxyprogesterone caproate, Placebo Oil - Preterm Delivery, Cervical Length | Phase 3 | Terminated | The George Washington University Biostatistics Center | 657 | 2007-04-01 | 2019-07-15 |
| Vaginal Progesterone to Prevent Preterm Delivery in Women With Preterm Labor progesterone, placebo - Preterm Delivery, Morbidity | Phase 3 | Terminated | begoña Martinez de Tejada | 384 | 2006-07-01 | 2012-06-06 |
Premature Birth (9) · Obstetric Labor, Premature (2) · Perinatal Death (1) · Stillbirth (1)
Female Urogenital Diseases and Pregnancy Complications (9) · Obstetric Labor Complications (9) · Pregnancy Complications (9) · Urogenital Diseases (9) · Obstetric Labor, Premature (7) · Death (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Fetal Death (1)
Progesterone (5) · Utrogestan (3) · 17 alpha-Hydroxyprogesterone Caproate (2) · 17-alpha-Hydroxyprogesterone (1) · Acetylcysteine (1) · Aspirin (1) · Castor Oil (1) · Dydrogesterone (1)
The George Washington University Biostatistics Center (3) · Juniper Pharmaceuticals, Inc. (1) · Nantes University Hospital (1) · Obstetrix Medical Group (1) · Sanpasitthiprasong Hospital (1) · University of Modena and Reggio Emilia (1) · begoña Martinez de Tejada (1)
United States (5) · Italy (2) · Argentina (1) · Belarus (1) · Chile (1) · Czechia (1) · France (1) · India (1) · Israel (1) · Russia (1) · South Africa (1) · Switzerland (1) · Thailand (1) · Ukraine (1)
Andrew Combs, MD (1) · Begona Martinez de Tejada, MD, PhD (1) · Cande Ananth, PhD, MPH (1) · Fabio Facchinetti, M.D. (1) · George W. Creasy, MD, FACOG (1) · Matthew Hoffman, MD (1) · Matthew K Hoffman, MD, MPH (1) · Menachem Miodovnik, MD (1) · Monica Longo, MD (1) · Piyawadee Wuttikonsammakit, MD (1) · Rebecca Clifton, Ph.D. (1) · Rebecca G Clifton, PhD (1) · Roberto Romero, MD (1) · Sonia Hassan, MD (1)
PMID 21472815, PMID 22206581, PMID 22284156, PMID 23010094, PMID 25209926, PMID 28594783, PMID 37490086, PMID 38576410, PMID 42181103
U24HD036801 (2), 2009 (1), U01HD109332 (1), U10HD021410 (1), U10HD027869 (1), U10HD027915 (1), U10HD027917 (1), U10HD034116 (1), U10HD034136 (1), U10HD034208 (1), U10HD036801 (1), U10HD040485 (1), U10HD040500 (1), U10HD040512 (1), U10HD040544 (1)