40 terminated. 40 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 40 | Terminated 40 |
Follow Neuroectodermal Tumors: new trials by email Literature Review of Neuroectodermal Tumors trials Research Report on Neuroectodermal Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation Definity contrast during ultrasound - Glioma (Any Grade) in the Brain, Glioma | Early Phase 1 | Terminated | University of Colorado, Denver | 2 | 2025-12-05 | 2026-06-22 |
| Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG Temsirolimus - High Grade Glioma, Glioma | Early Phase 1 | Terminated | Nader Sanai | 5 | 2023-05-15 | 2026-05-14 |
| Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial Posaconazole Pill - Glioblastoma, Glioblastoma Multiforme | Early Phase 1 | Terminated | Milton S. Hershey Medical Center | 7 | 2022-05-13 | 2026-01-23 |
| Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas Ketoconazole - Glioblastoma, Glioblastoma Multiforme | Early Phase 1 | Terminated | Milton S. Hershey Medical Center | 1 | 2022-05-11 | 2026-01-07 |
| Natural Progesterone for the Treatment of Recurrent Glioblastoma Quality-of-Life Assessment, Questionnaire Administration, Therapeutic Progesterone - Gliosarcoma, Recurrent Glioblastoma | Early Phase 1 | Terminated | Emory University | 4 | 2022-04-11 | 2026-05-05 |
| Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins. 68Ga-FF58 - Glioblastoma Multiforme, Brain Neoplasms | Early Phase 1 | Terminated | Novartis Pharmaceuticals | 14 | 2021-10-14 | 2025-10-10 |
| Study of Sonodynamic Therapy in Participants With Recurrent High-Grade Glioma SONALA-001(ALA) and MR-Guided Focused Ultrasound device (MRgFUS), MR-Guided Focused Ultrasound device (MRgFUS) - High Grade Glioma | Early Phase 1 | Terminated | Nader Sanai | 10 | 2021-03-15 | 2026-05-14 |
| Feasibility of IV Tc-99m-tilmanocept for Imaging of M2-like TAMs in Metastatic Melanoma Tc-99m tilmanocept - Melanoma | Early Phase 1 | Terminated | John O. Prior | 5 | 2021-02-01 | 2023-12-13 |
| Infigratinib in Recurrent High-Grade Glioma Patients Infigratinib - Glioma, Glioblastoma | Early Phase 1 | Terminated | Nader Sanai | 7 | 2020-07-21 | 2025-10-24 |
| 18F-FluorThanatrace (PET/CT) in Glioblastoma 18F-FluorThanatrace - Glioblastoma | Early Phase 1 | Terminated | University of Pennsylvania | 3 | 2020-02-20 | 2024-06-17 |
| Suicide Plus Immune Gene Therapy for Advanced Melanoma Suicide plus immunogene therapy - Melanoma | Early Phase 1 | Terminated | Hospital Italiano de Buenos Aires | 4 | 2020-02-20 | 2020-02-25 |
| AXL Inhibitor BGB324 in Treating Participants With Recurrent Glioblastoma Undergoing Surgery BGB 324 (before surgery), BGB 324 (after surgery) - Brain and Central Nervous System Tumors | Early Phase 1 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 10 | 2020-01-02 | 2024-02-08 |
| Abemaciclib w/Bevacizumab in Recurrent GBM Pts w/Loss of CDKN2A/B or Gain or Amplification of CDK4/6 Abemaciclib, Bevacizumab - GBM, Glioblastoma | Early Phase 1 | Terminated | University of Texas Southwestern Medical Center | 10 | 2019-12-13 | 2025-08-17 |
| Carvedilol With Chemotherapy in Second Line Glioblastoma and Response of Circulating Tumor Cells Carvedilol - Glioblastoma Multiforme, Glioblastoma | Early Phase 1 | Terminated | West Virginia University | 4 | 2019-07-19 | 2021-09-24 |
| Intratumorally-Administered Topotecan Using Convection-Enhanced Delivery in Patients With Grade III/ IV Glioma Topotecan - Glioma of Brain | Early Phase 1 | Terminated | H. Lee Moffitt Cancer Center and Research Institute | 3 | 2019-06-20 | 2023-05-25 |
| Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases Best Practice, Ketoconazole - Anatomic Stage IV Breast Cancer AJCC v8, Astrocytoma | Early Phase 1 | Terminated | Wake Forest University Health Sciences | 15 | 2019-03-13 | 2026-07-31 |
| MB-CART20.1 Melanoma MB-CART20.1 - Melanoma (Skin) | Early Phase 1 | Terminated | Miltenyi Biomedicine GmbH | 9 | 2019-03-08 | 2024-05-16 |
| Selective Intra-arterial Injection of PRRT in Neuroendocrine Tumor Patients With Liver Metastases [90]Y-DOTATOC - Neuroendocrine Tumors | Early Phase 1 | Terminated | Sandeep Laroia | 3 | 2018-10-11 | 2023-11-28 |
| Oral Immunomodulatory Tyrosine Kinase Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors RXDX-106 - Advanced or Metastatic Solid Tumors | Early Phase 1 | Terminated | Hoffmann-La Roche | 1 | 2018-02-15 | 2019-04-25 |
| A Pilot Study Using Short-Term Cultured Anti-Tumor Autologous Lymphocytes Tumor Infiltrating Lymphocytes, Nivolumab and Ipilimumab - Metastatic Melanoma | Early Phase 1 | Terminated | Yale University | 6 | 2018-02-06 | 2022-07-25 |
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Glioblastoma (14) · Melanoma (11) · Brain Neoplasms (10) · Glioma (9) · Breast Neoplasms (3) · Gliosarcoma (3) · Neoplasms (3) · Astrocytoma (2) · Carcinoma, Non-Small-Cell Lung (2) · Meningioma (2) · Neuroendocrine Tumors (2) · Oligodendroglioma (2) · Uveal Melanoma (2) · Breast Neoplasms, Male (1) · Carcinoma, Hepatocellular (1)
Neoplasms by Histologic Type (40) · Neoplasms, Germ Cell and Embryonal (40) · Neoplasms, Nerve Tissue (40) · Neoplasms (37) · Neoplasms, Glandular and Epithelial (27) · Neoplasms by Site (26) · Neoplasms, Neuroepithelial (25) · Nervous System Diseases (14) · Astrocytoma (13) · Glioma (13) · Nervous System Neoplasms (13) · Neuroendocrine Tumors (13) · Central Nervous System Neoplasms (12) · Nevi and Melanomas (12)
2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (2) · Bevacizumab (2) · Cyclophosphamide (2) · Ipilimumab (2) · Ketoconazole (2) · Magnetic Resonance Spectroscopy (2) · Topotecan (2) · 3-Iodobenzylguanidine (1) · 90Y-octreotide, DOTA-Tyr(3)- (1) · Alemtuzumab (1) · CTLA-4 Antigen (1) · Carboplatin (1) · Carvedilol (1) · Cisplatin (1) · Cryosurgery (1)
Nader Sanai (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · Case Comprehensive Cancer Center (2) · Milton S. Hershey Medical Center (2) · University of Pennsylvania (2) · Cedars-Sinai Medical Center (1) · Children's Hospital Medical Center, Cincinnati (1) · Columbia University (1) · Craig L Slingluff, Jr (1) · Emory University (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Hoffmann-La Roche (1) · Hospital Italiano de Buenos Aires (1) · John O. Prior (1) · M.D. Anderson Cancer Center (1)
United States (34) · Germany (2) · Argentina (1) · France (1) · Sweden (1) · Switzerland (1)
Nader Sanai, MD (2) · Ahmad Tarhini, MD (1) · Alireza Mansouri (1) · Alireza Mansouri, MD (1) · Asgeir S Jakola, MD, PhD (1) · Austin R Pantel, MD (1) · Brad Welling, MD, PhD (1) · Burt Nabors, MD (1) · Chad Quarles (1) · Craig L. Slingluff, Jr., MD (1) · D. Ryan Ormond, MD PhD (1) · Elizabeth Gaughan, MD (1) · Elizabeth Gerstner, MD (1) · Homer A Macapinlac, MD (1) · Hui-Kuo G Shu, MD, PhD, FASTRO (1)
PMID 25179634, PMID 26330458, PMID 26943915, PMID 34667843, PMID 35861778, PMID 37377890, PMID 39386211, PMID 40913745, PMID 41296829, PMID 42494994
P30CA006973 (1), P30CA012197 (1), P30CA068485 (1), P30CA138292 (1), P50CA174521 (1), R01CA178846 (1), R03CA255992 (1), UM1CA137443 (1)