149 suspended. 149 Phase 1, 56 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 149 | Suspended 149 |
| Phase 2 | 56 | Suspended 56 |
Follow Neoplasms: new trials by email Literature Review of Neoplasms trials Research Report on Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial of a Personalized and Adaptive Neoantigen Dose-Adjusted Vaccine Concurrently With Pembrolizumab PANDA-VAC, Pembrolizumab - Squamous Cell Lung Cancer, Squamous Non-small Cell Lung Cancer | Phase 1 | Suspended | UNC Lineberger Comprehensive Cancer Center | 6 | 2027-05-20 | 2026-04-23 |
| Adaptive SBRT Plus Chemoimmunotherapy for ES-SCLC Durvalumab 50 MG/1 ML Intravenous Solution, Etoposide Injection, Cisplatin - Extensive-stage Small-cell Lung Cancer | Phase 1 | Suspended | University of Maryland, Baltimore | 50 | 2027-01-30 | 2026-09-14 |
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma PEP-CMV vaccine, Tetanus booster, Nivolumab - Diffuse Midline Glioma, Diffuse Midline High-grade Glioma | Phase 1 / Phase 2 | Suspended | Washington University School of Medicine | 68 | 2026-11-30 | 2026-10-30 |
| Testing the Combination of Targeted Radiotherapy With Anti-Cancer Drugs, Venetoclax and ASTX-727, to Improve Outcomes for Adults With Newly Diagnosed Acute Myeloid Leukemia Actinium Ac 225 Lintuzumab, Biospecimen Collection, Bone Marrow Aspiration - Acute Myeloid Leukemia | Phase 1 | Suspended | National Cancer Institute (NCI) | 53 | 2026-11-18 | 2026-08-24 |
| Autologous CAR T Cells Targeting GPC3 (RPCAR01) for the Treatment of Advanced or Metastatic GPC3 Expressing Hepatocellular Carcinoma Anti-GPC3-CAR Autologous T Lymphocytes, Biospecimen Collection, Computed Tomography - Advanced Hepatocellular Carcinoma, Metastatic Hepatocellular Carcinoma | Phase 1 | Suspended | Roswell Park Cancer Institute | 24 | 2026-11-15 | 2026-09-15 |
| Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer Montanide (Registered Trademark) ISA-51 VG Adjuvant, H1299 Cell Lysates, N-803 - Non-Small Cell Lung Cancer, Non-Small Cell Lung Carcinoma | Phase 1 / Phase 2 | Suspended | National Cancer Institute (NCI) | 30 | 2026-11-05 | 2026-11-02 |
| Combination Therapy (Mirdametinib and Sirolimus) for RAS Mutated Relapsed Refractory Multiple Myeloma Mirdametinib, Sirolimus - Multiple Myeloma, Relapsed and/or Refractory Multiple Myeloma (RRMM) | Phase 1 / Phase 2 | Suspended | National Cancer Institute (NCI) | 54 | 2026-11-05 | 2026-11-02 |
| Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC) azacytidine, carboplatin, paclitaxel - Non-small Cell Lung Cancer (NSCLC), Carcinoma, Non-Small Cell Lung | Phase 1 / Phase 2 | Suspended | National Cancer Institute (NCI) | 60 | 2026-11-05 | 2026-11-02 |
| TROP2 CAREngineered Cord Blood-Derived NK Cells + Belzutifan In Pancreatic Cancer TGFBR2 KO CAR27/IL-15 NK cells - Pancreatic Cancer | Phase 1 / Phase 2 | Suspended | M.D. Anderson Cancer Center | 37 | 2026-05-26 | 2026-07-31 |
| Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard Treatment of Glioblastoma/Diffuse Midline Glioma and Response to Treatment (Regardless of Mutation Status) S-Gboxin - Glioblastoma Multiforme, Diffuse Midline Glioma, H3 K27M-Mutant | Phase 1 | Suspended | Petrov, Andrey | 10 | 2026-05-20 | 2026-06-03 |
| Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization Autologous total tumor mRNA loaded DOTAP liposome vaccine - Melanoma, Soft Tissue Sarcoma | Phase 1 | Suspended | University of Florida | 18 | 2026-03-17 | 2026-09-17 |
| CRISPR Delivered Anti-BCMA Car-T Therapy for Relapsed or Refractory Multiple Myeloma Leukapheresis, Cyclophosphamide, Chimeric Antigen Receptor T cells (CAR-T) Targeting BCMA - Multiple Myeloma, Recurrent Multiple Myeloma | Phase 1 | Suspended | Thomas Martin, MD | 30 | 2026-02-28 | 2026-06-11 |
| Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue Sarcoma Zanzalintinib, Ipilimumab, Nivolumab - Metastatic Soft-tissue Sarcoma | Phase 1 | Suspended | Washington University School of Medicine | 18 | 2026-01-05 | 2026-09-04 |
| ST-067 in Combination With CD19-Directed CAR T-Cell Therapy (Liso-cel) in Relapsed/Refractory Large B-Cell Lymphoma Vevoctadekin, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified | Phase 1 / Phase 2 | Suspended | Fred Hutchinson Cancer Center | 33 | 2025-12-27 | 2026-09-11 |
| Safety and Efficacy of DIT309 in Advanced Bone and Soft Tissue Sarcomas DIT309 cell injection - Osteosarcoma, Soft Tissue Sarcoma | Phase 1 | Suspended | Tcelltech Inc. | 15 | 2025-11-06 | 2026-10-14 |
| A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL) Cyclophosphamide, Fludarabine, Autologous CCR4 CAR T cells - Relapsed and/or Refractory Mature T Cell Malignancy, Peripheral T-Cell Lymphoma | Phase 1 | Suspended | National Cancer Institute (NCI) | 60 | 2025-09-29 | 2026-10-16 |
| CD70-Targeted CAR-T Therapy in CD70-Positive Advanced Solid Tumors CD70-targeted CAR-T cells - Renal Cell Carcinoma (RCC), Lung Cancer | Phase 1 | Suspended | Chongqing Precision Biotech Co., Ltd | 90 | 2025-09-12 | 2026-09-11 |
| Stereotactic Centralized Ablative Radiotherapy for Locally Advanced Pancreatic Cancer: A Single-Arm Phase I Safety and Feasibility Study SCART Dose Escalation Arm - Pancreatic Cancer, Locally Advanced Pancreatic Cancer | Phase 1 | Suspended | Shandong Cancer Hospital and Institute | 24 | 2025-09-10 | 2026-05-01 |
| 68Ga-Dotatate PET and MRI Guided Radiation Dose Escalation for High Risk Meningioma ⁶⁸Ga-Dotatate PET and MRI Guided Radiation Therapy, Magnetic Resonance Imaging (MRI), 68Ga-Dotatate PET Imaging - High Risk Meningioma, Recurrent Meningioma | Phase 1 | Suspended | Thomas Jefferson University | 24 | 2025-09-05 | 2026-01-23 |
Showing 20 of 149. Sign in to see all of them.
Leukemia, Myeloid, Acute (16) · Pancreatic Neoplasms (13) · Breast Neoplasms (10) · Lung Neoplasms (10) · Melanoma (10) · Myelodysplastic Syndromes (9) · Carcinoma, Non-Small-Cell Lung (8) · Carcinoma, Renal Cell (8) · Colorectal Neoplasms (8) · Multiple Myeloma (8) · Neoplasm Metastasis (8) · Ovarian Neoplasms (8) · Prostatic Neoplasms (7) · Glioma (6)
Neoplasms by Histologic Type (90) · Neoplasms by Site (84) · Hemic and Lymphatic Diseases (46) · Neoplasms, Glandular and Epithelial (36) · Hematologic Diseases (35) · Digestive System Diseases (33) · Digestive System Neoplasms (32) · Immune System Diseases (28) · Immunoproliferative Disorders (28) · Lymphoproliferative Disorders (28) · Urogenital Diseases (23) · Leukemia (22) · Lymphatic Diseases (22) · Neoplasms, Germ Cell and Embryonal (22)
Specimen Handling (18) · Magnetic Resonance Spectroscopy (16) · Biopsy (13) · Cyclophosphamide (11) · Nivolumab (8) · fludarabine (8) · pembrolizumab (7) · Gemcitabine (6) · venetoclax (6) · Bevacizumab (5) · Carboplatin (5) · Leukapheresis (5) · Paclitaxel (5) · Azacitidine (4) · X-Rays (4)
National Cancer Institute (NCI) (13) · City of Hope Medical Center (11) · M.D. Anderson Cancer Center (6) · Northwell Health (3) · University of Chicago (3) · Washington University School of Medicine (3) · Fox Chase Cancer Center (2) · Fred Hutchinson Cancer Center (2) · H. Lee Moffitt Cancer Center and Research Institute (2) · Hokkaido Gastrointestinal Cancer Study Group (2) · Huda Salman (2) · Piramal Enterprises Limited (2) · Roger Williams Medical Center (2) · Roswell Park Cancer Institute (2) · Stanford University (2)
United States (118) · China (18) · Japan (4) · Spain (4) · Canada (3) · Australia (2) · France (2) · Germany (2) · Israel (2) · Italy (2) · Singapore (2) · Switzerland (2) · United Kingdom (2) · Austria (1) · Belgium (1)
John Boockvar, MD (3) · David S Schrump, M.D. (2) · Masahiro Asaka, MD, PhD (2) · Richard P Junghans, PhD, MD (2) · Aby Buchbinder, MD (1) · Adam L Green (1) · Adil Daud, MD (1) · Alan Jeppsen, MD (1) · Alan S. Wayne, MD (1) · Alexandre V. Hirayama, MD (1) · Amandeep Salhotra (1) · Andrei H Iagaru, MD (1) · Andrew Poklepovic, MD (1) · Anna Bar (1) · Annie P Im (1)
PMID 24258465, PMID 27736729, PMID 28054442, PMID 33329935, PMID 34482636, PMID 35129069, PMID 35537408, PMID 36113242, PMID 36356599, PMID 36765881, PMID 38022532, PMID 38497709, PMID 39897044, PMID 40020161, PMID 40706069, PMID 41117344
P30CA033572 (7), P30CA093373 (2), UM1CA186689 (2), UM1CA186690 (2), 2019 (1), P30CA014089 (1), P30CA014599 (1), P30CA060553 (1), R01CA225913 (1), R01CA246553 (1), R01CA296813 (1), U10CA180886 (1), U24CA224309 (1), UM1CA154967 (1), UM1CA186691 (1)